Gene description for ARL6IP5
Gene name ADP-ribosylation factor-like 6 interacting protein 5
Gene symbol ARL6IP5
Other names/aliases DERP11
GTRAP3-18
HSPC127
JWA
PRAF3
addicsin
hp22
jmx
Species Homo sapiens
 Database cross references - ARL6IP5
ExoCarta ExoCarta_10550
Vesiclepedia VP_10550
Entrez Gene 10550
HGNC 16937
MIM 605709
UniProt O75915  
 ARL6IP5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocytes 26054723    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for ARL6IP5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of L-glutamate import across plasma membrane GO:0002037 ISS
    glutathione metabolic process GO:0006749 IEA
    learning or memory GO:0007611 IEA
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IDA
    negative regulation of mitochondrial membrane potential GO:0010917 IMP
    protein transport GO:0015031 IDA
    L-glutamate transmembrane transport GO:0015813 ISS
    positive regulation of stress-activated MAPK cascade GO:0032874 IMP
    cellular response to oxidative stress GO:0034599 IEA
    positive regulation of apoptotic process GO:0043065 IMP
    negative regulation of transport GO:0051051 IBA
    cellular response to organic cyclic compound GO:0071407 IDA
    protein localization to plasma membrane GO:0072659 IEA
    L-glutamate import across plasma membrane GO:0098712 IEA
    positive regulation of cysteine-type endopeptidase activity GO:2001056 IMP
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    presynaptic cytosol GO:0099523 IEA
 Experiment description of studies that identified ARL6IP5 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
11
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
14
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
15
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARL6IP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRRT1  
Affinity Capture-MS Homo sapiens
2 TM4SF5  
Affinity Capture-MS Homo sapiens
3 COPG2 26958
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C5AR1  
Affinity Capture-MS Homo sapiens
7 UBL4A 8266
Affinity Capture-MS Homo sapiens
8 DERL2 51009
Affinity Capture-MS Homo sapiens
9 RPS3A 6189
Cross-Linking-MS (XL-MS) Homo sapiens
10 MARCKS 4082
Proximity Label-MS Homo sapiens
11 LAMP3  
Proximity Label-MS Homo sapiens
12 ARPC2 10109
Affinity Capture-MS Homo sapiens
13 S1PR2 9294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 YWHAE 7531
Affinity Capture-MS Homo sapiens
16 SPEN 23013
Cross-Linking-MS (XL-MS) Homo sapiens
17 USP9X 8239
Co-fractionation Homo sapiens
18 HSD17B11 51170
Proximity Label-MS Homo sapiens
19 DNAJC25 548645
Proximity Label-MS Homo sapiens
20 PTPN1 5770
Proximity Label-MS Homo sapiens
21 ARL6IP1 23204
Affinity Capture-MS Homo sapiens
22 RTN4 57142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SLC22A9  
Affinity Capture-MS Homo sapiens
24 KIAA1429 25962
Affinity Capture-MS Homo sapiens
25 XRCC1 7515
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 RPL10A 4736
Cross-Linking-MS (XL-MS) Homo sapiens
27 MGST1 4257
Co-fractionation Homo sapiens
28 B3GAT1  
Proximity Label-MS Homo sapiens
29 HTR3E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 YWHAZ 7534
Affinity Capture-MS Homo sapiens
31 CCR2  
Two-hybrid Homo sapiens
32 VKORC1 79001
Two-hybrid Homo sapiens
33 SLC6A5  
Affinity Capture-MS Homo sapiens
34 MOG  
Affinity Capture-MS Homo sapiens
35 EVI2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 YWHAG 7532
Affinity Capture-MS Homo sapiens
37 SSR1 6745
Proximity Label-MS Homo sapiens
38 C10orf35  
Affinity Capture-MS Homo sapiens
39 RTN1 6252
Affinity Capture-MS Homo sapiens
40 ATP2A3 489
Affinity Capture-MS Homo sapiens
41 HSD17B2 3294
Affinity Capture-MS Homo sapiens
42 YWHAH 7533
Affinity Capture-MS Homo sapiens
43 DDX6 1656
Affinity Capture-MS Homo sapiens
44 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
45 CLN8 2055
Two-hybrid Homo sapiens
46 SLC6A15 55117
Affinity Capture-MS Homo sapiens
47 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 YWHAB 7529
Affinity Capture-MS Homo sapiens
49 KIAA1715 80856
Proximity Label-MS Homo sapiens
50 ARPC1B 10095
Affinity Capture-MS Homo sapiens
51 KCNK1  
Affinity Capture-MS Homo sapiens
52 HTR3C  
