Gene description for TRAF1
Gene name TNF receptor-associated factor 1
Gene symbol TRAF1
Other names/aliases EBI6
MGC:10353
Species Homo sapiens
 Database cross references - TRAF1
ExoCarta ExoCarta_7185
Vesiclepedia VP_7185
Entrez Gene 7185
HGNC 12031
MIM 601711
UniProt Q13077  
 TRAF1 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Thymus 23844026    
 Gene ontology annotations for TRAF1
Molecular Function
    tumor necrosis factor receptor binding GO:0005164 IBA
    tumor necrosis factor receptor binding GO:0005164 IPI
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    thioesterase binding GO:0031996 IPI
    signaling adaptor activity GO:0035591 IBA
    identical protein binding GO:0042802 IPI
Biological Process
    apoptotic process GO:0006915 IEA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IBA
    regulation of canonical NF-kappaB signal transduction GO:0043122 IBA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    protein-containing complex assembly GO:0065003 TAS
    regulation of extrinsic apoptotic signaling pathway GO:2001236 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    plasma membrane signaling receptor complex GO:0098802 IBA
 Experiment description of studies that identified TRAF1 in exosomes
1
Experiment ID 259
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRAF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAIP  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 MORN3  
Two-hybrid Homo sapiens
3 TNFAIP3 7128
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 POM121L4P  
Two-hybrid Homo sapiens
5 SKP1 6500
Affinity Capture-MS Homo sapiens
6 DCAF7 10238
Affinity Capture-MS Homo sapiens
7 C14orf105  
Two-hybrid Homo sapiens
8 SPG21 51324
Two-hybrid Homo sapiens
9 HOXD12  
Two-hybrid Homo sapiens
10 TNIP1 10318
Affinity Capture-Western Homo sapiens
11 TRPV6  
Two-hybrid Homo sapiens
12 LOC149950  
Two-hybrid Homo sapiens
13 SORL1 6653
Affinity Capture-MS Homo sapiens
14 PEX13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CCDC116  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 AES 166
Two-hybrid Homo sapiens
17 SQSTM1 8878
Affinity Capture-MS Homo sapiens
18 GIT2 9815
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
19 ADRB2  
Affinity Capture-MS Homo sapiens
20 GATA2  
Two-hybrid Homo sapiens
21 APC  
Affinity Capture-MS Homo sapiens
22 GMCL1P1  
Two-hybrid Homo sapiens
23 NUPL1 9818
Two-hybrid Homo sapiens
24 TNFRSF8 943
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ECH1 1891
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
26 RBM41  
Two-hybrid Homo sapiens
27 SLC25A48  
Two-hybrid Homo sapiens
28 KPNA2 3838
Two-hybrid Homo sapiens
29 ZNF697  
Two-hybrid Homo sapiens
30 RIPK1 8737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
31 PBX3  
Two-hybrid Homo sapiens
32 ZNF662  
Two-hybrid Homo sapiens
33 RTP5  
Two-hybrid Homo sapiens
34 RB1CC1 9821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 UBC 7316
Affinity Capture-MS Homo sapiens
36 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 AKAP17A  
Two-hybrid Homo sapiens
39 DMRT3  
Two-hybrid Homo sapiens
40 ZNF440  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 UBE2O 63893
Affinity Capture-Western Homo sapiens
42 CASP3 836
Co-localization Homo sapiens
43 GOLGA3 2802
Affinity Capture-MS Homo sapiens
44 RASAL2 9462
Two-hybrid Homo sapiens
45 Tnfrsf12a  
Two-hybrid Mus musculus
46 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 FBXO28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ZNF512B  
Two-hybrid Homo sapiens
49 ZMYND11 10771
Affinity Capture-Western Homo sapiens
