Gene description for CHD3
Gene name chromodomain helicase DNA binding protein 3
Gene symbol CHD3
Other names/aliases Mi-2a
Mi2-ALPHA
ZFH
Species Homo sapiens
 Database cross references - CHD3
ExoCarta ExoCarta_1107
Vesiclepedia VP_1107
Entrez Gene 1107
HGNC 1918
MIM 602120
UniProt Q12873  
 CHD3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CHD3
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    DNA binding GO:0003677 IBA
    chromatin binding GO:0003682 IBA
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    helicase activity GO:0004386 NAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    zinc ion binding GO:0008270 NAS
    four-way junction helicase activity GO:0009378 IEA
    ATP hydrolysis activity GO:0016887 IBA
    ATP hydrolysis activity GO:0016887 IDA
    double-stranded DNA helicase activity GO:0036121 IEA
    histone binding GO:0042393 IBA
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent chromatin remodeler activity GO:0140658 IBA
    ATP-dependent chromatin remodeler activity GO:0140658 IDA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 IDA
    chromatin remodeling GO:0006338 IMP
    regulation of DNA-templated transcription GO:0006355 NAS
    spindle organization GO:0007051 IDA
    centrosome cycle GO:0007098 IDA
    DNA duplex unwinding GO:0032508 IEA
    regulation of cell fate specification GO:0042659 NAS
    negative regulation of DNA-templated transcription GO:0045892 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    chromatin looping GO:0140588 IEA
    regulation of stem cell differentiation GO:2000736 NAS
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    NuRD complex GO:0016581 IBA
    NuRD complex GO:0016581 IDA
    NuRD complex GO:0016581 IPI
    NuRD complex GO:0016581 NAS
    PML body GO:0016605 IDA
    centriolar satellite GO:0034451 IDA
 Experiment description of studies that identified CHD3 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CHD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 GATAD2B 57459
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ATPIF1 93974
Two-hybrid Homo sapiens
5 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
6 LGR4 55366
Affinity Capture-MS Homo sapiens
7 SGSM2  
Two-hybrid Homo sapiens
8 KPNA1 3836
Affinity Capture-MS Homo sapiens
9 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
10 ZNF296  
Affinity Capture-MS Homo sapiens
11 AR 367
Proximity Label-MS Homo sapiens
12 MEN1 4221
Affinity Capture-MS Homo sapiens
13 SUZ12  
Affinity Capture-MS Homo sapiens
14 GADD45A  
Two-hybrid Homo sapiens
15 TTR 7276
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
17 PAICS 10606
Two-hybrid Homo sapiens
18 RPL10 6134
Affinity Capture-MS Homo sapiens
19 SMARCA1 6594
Affinity Capture-MS Homo sapiens
20 HIST1H2BB 3018
Affinity Capture-Western Homo sapiens
21 UBC 7316
Reconstituted Complex Homo sapiens
22 THOC7 80145
Two-hybrid Homo sapiens
23 SAP30 8819
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
24 SLC27A6  
Two-hybrid Homo sapiens
25 SUMO1 7341
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
26 SBNO1 55206
Co-fractionation Homo sapiens
27 TAF1  
Affinity Capture-MS Homo sapiens
28 KPNB1 3837
Two-hybrid Homo sapiens
29 SOX2  
Affinity Capture-MS Homo sapiens
30 TRIM54  
Two-hybrid Homo sapiens
31 CENPA  
Proximity Label-MS Homo sapiens
32 HSFY1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SAFB 6294
Two-hybrid Homo sapiens
34 HDAC3 8841
Co-fractionation Homo sapiens
35 TRIM28 10155
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
36 PCNT  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
37 Cdk2ap1  
Affinity Capture-MS Mus musculus
38 CHAF1A  
Affinity Capture-MS Homo sapiens
39 KIF23 9493
Affinity Capture-MS Homo sapiens
40 MCM2 4171
Affinity Capture-MS Homo sapiens
41 SHMT2 6472
Affinity Capture-RNA Homo sapiens
42 CDK2AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ZMYND8 23613
Affinity Capture-MS Homo sapiens
44 PLK4  
Two-hybrid Homo sapiens
