Gene description for NOC3L
Gene name nucleolar complex associated 3 homolog (S. cerevisiae)
Gene symbol NOC3L
Other names/aliases AD24
C10orf117
FAD24
Species Homo sapiens
 Database cross references - NOC3L
ExoCarta ExoCarta_64318
Vesiclepedia VP_64318
Entrez Gene 64318
HGNC 24034
MIM 610769
UniProt Q8WTT2  
 NOC3L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for NOC3L
Molecular Function
    chromatin binding GO:0003682 IBA
    RNA binding GO:0003723 HDA
Biological Process
    DNA replication initiation GO:0006270 IBA
    fat cell differentiation GO:0045444 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 IDA
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified NOC3L in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NOC3L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL11 6135
Affinity Capture-MS Homo sapiens
2 CDC14B 8555
Proximity Label-MS Homo sapiens
3 ZNF668  
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 RPL26L1 51121
Affinity Capture-MS Homo sapiens
6 NOP58 51602
Co-fractionation Homo sapiens
7 ZNF346  
Affinity Capture-MS Homo sapiens
8 SRPK2 6733
Affinity Capture-MS Homo sapiens
9 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
10 LHX2  
Proximity Label-MS Homo sapiens
11 RPL13A 23521
Affinity Capture-MS Homo sapiens
12 RPL37A 6168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NOP56 10528
Proximity Label-MS Homo sapiens
14 RPS19 6223
Affinity Capture-MS Homo sapiens
15 RPL10 6134
Affinity Capture-MS Homo sapiens
16 KIF20A 10112
Affinity Capture-MS Homo sapiens
17 RPL14 9045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PNMAL1  
Affinity Capture-MS Homo sapiens
19 SOX2  
Proximity Label-MS Homo sapiens
20 PTPRB 5787
Affinity Capture-MS Homo sapiens
21 FAU 2197
Affinity Capture-MS Homo sapiens
22 CENPA  
Proximity Label-MS Homo sapiens
23 DNAJB6 10049
Proximity Label-MS Homo sapiens
24 APEX1 328
Proximity Label-MS Homo sapiens
25 DDX23 9416
Proximity Label-MS Homo sapiens
26 GPATCH4 54865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 RPL10A 4736
Affinity Capture-MS Homo sapiens
28 ETV3  
Proximity Label-MS Homo sapiens
29 PRR11  
Affinity Capture-MS Homo sapiens
30 KIF23 9493
Affinity Capture-MS Homo sapiens
31 DDX24 57062
Co-fractionation Homo sapiens
32 USP39 10713
Affinity Capture-MS Homo sapiens
33 CCDC137  
Affinity Capture-MS Homo sapiens
34 RRP12 23223
Co-fractionation Homo sapiens
35 PRC1 9055
Affinity Capture-MS Homo sapiens
36 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ANOS1 3730
Affinity Capture-MS Homo sapiens
38 WDR12 55759
Co-fractionation Homo sapiens
39 POLR1E  
Proximity Label-MS Homo sapiens
40 ZNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SRP14 6727
Affinity Capture-MS Homo sapiens
42 ADARB1 104
Affinity Capture-MS Homo sapiens
43 TNFRSF1B  
Affinity Capture-MS Homo sapiens
44 RRP8  
Affinity Capture-MS Homo sapiens
45 FBL 2091
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
46 H2AFY2 55506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 KLF16  
Affinity Capture-MS Homo sapiens
48 MYCN  
Affinity Capture-MS Homo sapiens
49 RPL4 6124
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
50 MAK16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RPL19 6143
Affinity Capture-MS Homo sapiens
52 DYNLT1 6993
Proximity Label-MS Homo sapiens
53 PES1 23481
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
54 LIN28A  
Affinity Capture-MS Homo sapiens
55 BRIX1 55299
Co-fractionation Homo sapiens
56 FSCN1 6624
Affinity Capture-MS Homo sapiens
57 CHMP4C 92421
Affinity Capture-MS Homo sapiens
58 EIF2AK2 5610
Affinity Capture-MS Homo sapiens
59 PNO1 56902
Co-fractionation Homo sapiens
60 DDX21 9188
Affinity Capture-MS Homo sapiens
61 PLEKHO1 51177
Affinity Capture-MS Homo sapiens
62 TARBP2  
Affinity Capture-MS Homo sapiens
63 RBM4B  
Affinity Capture-MS Homo sapiens
64 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
65 SRSF6 6431
Affinity Capture-MS Homo sapiens
66 NOP2 4839
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
67 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
68 RPL18A 6142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PRKRA 8575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 NTRK1 4914
Affinity Capture-MS Homo sapiens
71 RPL31 6160
Proximity Label-MS Homo sapiens
72 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
74 REXO4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 NACA 4666
Cross-Linking-MS (XL-MS) Homo sapiens
76 DICER1  
Affinity Capture-MS Homo sapiens
77 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
