Gene description for SNX5
Gene name sorting nexin 5
Gene symbol SNX5
Other names/aliases -
Species Homo sapiens
 Database cross references - SNX5
ExoCarta ExoCarta_27131
Entrez Gene 27131
HGNC 14969
MIM 605937
UniProt Q9Y5X3  
 SNX5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SNX5
Molecular Function
    dynactin binding GO:0034452 IDA
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 ISS
Biological Process
    pinocytosis GO:0006907 IDA
    intracellular protein transport GO:0006886 IEA
    retrograde transport, endosome to Golgi GO:0042147 IMP
    vesicle organization GO:0016050 IBA
Subcellular Localization
    ruffle GO:0001726 IEA
    phagocytic cup GO:0001891 IEA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    early endosome membrane GO:0031901 IDA
    endosome GO:0005768 IBA
    macropinocytic cup GO:0070685 IDA
    retromer complex GO:0030904 IDA
    extrinsic component of endosome membrane GO:0031313 IDA
    tubular endosome GO:0097422 IDA
 Experiment description of studies that identified SNX5 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNX5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FANCA  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 CLTC 1213
Two-hybrid Homo sapiens
3 CLTCL1 8218
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 ITSN1 6453
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SNX5 is involved
PathwayEvidenceSource
Golgi Associated Vesicle Biogenesis TAS Reactome





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