Affinity Capture-MS Homo sapiens
53 LMNB1 4001
Proximity Label-MS Homo sapiens
54 PLSCR1 5359
Affinity Capture-MS Homo sapiens
55 EMD 2010
Proximity Label-MS Homo sapiens
56 IFITM3 10410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 COPE 11316
Affinity Capture-MS Homo sapiens
58 RPL5 6125
Co-fractionation Homo sapiens
59 TSPAN2 10100
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 TMEM43 79188
Affinity Capture-MS Homo sapiens
61 ARL6 84100
Two-hybrid Homo sapiens
62 SARAF  
Affinity Capture-MS Homo sapiens
63 NPDC1  
Affinity Capture-MS Homo sapiens
64 NOC4L 79050
Co-fractionation Homo sapiens
65 YWHAQ 10971
Affinity Capture-MS Homo sapiens
66 RPN1 6184
Proximity Label-MS Homo sapiens
67 ATP4A 495
Affinity Capture-MS Homo sapiens
68 UPK1A 11045
Affinity Capture-MS Homo sapiens
69 TECTB  
Affinity Capture-MS Homo sapiens
70 ELOVL5 60481
Proximity Label-MS Homo sapiens
71 GPR173  
Affinity Capture-MS Homo sapiens
72 SEC61B 10952
Proximity Label-MS Homo sapiens
73 TMEM185A  
Affinity Capture-MS Homo sapiens
74 REEP5 7905
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 BCAP31 10134
Proximity Label-MS Homo sapiens
76 C4orf32  
Affinity Capture-MS Homo sapiens
77 EFNA4  
Affinity Capture-MS Homo sapiens
78 HADHB 3032
Co-fractionation Homo sapiens
79 SLC25A12 8604
Proximity Label-MS Homo sapiens
80 RPN2 6185
Proximity Label-MS Homo sapiens
81 ICAM2 3384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 LRRC59 55379
Proximity Label-MS Homo sapiens
83 SDHA 6389
Affinity Capture-MS Homo sapiens
84 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
85 LMNB2 84823
Affinity Capture-MS Homo sapiens
86 TMEM128  
Affinity Capture-MS Homo sapiens
87 HSD3B7 80270
Proximity Label-MS Homo sapiens
88 CYB5R3 1727
Co-fractionation Homo sapiens
89 ARF6 382
Proximity Label-MS Homo sapiens
90 ATP1B3 483
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 LPAR1 1902
Affinity Capture-MS Homo sapiens
92 HIST1H2BO 8348
Affinity Capture-MS Homo sapiens
93 DMAP1 55929
Affinity Capture-MS Homo sapiens
94 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
96 RPA3 6119
Proximity Label-MS Homo sapiens
97 ATP2A1 487
Proximity Label-MS Homo sapiens
98 CMTM5  
Affinity Capture-MS Homo sapiens
99 ZDHHC22  
Affinity Capture-MS Homo sapiens
100 ACKR2  
Affinity Capture-MS Homo sapiens
101 TSPAN11 441631
Affinity Capture-MS Homo sapiens
102 PARP4 143
Co-fractionation Homo sapiens
103 RNF185  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
104 LMNA 4000
Proximity Label-MS Homo sapiens
105 P2RY12 64805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ARPC1A 10552
Affinity Capture-MS Homo sapiens
107 TMEM170A  
Affinity Capture-MS Homo sapiens
108 CLPP 8192
Proximity Label-MS Homo sapiens
109 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
110 COPZ1 22818
Affinity Capture-MS Homo sapiens
111 VDAC3 7419
Co-fractionation Homo sapiens
112 TACR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 TP53 7157
Affinity Capture-MS Homo sapiens
114 PRAF2 11230
Cross-Linking-MS (XL-MS) Homo sapiens
115 MAX  
Co-fractionation Homo sapiens
116 RTN3 10313
Affinity Capture-MS Homo sapiens
117 ATL2 64225
Affinity Capture-MS Homo sapiens
118 TSPAN15 23555
Affinity Capture-MS Homo sapiens
119 NUP35 129401
Proximity Label-MS Homo sapiens
120 ERGIC1 57222
Proximity Label-MS Homo sapiens
121 ACTR2 10097
Affinity Capture-MS Homo sapiens
122 SLC25A4 291
Co-fractionation Homo sapiens
123 SEC62 7095
Proximity Label-MS Homo sapiens
124 GP5 2814
Affinity Capture-MS Homo sapiens
125 RAB7A 7879
Proximity Label-MS Homo sapiens
126 S1PR4  
Affinity Capture-MS Homo sapiens
127 LPAR2 9170
Affinity Capture-MS Homo sapiens
128 DNAJC1 64215
Proximity Label-MS Homo sapiens
129 VIPR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 RAB5C 5878
Proximity Label-MS Homo sapiens
131 CNR2  
Affinity Capture-MS Homo sapiens
132 CKAP4 10970
Proximity Label-MS Homo sapiens
133 SLC1A1 6505
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
134 ESYT1 23344
Affinity Capture-MS Homo sapiens
135 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 CCDC47 57003
Affinity Capture-MS Homo sapiens
137 DERL1 79139
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here