Gene description for SETD5
Gene name SET domain containing 5
Gene symbol SETD5
Other names/aliases -
Species Homo sapiens
 Database cross references - SETD5
ExoCarta ExoCarta_55209
Vesiclepedia VP_55209
Entrez Gene 55209
HGNC 25566
MIM 615743
UniProt Q9C0A6  
 SETD5 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SETD5
Molecular Function
    transcription corepressor activity GO:0003714 IEA
    protein binding GO:0005515 IPI
    methylated histone binding GO:0035064 IBA
    histone H3K9 methyltransferase activity GO:0046974 ISS
    histone H3K36 methyltransferase activity GO:0046975 ISS
    histone H3K9me2 methyltransferase activity GO:0140947 IEA
    histone H3K9 monomethyltransferase activity GO:0140948 IEA
    histone H3K36 trimethyltransferase activity GO:0140955 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of DNA-templated transcription GO:0006355 IBA
    negative regulation of transcription by RNA polymerase III GO:0016480 IEA
    methylation GO:0032259 IEA
    regulation of DNA-templated transcription elongation GO:0032784 ISS
    cognition GO:0050890 ISS
    regulation of synapse assembly GO:0051963 ISS
    regulation of chromatin organization GO:1902275 ISS
Subcellular Localization
    chromatin GO:0000785 ISS
    euchromatin GO:0000791 ISS
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    Set3 complex GO:0034967 IBA
    Rpd3L-Expanded complex GO:0070210 IBA
 Experiment description of studies that identified SETD5 in sEVs
1
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SETD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FTL 2512
Affinity Capture-MS Homo sapiens
2 NAGK 55577
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TP53BP2  
Two-hybrid Homo sapiens
4 SPAG16  
Affinity Capture-MS Homo sapiens
5 TRAF2 7186
Two-hybrid Homo sapiens
6 PRR20A  
Affinity Capture-MS Homo sapiens
7 MEX3A  
Affinity Capture-RNA Homo sapiens
8 RMND5B  
Affinity Capture-MS Homo sapiens
9 DDX58 23586
Affinity Capture-RNA Homo sapiens
10 NXF1 10482
Affinity Capture-RNA Homo sapiens
11 DPPA2  
Two-hybrid Homo sapiens
12 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 VRK1 7443
Affinity Capture-MS Homo sapiens
14 PLEKHG4  
Two-hybrid Homo sapiens
15 PRR20E  
Affinity Capture-MS Homo sapiens
16 CEP70  
Two-hybrid Homo sapiens
17 RPL7A 6130
Cross-Linking-MS (XL-MS) Homo sapiens
18 CCDC85B  
Two-hybrid Homo sapiens
19 KRT40  
Two-hybrid Homo sapiens
20 SORBS3 10174
Two-hybrid Homo sapiens
21 PRMT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FBLN5 10516
Affinity Capture-MS Homo sapiens
23 CALCOCO2  
Two-hybrid Homo sapiens
24 SSRP1 6749
Affinity Capture-MS Homo sapiens
25 MTUS2 23281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 BRD3 8019
Affinity Capture-MS Homo sapiens
27 PIPSL 266971
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SETD5 is involved
No pathways found





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