50 EWSR1 2130
Two-hybrid Homo sapiens
51 TNFRSF12A 51330
Reconstituted Complex Homo sapiens
52 RASSF5 83593
Two-hybrid Homo sapiens
53 ZNF20  
Two-hybrid Homo sapiens
54 BIRC3 330
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 HMG20B  
Two-hybrid Homo sapiens
56 RIPK2  
Affinity Capture-Western Homo sapiens
57 MAVS 57506
Affinity Capture-Western Homo sapiens
58 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PKNOX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 HTRA2 27429
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 PRDM7  
Two-hybrid Homo sapiens
62 USP7 7874
Reconstituted Complex Homo sapiens
63 TNFRSF1B  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 CFLAR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
65 GFI1B  
Two-hybrid Homo sapiens
66 TNFRSF4  
Affinity Capture-Western Homo sapiens
67 C1orf216  
Two-hybrid Homo sapiens
68 LTBR 4055
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 LCOR 84458
Two-hybrid Homo sapiens
70 KIAA1217 56243
Two-hybrid Homo sapiens
71 AQP1 358
Two-hybrid Homo sapiens
72 SYCE1  
Two-hybrid Homo sapiens
73 PBX1 5087
Affinity Capture-MS Homo sapiens
74 BEX2  
Two-hybrid Homo sapiens
75 ZNF124  
Two-hybrid Homo sapiens
76 UXT 8409
Affinity Capture-MS Homo sapiens
77 CDKN1A  
Two-hybrid Homo sapiens
78 MOS 4342
Two-hybrid Homo sapiens
79 TNFRSF14  
Reconstituted Complex Homo sapiens
80 CHCHD3 54927
Two-hybrid Homo sapiens
81 TRIM42  
Two-hybrid Homo sapiens
82 SCNM1  
Two-hybrid Homo sapiens
83 HEY2  
Two-hybrid Homo sapiens
84 TNFRSF17  
Affinity Capture-Western Homo sapiens
85 DIABLO 56616
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 OSBPL3 26031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 NFATC2IP  
Affinity Capture-Western Homo sapiens
88 SRSF4 6429
Affinity Capture-MS Homo sapiens
89 GEM  
Two-hybrid Homo sapiens
90 C5orf30  
Two-hybrid Homo sapiens
91 BARD1 580
Two-hybrid Homo sapiens
92 DGCR6  
Two-hybrid Homo sapiens
93 HIVEP3 59269
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
94 GORASP2 26003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
95 FAM86C1  
Two-hybrid Homo sapiens
96 SUMO2 6613
Reconstituted Complex Homo sapiens
97 PKN1 5585
Biochemical Activity Homo sapiens
98 PHF21A  
Two-hybrid Homo sapiens
99 BCL6  
Two-hybrid Homo sapiens
100 ZNF581  
Two-hybrid Homo sapiens
101 POP5  
Two-hybrid Homo sapiens
102 DOK3 79930
Two-hybrid Homo sapiens
103 GNG5 2787
Two-hybrid Homo sapiens
104 ARSJ  
Two-hybrid Homo sapiens
105 TEAD4  
Two-hybrid Homo sapiens
106 NGFR 4804
Affinity Capture-Western Homo sapiens
107 C19orf66  
Two-hybrid Homo sapiens
108 BIRC2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 CD40 958
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
110 TBC1D16  
Two-hybrid Homo sapiens
111 STK3 6788
Two-hybrid Homo sapiens
112 CRYGA 1418
Two-hybrid Homo sapiens
113 COX5B 1329
Two-hybrid Homo sapiens
114 ZNF572  
Two-hybrid Homo sapiens
115 EIF2AK3  
Affinity Capture-MS Homo sapiens
116 SIK3 23387
Two-hybrid Homo sapiens
117 TCL1A  
Two-hybrid Homo sapiens
118 CASP6 839
Biochemical Activity Homo sapiens
119 ABHD17A 81926
Two-hybrid Homo sapiens
120 TRADD 8717
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
121 CDCA3 83461
Two-hybrid Homo sapiens
122 LMP1 3783750
Affinity Capture-Western
Reconstituted Complex
123 CCDC120  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
124 ZNF564  
Two-hybrid Homo sapiens
125 ZFYVE21  
Two-hybrid Homo sapiens
126 KLHL38  
Two-hybrid Homo sapiens
127 NEBL 10529
Two-hybrid Homo sapiens
128 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