45 METAP2 10988
Co-fractionation Homo sapiens
46 PIAS4  
Two-hybrid Homo sapiens
47 MTF2  
Affinity Capture-MS Homo sapiens
48 ARID4B  
Affinity Capture-MS Homo sapiens
49 ZNF460  
Affinity Capture-MS Homo sapiens
50 HSPH1 10808
Two-hybrid Homo sapiens
51 CLIP1 6249
Co-fractionation Homo sapiens
52 CSTF2 1478
Two-hybrid Homo sapiens
53 SIN3B  
Affinity Capture-MS Homo sapiens
54 NR1H2  
Two-hybrid Homo sapiens
55 ADARB1 104
Affinity Capture-MS Homo sapiens
56 RAD51  
Two-hybrid Homo sapiens
57 ZNF512B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 EED  
Affinity Capture-MS Homo sapiens
59 RPL29 6159
Two-hybrid Homo sapiens
60 ZNF219  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 SERF2 10169
Two-hybrid Homo sapiens
62 PHF1  
Affinity Capture-MS Homo sapiens
63 CHD3 1107
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
64 SALL4  
Affinity Capture-MS Homo sapiens
65 SMARCA2 6595
Affinity Capture-Western Homo sapiens
66 MTA2 9219
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
67 BCL11B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 GSK3B 2932
Two-hybrid Homo sapiens
69 LRIF1  
Two-hybrid Homo sapiens
70 MBD3L2  
Affinity Capture-MS Homo sapiens
71 XRCC4  
Two-hybrid Homo sapiens
72 ZHX1  
Two-hybrid Homo sapiens
73 RPL17 6139
Affinity Capture-MS Homo sapiens
74 PHF20L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ZKSCAN8  
Affinity Capture-MS Homo sapiens
76 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
77 SHPRH  
Affinity Capture-MS Homo sapiens
78 RGS2  
Two-hybrid Homo sapiens
79 C17orf49 124944
Affinity Capture-MS Homo sapiens
80 CTBP1 1487
Two-hybrid Homo sapiens
81 SDCCAG3  
Two-hybrid Homo sapiens
82 HIC1  
Affinity Capture-Western Homo sapiens
83 PSME1 5720
Two-hybrid Homo sapiens
84 TEAD1  
Proximity Label-MS Homo sapiens
85 PSMD14 10213
Affinity Capture-MS Homo sapiens
86 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
87 HTT 3064
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
88 SRRT 51593
Two-hybrid Homo sapiens
89 CBX3 11335
Proximity Label-MS Homo sapiens
90 UBE2I 7329
Two-hybrid Homo sapiens
91 KDM1A 23028
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
92 Srp72  
Affinity Capture-MS Mus musculus
93 GIT1 28964
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
94 UBA3 9039
Two-hybrid Homo sapiens
95 FUBP1 8880
Two-hybrid Homo sapiens
96 MAN2A2 4122
Two-hybrid Homo sapiens
97 BARD1 580
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
98 DDX5 1655
Affinity Capture-Western Homo sapiens
99 CASP6 839
Two-hybrid Homo sapiens
100 FAM134A 79137
Two-hybrid Homo sapiens
101 BPTF 2186
Affinity Capture-MS Homo sapiens
102 SUMO2 6613
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
103 MOV10 4343
Affinity Capture-RNA Homo sapiens
104 LUC7L2 51631
Two-hybrid Homo sapiens
105 MBD2 8932
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
106 ENO1 2023
Affinity Capture-RNA Homo sapiens
107 BCL6  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
108 CHD5 26038
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
109 RPL36 25873
Affinity Capture-MS Homo sapiens
110 KDM5B  
Affinity Capture-Western Homo sapiens
111 HECTD1 25831
Affinity Capture-MS Homo sapiens
112 SUDS3  
Affinity Capture-MS Homo sapiens
113 MRPL22  
Affinity Capture-MS Homo sapiens
114 MBD3 53615
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
115 MAGEB2 4113
Affinity Capture-MS Homo sapiens
116 SAT1  
Two-hybrid Homo sapiens
117 KLF12  
Proximity Label-MS Homo sapiens
118 CEBPA  
Proximity Label-MS Homo sapiens
119 FGF13  
Affinity Capture-MS Homo sapiens
120 AIMP2 7965
Two-hybrid Homo sapiens
121 ZBED1  
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
122 GPS2  
Two-hybrid Homo sapiens
123 PHLPP1  
Proximity Label-MS Homo sapiens
124 TWIST1  
Co-localization Homo sapiens
125 PTN  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
126 CBX4  
Biochemical Activity Homo sapiens
127 HABP4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
