Gene description for POLR3C
Gene name polymerase (RNA) III (DNA directed) polypeptide C (62kD)
Gene symbol POLR3C
Other names/aliases RPC3
RPC62
Species Homo sapiens
 Database cross references - POLR3C
ExoCarta ExoCarta_10623
Vesiclepedia VP_10623
Entrez Gene 10623
HGNC 30076
UniProt Q9BUI4  
 POLR3C identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for POLR3C
Molecular Function
    single-stranded DNA binding GO:0003697 IDA
    DNA-directed 5'-3' RNA polymerase activity GO:0003899 TAS
    protein binding GO:0005515 IPI
Biological Process
    DNA-templated transcription GO:0006351 IEA
    regulation of transcription by RNA polymerase III GO:0006359 TAS
    positive regulation of interferon-beta production GO:0032728 IMP
    innate immune response GO:0045087 IEA
    positive regulation of innate immune response GO:0045089 IMP
    defense response to virus GO:0051607 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    RNA polymerase III complex GO:0005666 IBA
    RNA polymerase III complex GO:0005666 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified POLR3C in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POLR3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF3C4 9329
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 RSL1D1 26156
Co-fractionation Homo sapiens
3 ROPN1  
Two-hybrid Homo sapiens
4 RBBP8NL  
Two-hybrid Homo sapiens
5 DISC1 27185
Two-hybrid Homo sapiens
6 ENKD1  
Two-hybrid Homo sapiens
7 LOC101060521 101060521
Co-fractionation Homo sapiens
8 CEP63  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 RIT1 6016
Negative Genetic Homo sapiens
10 TRMT1L 81627
Affinity Capture-MS Homo sapiens
11 POLR2H 5437
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
12 POLR2F  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TRAF2 7186
Two-hybrid Homo sapiens
14 KPNA1 3836
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
15 ROCK1 6093
Two-hybrid Homo sapiens
16 COIL  
Two-hybrid Homo sapiens
17 KIAA0408  
Two-hybrid Homo sapiens
18 HAUS1  
Two-hybrid Homo sapiens
19 POLR3A 11128
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
20 L3HYPDH 112849
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MAF1  
Affinity Capture-MS Homo sapiens
22 POLR2K  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 GOLGA2 2801
Two-hybrid Homo sapiens
24 NCKIPSD 51517
Two-hybrid Homo sapiens
25 CD2BP2 10421
Co-fractionation Homo sapiens
26 POLR1C 9533
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
27 POLR2E 5434
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 POLR3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
29 INCA1  
Two-hybrid Homo sapiens
30 WIZ 58525
Co-fractionation Homo sapiens
31 APP 351
Reconstituted Complex Homo sapiens
32 GADD45B  
Affinity Capture-MS Homo sapiens
33 SUCLG1 8802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
35 KPNA2 3838
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 POLR3K  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
37 BRD3 8019
Affinity Capture-MS Homo sapiens
38 VRTN  
Two-hybrid Homo sapiens
39 POLR2L 5441
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
40 NUP50 10762
Proximity Label-MS Homo sapiens
41 KPNA3 3839
Two-hybrid Homo sapiens
42 POLR3E 55718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
43 SMARCA4 6597
Co-fractionation Homo sapiens
44 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
45 CEP44  
Two-hybrid Homo sapiens
46 PNMA5 114824
Two-hybrid Homo sapiens
47 TNR  
Two-hybrid Homo sapiens
48 CBX3 11335
Proximity Label-MS Homo sapiens
49 SNRNP40 9410
Co-fractionation Homo sapiens
50 CRCP  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
51 POLR3F  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
52 POU6F2  
Two-hybrid Homo sapiens
53 GTF3C3 9330
Affinity Capture-Western Homo sapiens
54 PRDM16 63976
Two-hybrid Homo sapiens
55 UBXN1 51035
Two-hybrid Homo sapiens
56 RPA3 6119
Proximity Label-MS Homo sapiens
57 VCP 7415
Affinity Capture-MS Homo sapiens
58 OGT 8473
Reconstituted Complex Homo sapiens
59 POLR3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
60 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
61 NOC4L 79050
Co-fractionation Homo sapiens
62 KRT75 9119
Two-hybrid Homo sapiens
63 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 GTF3C2  
Affinity Capture-Western Homo sapiens
65 POLR3B 55703
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
66 POLR1A  
Co-fractionation Homo sapiens
67 POLR3G  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
68 EP300 2033
Affinity Capture-MS Homo sapiens
69 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
70 TBP  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
71 KATNBL1  
Two-hybrid Homo sapiens
72 POLR1D 51082
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
73 SUB1 10923
Co-fractionation Homo sapiens
74 VAX1  
Two-hybrid Homo sapiens
75 ANKRD23 200539
Two-hybrid Homo sapiens
76 KPNA5 3841
Two-hybrid Homo sapiens
77 GTF3C1  
Affinity Capture-Western Homo sapiens
78 POLR3GL  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 EFEMP1 2202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 KRAS 3845
Negative Genetic Homo sapiens
81 RANGAP1 5905
Co-fractionation Homo sapiens
82 GTF3C5 9328
Affinity Capture-Western Homo sapiens
83 KLHL2 11275
Two-hybrid Homo sapiens
View the network image/svg+xml



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