129 TRAF6 7189
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 TFAP4 7023
Two-hybrid Homo sapiens
131 PDE4D  
Two-hybrid Homo sapiens
132 TUBB4B 10383
Affinity Capture-MS Homo sapiens
133 EPHX1 2052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 ZNF250  
Two-hybrid Homo sapiens
135 TNFRSF18  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
136 ACTN3 89
Two-hybrid Homo sapiens
137 TSSC4  
Two-hybrid Homo sapiens
138 HOXA1 3198
Two-hybrid Homo sapiens
139 KIF1A 547
Two-hybrid Homo sapiens
140 TRAF3 7187
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
141 FOSL2  
Two-hybrid Homo sapiens
142 OSBPL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 Hoxa1  
Two-hybrid Mus musculus
144 CD27  
Affinity Capture-Western Homo sapiens
145 PBX2  
Affinity Capture-MS Homo sapiens
146 TNFRSF13C  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
147 ZMYM6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 EDA2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 CYB5R2 51700
Two-hybrid Homo sapiens
150 CDKN2B 1030
Two-hybrid Homo sapiens
151 A1CF  
Two-hybrid Homo sapiens
152 RELT  
Affinity Capture-Western Homo sapiens
153 ARNT2  
Two-hybrid Homo sapiens
154 CASP10  
Biochemical Activity Homo sapiens
155 GATAD2B 57459
Two-hybrid Homo sapiens
156 HSP90AA2P 3324
Affinity Capture-MS Homo sapiens
157 CD40LG 959
Affinity Capture-Western Homo sapiens
158 RBM45  
Two-hybrid Homo sapiens
159 MYEF2 50804
Two-hybrid Homo sapiens
160 ZNF587  
Two-hybrid Homo sapiens
161 CARHSP1 23589
Two-hybrid Homo sapiens
162 FBF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
163 ZC2HC1C  
Two-hybrid Homo sapiens
164 CHUK 1147
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
165 PSMB1 5689
Two-hybrid Homo sapiens
166 WAC  
Two-hybrid Homo sapiens
167 ALS2CR11  
Two-hybrid Homo sapiens
168 TICAM1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
169 ZNF417  
Two-hybrid Homo sapiens
170 MAP3K14  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
171 TANK 10010
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
172 SPOP  
Reconstituted Complex Homo sapiens
173 DEPTOR 64798
Two-hybrid Homo sapiens
174 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 SLC25A6 293
Two-hybrid Homo sapiens
176 Tnfrsf1b  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
177 HAUS1  
Two-hybrid Homo sapiens
178 OLIG3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
179 TMC8 147138
Affinity Capture-Western Homo sapiens
180 CCDC146  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
181 PIN1 5300
Two-hybrid Homo sapiens
182 RNF31 55072
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
183 EHHADH 1962
Two-hybrid Homo sapiens
184 NUFIP2 57532
Two-hybrid Homo sapiens
185 CCHCR1  
Two-hybrid Homo sapiens
186 IKBKG 8517
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
187 ECI2 10455
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 CASP8 841
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
189 SNX29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 MAPRE2 10982
Two-hybrid Homo sapiens
191 KANSL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 LATS1  
Two-hybrid Homo sapiens
193 PSMA1 5682
Two-hybrid Homo sapiens
194 THAP7  
Two-hybrid Homo sapiens
195 PIGA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 TBK1 29110
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
198 TNFRSF11A  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
199 TRIM37  
Reconstituted Complex Homo sapiens
200 OTUD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
201 PPP1R13B  
Two-hybrid Homo sapiens
202 QRICH1