78 LYAR 55646
Affinity Capture-MS Homo sapiens
79 RPL36 25873
Affinity Capture-MS Homo sapiens
80 HECTD1 25831
Affinity Capture-MS Homo sapiens
81 RPLP0 6175
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
82 SRPK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 MAGEB2 4113
Affinity Capture-MS Homo sapiens
84 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
85 FGF13  
Affinity Capture-MS Homo sapiens
86 CD3EAP  
Proximity Label-MS Homo sapiens
87 WDR46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 ANLN 54443
Affinity Capture-MS Homo sapiens
89 FGFBP1 9982
Affinity Capture-MS Homo sapiens
90 ZBTB2 57621
Affinity Capture-MS Homo sapiens
91 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 FANCD2  
Affinity Capture-MS Homo sapiens
93 ABT1 29777
Affinity Capture-MS Homo sapiens
94 RPL7A 6130
Affinity Capture-MS Homo sapiens
95 RC3H2  
Affinity Capture-MS Homo sapiens
96 SIRT7  
Affinity Capture-MS Homo sapiens
97 SRSF4 6429
Affinity Capture-MS Homo sapiens
98 ZNF622 90441
Affinity Capture-MS Homo sapiens
99 SRSF1 6426
Affinity Capture-MS Homo sapiens
100 SRSF5 6430
Affinity Capture-MS Homo sapiens
101 NPM3 10360
Affinity Capture-MS Homo sapiens
102 ZNF71  
Affinity Capture-MS Homo sapiens
103 CUL3 8452
Affinity Capture-MS Homo sapiens
104 RPS8 6202
Affinity Capture-MS Homo sapiens
105 WDR55  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 RPL3 6122
Affinity Capture-MS Homo sapiens
107 EBNA1BP2 10969
Co-fractionation Homo sapiens
108 NUP43 348995
Proximity Label-MS Homo sapiens
109 RPL7L1 285855
Affinity Capture-MS Homo sapiens
110 IPO5 3843
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 PDCD11 22984
Affinity Capture-MS Homo sapiens
112 PUS7 54517
Co-fractionation Homo sapiens
113 SOX15  
Affinity Capture-MS Homo sapiens
114 DGKZ  
Affinity Capture-MS Homo sapiens
115 RPA3 6119
Proximity Label-MS Homo sapiens
116 MAGEB10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 DNAJC9 23234
Proximity Label-MS Homo sapiens
118 DLST 1743
Affinity Capture-MS Homo sapiens
119 RNF151  
Affinity Capture-MS Homo sapiens
120 RPL22 6146
Affinity Capture-MS Homo sapiens
121 RPS25 6230
Cross-Linking-MS (XL-MS) Homo sapiens
122 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
123 RPL18 6141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 DDRGK1 65992
Affinity Capture-MS Homo sapiens
125 RNF2  
Affinity Capture-MS Homo sapiens
126 TBCA 6902
Cross-Linking-MS (XL-MS) Homo sapiens
127 H2AFB2  
Affinity Capture-MS Homo sapiens
128 CCDC140  
Affinity Capture-MS Homo sapiens
129 RPL13 6137
Affinity Capture-MS Homo sapiens
130 SURF6  
Affinity Capture-MS Homo sapiens
131 PSMB10 5699
Affinity Capture-MS Homo sapiens
132 ZC3H10  
Affinity Capture-MS Homo sapiens
133 RBM34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 SIRT6  
Affinity Capture-MS Homo sapiens
135 PARP1 142
Proximity Label-MS Homo sapiens
136 HMGN4  
Affinity Capture-MS Homo sapiens
137 PDGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 ILF3 3609
Affinity Capture-MS Homo sapiens
139 TP53 7157
Affinity Capture-MS Homo sapiens
140 RRS1 23212
Affinity Capture-MS Homo sapiens
141 MNDA 4332
Affinity Capture-MS Homo sapiens
142 ZNF746  
Affinity Capture-MS Homo sapiens
143 USP36  
Affinity Capture-MS Homo sapiens
144 MEN1 4221
Affinity Capture-MS Homo sapiens
145 DGCR8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 ZNF48  
Affinity Capture-MS Homo sapiens
147 SRP72 6731
Co-fractionation Homo sapiens
148 COX8A  
Proximity Label-MS Homo sapiens
149 TBL3 10607
Co-fractionation Homo sapiens
150 H2AFB3  
Affinity Capture-MS Homo sapiens
151 DDX58 23586
Affinity Capture-RNA Homo sapiens
152 MKI67  
Affinity Capture-MS Homo sapiens
153 NIFK 84365
Proximity Label-MS Homo sapiens
154 RPL35 11224
Affinity Capture-MS Homo sapiens
155 KRR1 11103
Affinity Capture-MS Homo sapiens
156 NEIL1  
Affinity Capture-MS Homo sapiens
157 NOC2L 26155
Affinity Capture-MS Homo sapiens
158 RPS24 6229
Proximity Label-MS Homo sapiens
159 GLI4  
Affinity Capture-MS Homo sapiens
160 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 RPL8 6132
Affinity Capture-MS Homo sapiens
162 RPL28 6158
Affinity Capture-MS Homo sapiens
163 RPL23A 6147
Affinity Capture-MS Homo sapiens
164 KRAS 3845
Negative Genetic Homo sapiens
165 HNRNPU 3192
Affinity Capture-MS Homo sapiens
166 RC3H1 149041
Affinity Capture-MS Homo sapiens
167 NFE2L3 9603
Cross-Linking-MS (XL-MS) Homo sapiens
168 RPL17 6139
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NOC3L is involved
No pathways found





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