Gene description for SARM1
Gene name sterile alpha and TIR motif containing 1
Gene symbol SARM1
Other names/aliases MyD88-5
SAMD2
SARM
Species Homo sapiens
 Database cross references - SARM1
ExoCarta ExoCarta_23098
Vesiclepedia VP_23098
Entrez Gene 23098
HGNC 17074
MIM 607732
UniProt Q6SZW1  
 SARM1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SARM1
Molecular Function
    NAD+ nucleosidase activity GO:0003953 IDA
    protein binding GO:0005515 IPI
    signaling adaptor activity GO:0035591 IEA
    identical protein binding GO:0042802 IPI
    NADP+ nucleosidase activity GO:0050135 IEA
    NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 IDA
Biological Process
    signal transduction GO:0007165 IEA
    nervous system development GO:0007399 IEA
    response to glucose GO:0009749 IEA
    NAD catabolic process GO:0019677 IDA
    cell differentiation GO:0030154 IEA
    negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 IEA
    regulation of neuron apoptotic process GO:0043523 IEA
    innate immune response GO:0045087 IEA
    response to axon injury GO:0048678 IDA
    regulation of dendrite morphogenesis GO:0048814 ISS
    nervous system process GO:0050877 IEA
    protein localization to mitochondrion GO:0070585 ISS
    modification of postsynaptic structure GO:0099010 IEA
    regulation of synapse pruning GO:1905806 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IEA
    cytosol GO:0005829 TAS
    microtubule GO:0005874 ISS
    cell surface GO:0009986 IEA
    axon GO:0030424 IEA
    dendrite GO:0030425 IBA
    dendrite GO:0030425 ISS
    neuromuscular junction GO:0031594 IEA
    protein-containing complex GO:0032991 IEA
    synapse GO:0045202 ISS
    glutamatergic synapse GO:0098978 IEA
    extrinsic component of synaptic membrane GO:0099243 IEA
 Experiment description of studies that identified SARM1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SARM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDIPT 10423
Affinity Capture-MS Homo sapiens
2 TICAM2  
PCA Homo sapiens
3 GYPA  
Affinity Capture-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 TRAF6 7189
Affinity Capture-Western Homo sapiens
6 TRAF2 7186
Affinity Capture-Western Homo sapiens
7 STT3A 3703
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
8 CLGN 1047
Affinity Capture-MS Homo sapiens
9 PINK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 NPTN 27020
Affinity Capture-MS Homo sapiens
13 MTCH2 23788
Proximity Label-MS Homo sapiens
14 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SHISA3  
Affinity Capture-MS Homo sapiens
16 IRAK1  
Affinity Capture-MS Homo sapiens
17 CELA2A  
Affinity Capture-MS Homo sapiens
18 GHITM 27069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
19 NLRX1 79671
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
20 OCIAD1 54940
Proximity Label-MS Homo sapiens
21 IRAK2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
22 KDSR 2531
Affinity Capture-MS Homo sapiens
23 C1orf87  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MKRN2 23609
Affinity Capture-RNA Homo sapiens
25 C9orf41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NTRK1 4914
Affinity Capture-MS Homo sapiens
27 ZG16B 124220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MYD88 4615
PCA Homo sapiens
29 HYOU1 10525
Affinity Capture-MS Homo sapiens
30 RNF2  
Affinity Capture-MS Homo sapiens
31 POC1B 282809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SEMA4C 54910
Affinity Capture-MS Homo sapiens
33 RPA3 6119
Proximity Label-MS Homo sapiens
34 RHOT2 89941
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 AKAP1 8165
Proximity Label-MS Homo sapiens
36 TOMM20 9804
Affinity Capture-Western Homo sapiens
37 TACSTD2 4070
Affinity Capture-MS Homo sapiens
38 NFXL1 152518
Affinity Capture-MS Homo sapiens
39 CCDC47 57003
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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