128 ADH5 128
Two-hybrid Homo sapiens
129 PAX6  
Proximity Label-MS Homo sapiens
130 ZBTB2 57621
Affinity Capture-MS Homo sapiens
131 CPSF1 29894
Co-fractionation Homo sapiens
132 YAE1D1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
133 HIST1H3A 8350
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
134 NR4A1  
Two-hybrid Homo sapiens
135 SMARCC2 6601
Co-fractionation Homo sapiens
136 KIF15 56992
Two-hybrid Homo sapiens
137 SOX6  
Proximity Label-MS Homo sapiens
138 TPR 7175
Co-fractionation Homo sapiens
139 SMARCA5 8467
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
140 RPL13A 23521
Affinity Capture-MS Homo sapiens
141 IKZF3  
Affinity Capture-MS Homo sapiens
142 CD2BP2 10421
Co-fractionation Homo sapiens
143 TAL1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
144 MEX3A  
Affinity Capture-RNA Homo sapiens
145 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
146 RAD51B  
Cross-Linking-MS (XL-MS) Homo sapiens
147 HYPK 25764
Affinity Capture-MS Homo sapiens
148 PRG2  
Two-hybrid Homo sapiens
149 RPL14 9045
Affinity Capture-MS Homo sapiens
150 MX1 4599
Two-hybrid Homo sapiens
151 CTTN 2017
Two-hybrid Homo sapiens
152 BHLHE40  
Two-hybrid Homo sapiens
153 CSNK2A1 1457
Affinity Capture-Western Homo sapiens
154 HSD17B10 3028
Two-hybrid Homo sapiens
155 YY1 7528
Proximity Label-MS Homo sapiens
156 MAFG  
Two-hybrid Homo sapiens
157 IKZF1  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
158 TP73  
Two-hybrid Homo sapiens
159 BRMS1L  
Affinity Capture-MS Homo sapiens
160 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
161 TXNDC9 10190
Two-hybrid Homo sapiens
162 NXF1 10482
Affinity Capture-RNA Homo sapiens
163 JUN 3725
Affinity Capture-Western Homo sapiens
164 HNF4A  
Proximity Label-MS Homo sapiens
165 MYBL2 4605
Affinity Capture-MS Homo sapiens
166 LIN9  
Affinity Capture-MS Homo sapiens
167 PIAS1 8554
Biochemical Activity Homo sapiens
168 ETV5  
Two-hybrid Homo sapiens
169 SERBP1 26135
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
170 VIM 7431
Two-hybrid Homo sapiens
171 PHF6  
Affinity Capture-MS Homo sapiens
172 HJURP  
Affinity Capture-MS Homo sapiens
173 IMMT 10989
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
174 BCL11A 53335
Affinity Capture-MS Homo sapiens
175 PRPF40A 55660
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
176 SOX5 6660
Proximity Label-MS Homo sapiens
177 RNF2  
Affinity Capture-MS Homo sapiens
178 BMI1  
Affinity Capture-MS Homo sapiens
179 HAT1 8520
Affinity Capture-MS Homo sapiens
180 MYB  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
181 TNFRSF14  
Two-hybrid Homo sapiens
182 LIN52  
Affinity Capture-MS Homo sapiens
183 RPS16 6217
Affinity Capture-MS Homo sapiens
184 CCDC8  
Affinity Capture-MS Homo sapiens
185 GATAD1  
Affinity Capture-MS Homo sapiens
186 TNNT1  
Two-hybrid Homo sapiens
187 UROD 7389
Two-hybrid Homo sapiens
188 GATAD2A 54815
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
189 RPL13 6137
Affinity Capture-MS Homo sapiens
190 TAF6 6878
Affinity Capture-Western Homo sapiens
191 SPOP  
Two-hybrid Homo sapiens
192 SIRT6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
193 SKIL  
Two-hybrid Homo sapiens
194 TRPS1  
Affinity Capture-MS Homo sapiens
195 SAP130  
Affinity Capture-MS Homo sapiens
196 TP53 7157
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
197 SIN3A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
198 PHF12  
Affinity Capture-MS Homo sapiens
199 FABP4 2167
Two-hybrid Homo sapiens
200 MTA1 9112
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
201 PCMT1 5110
Two-hybrid Homo sapiens
202 FBP2 8789
Two-hybrid Homo sapiens
203 SAP18 10284
Co-fractionation Homo sapiens
204 DPY30 84661
Affinity Capture-MS Homo sapiens
205 CASP8 841
Two-hybrid Homo sapiens
206 KLF3  
Proximity Label-MS Homo sapiens
207 CHD6 84181
Co-fractionation Homo sapiens
208 TCERG1 10915
Two-hybrid Homo sapiens
209 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
210 CHD4 1108
Affinity Capture-Western