Gene description for IFNGR1
Gene name interferon gamma receptor 1
Gene symbol IFNGR1
Other names/aliases CD119
IFNGR
IMD27A
IMD27B
Species Homo sapiens
 Database cross references - IFNGR1
ExoCarta ExoCarta_3459
Entrez Gene 3459
HGNC 5439
MIM 107470
UniProt P15260  
 IFNGR1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for IFNGR1
Molecular Function
    cytokine binding GO:0019955 IEA
    interferon-gamma receptor activity GO:0004906 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    signal transduction GO:0007165 TAS
    response to virus GO:0009615 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
Subcellular Localization
    postsynaptic density GO:0014069 IEA
    plasma membrane GO:0005886 TAS
    vesicle GO:0031982 IEA
    dendrite GO:0030425 IEA
    endoplasmic reticulum GO:0005783 IEA
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified IFNGR1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IFNGR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFNGR2  
Invivo Homo sapiens
2 JAK1 3716
Invivo Homo sapiens
3 IFNG 3458
Co-crystal Structure Homo sapiens
4 IFNGR1 3459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IFNGR1 is involved
PathwayEvidenceSource
Interferon gamma signaling TAS Reactome
Regulation of IFNG signaling TAS Reactome





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