Gene description for DHRS7B
Gene name dehydrogenase/reductase (SDR family) member 7B
Gene symbol DHRS7B
Other names/aliases CGI-93
SDR32C1
Species Homo sapiens
 Database cross references - DHRS7B
ExoCarta ExoCarta_25979
Vesiclepedia VP_25979
Entrez Gene 25979
HGNC 24547
MIM 616160
UniProt Q6IAN0  
 DHRS7B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DHRS7B
Molecular Function
    acylglycerone-phosphate reductase (NADP+) activity GO:0000140 TAS
    transcription corepressor activity GO:0003714 IEA
    DNA-binding transcription factor binding GO:0140297 IEA
Biological Process
    phosphatidylcholine biosynthetic process GO:0006656 IEA
    inflammatory response GO:0006954 IEA
    ether lipid biosynthetic process GO:0008611 TAS
    neutrophil differentiation GO:0030223 IEA
    negative regulation of DNA-templated transcription GO:0045892 IEA
    brown fat cell differentiation GO:0050873 IEA
    adipose tissue development GO:0060612 IEA
    regulation of cold-induced thermogenesis GO:0120161 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    transcription regulator complex GO:0005667 IEA
    peroxisomal membrane GO:0005778 TAS
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
 Experiment description of studies that identified DHRS7B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DHRS7B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 GABRG2  
Cross-Linking-MS (XL-MS) Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 FOXA1  
Affinity Capture-MS Homo sapiens
6 C15orf48  
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 CD70 970
Affinity Capture-MS Homo sapiens
9 NAAA  
Affinity Capture-MS Homo sapiens
10 ATP2A3 489
Affinity Capture-MS Homo sapiens
11 GPR45  
Affinity Capture-MS Homo sapiens
12 GYPB  
Affinity Capture-MS Homo sapiens
13 AIFM1 9131
Affinity Capture-MS Homo sapiens
14 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
15 KIF14 9928
Affinity Capture-MS Homo sapiens
16 TP53BP1 7158
Affinity Capture-MS Homo sapiens
17 KLK5 25818
Affinity Capture-MS Homo sapiens
18 FFAR1  
Affinity Capture-MS Homo sapiens
19 RAB1B 81876
Co-fractionation Homo sapiens
20 LAMP3  
Affinity Capture-MS Homo sapiens
21 MFSD4  
Affinity Capture-MS Homo sapiens
22 GP9 2815
Affinity Capture-MS Homo sapiens
23 LRRC25  
Affinity Capture-MS Homo sapiens
24 KCNK1  
Affinity Capture-MS Homo sapiens
25 TMEM184A  
Affinity Capture-MS Homo sapiens
26 MEN1 4221
Affinity Capture-MS Homo sapiens
27 ITLN1 55600
Affinity Capture-MS Homo sapiens
28 CD274 29126
Affinity Capture-MS Homo sapiens
29 MGARP  
Affinity Capture-MS Homo sapiens
30 PRSS50  
Affinity Capture-MS Homo sapiens
31 COMMD2 51122
Affinity Capture-MS Homo sapiens
32 EHD4 30844
Cross-Linking-MS (XL-MS) Homo sapiens
33 EGFR 1956
Affinity Capture-MS Homo sapiens
34 DPEP1 1800
Affinity Capture-MS Homo sapiens
35 KLRD1  
Affinity Capture-MS Homo sapiens
36 KLRB1  
Affinity Capture-MS Homo sapiens
37 CLPP 8192
Proximity Label-MS Homo sapiens
38 TMEM72  
Affinity Capture-MS Homo sapiens
39 AQP3  
Affinity Capture-MS Homo sapiens
40 RIPK4  
Affinity Capture-MS Homo sapiens
41 SLC22A9  
Affinity Capture-MS Homo sapiens
42 APP 351
Reconstituted Complex Homo sapiens
43 SHANK2 22941
Cross-Linking-MS (XL-MS) Homo sapiens
44 ACIN1 22985
Co-fractionation Homo sapiens
45 VSIG4  
Affinity Capture-MS Homo sapiens
46 ALPI  
Affinity Capture-MS Homo sapiens
47 WWP2 11060
Affinity Capture-MS Homo sapiens
48 OTUD1 220213
Affinity Capture-MS Homo sapiens
49 PARK2  
Affinity Capture-MS Homo sapiens
50 HECW2  
Affinity Capture-MS Homo sapiens
51 COQ9  
Affinity Capture-MS Homo sapiens
52 RAB7A 7879
Co-fractionation Homo sapiens
53 A4GNT  
Affinity Capture-MS Homo sapiens
54 SPRTN  
Affinity Capture-MS Homo sapiens
55 GPR182  
Affinity Capture-MS Homo sapiens
56 BRD1 23774
Affinity Capture-MS Homo sapiens
57 VIPR1  
Affinity Capture-MS Homo sapiens
58 THTPA  
Affinity Capture-MS Homo sapiens
59 CUL3 8452
Affinity Capture-MS Homo sapiens
60 DDRGK1 65992
Affinity Capture-MS Homo sapiens
61 SLC1A1 6505
Affinity Capture-MS Homo sapiens
62 GABRG1  
Cross-Linking-MS (XL-MS) Homo sapiens
63 ARHGAP31 57514
Affinity Capture-MS Homo sapiens
64 RPA3 6119
Proximity Label-MS Homo sapiens
65 BRE 9577
Affinity Capture-MS Homo sapiens
66 C9orf72  
Affinity Capture-MS Homo sapiens
67 GOLT1B 51026
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DHRS7B is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Plasmalogen biosynthesis TAS Reactome
Wax and plasmalogen biosynthesis TAS Reactome





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