Gene description for MED1
Gene name mediator complex subunit 1
Gene symbol MED1
Other names/aliases CRSP1
CRSP200
DRIP205
DRIP230
PBP
PPARBP
PPARGBP
RB18A
TRAP220
TRIP2
Species Homo sapiens
 Database cross references - MED1
ExoCarta ExoCarta_5469
Vesiclepedia VP_5469
Entrez Gene 5469
HGNC 9234
MIM 604311
UniProt Q15648  
 MED1 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MED1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    transcription coactivator binding GO:0001223 IPI
    chromatin binding GO:0003682 IMP
    transcription coregulator activity GO:0003712 IBA
    transcription coregulator activity GO:0003712 IDA
    transcription coactivator activity GO:0003713 IDA
    transcription coactivator activity GO:0003713 IMP
    transcription corepressor activity GO:0003714 ISS
    protein binding GO:0005515 IPI
    nuclear receptor binding GO:0016922 IDA
    nuclear receptor binding GO:0016922 IPI
    nuclear estrogen receptor binding GO:0030331 IPI
    nuclear receptor coactivator activity GO:0030374 IMP
    nuclear receptor coactivator activity GO:0030374 NAS
    chromatin DNA binding GO:0031490 IEA
    histone acetyltransferase binding GO:0035035 IEA
    nuclear vitamin D receptor binding GO:0042809 IBA
    nuclear vitamin D receptor binding GO:0042809 IPI
    nuclear vitamin D receptor binding GO:0042809 NAS
    nuclear vitamin D receptor binding GO:0042809 TAS
    nuclear retinoic acid receptor binding GO:0042974 IBA
    nuclear retinoic acid receptor binding GO:0042974 IPI
    peroxisome proliferator activated receptor binding GO:0042975 IPI
    protein-containing complex binding GO:0044877 IEA
    nuclear thyroid hormone receptor binding GO:0046966 IBA
    nuclear thyroid hormone receptor binding GO:0046966 IDA
    nuclear thyroid hormone receptor binding GO:0046966 IPI
    LBD domain binding GO:0050693 IPI
    ubiquitin protein ligase activity GO:0061630 IEA
    general transcription initiation factor binding GO:0140296 IEA
    DNA-binding transcription factor binding GO:0140297 IPI
    promoter-specific chromatin binding GO:1990841 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    cell morphogenesis GO:0000902 IMP
    angiogenesis GO:0001525 ISS
    liver development GO:0001889 IEA
    embryonic placenta development GO:0001892 IEA
    lens development in camera-type eye GO:0002088 ISS
    thyroid hormone receptor signaling pathway GO:0002154 IMP
    ventricular trabecula myocardium morphogenesis GO:0003222 IEA
    retinal pigment epithelium development GO:0003406 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    thyroid hormone generation GO:0006590 IEA
    protein import into nucleus GO:0006606 IEA
    androgen biosynthetic process GO:0006702 IMP
    brain development GO:0007420 IEA
    lactation GO:0007595 IEA
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of keratinocyte proliferation GO:0010839 IMP
    protein ubiquitination GO:0016567 IEA
    keratinocyte differentiation GO:0030216 IMP
    monocyte differentiation GO:0030224 IEA
    nuclear receptor-mediated steroid hormone signaling pathway GO:0030518 IDA
    animal organ regeneration GO:0031100 IEA
    positive regulation of transcription elongation by RNA polymerase II GO:0032968 NAS
    positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA
    embryonic heart tube development GO:0035050 IEA
    embryonic hindlimb morphogenesis GO:0035116 IEA
    embryonic hemopoiesis GO:0035162 IEA
    peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA
    cellular response to hepatocyte growth factor stimulus GO:0035729 IEA
    megakaryocyte development GO:0035855 ISS
    mRNA transcription by RNA polymerase II GO:0042789 ISS
    negative regulation of apoptotic process GO:0043066 ISS
    G0 to G1 transition GO:0045023 IEA
    fat cell differentiation GO:0045444 IDA
    positive regulation of keratinocyte differentiation GO:0045618 IMP
    positive regulation of erythrocyte differentiation GO:0045648 IMP
    negative regulation of neuron differentiation GO:0045665 ISS
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    erythrocyte development GO:0048821 ISS
    enucleate erythrocyte development GO:0048822 IEA
    RNA polymerase II preinitiation complex assembly GO:0051123 NAS
    hematopoietic stem cell differentiation GO:0060218 IEA
    positive regulation of transcription initiation by RNA polymerase II GO:0060261 IDA
    positive regulation of transcription initiation by RNA polymerase II GO:0060261 NAS
    positive regulation of type II interferon-mediated signaling pathway GO:0060335 IEA
    mammary gland branching involved in thelarche GO:0060744 IEA
    mammary gland branching involved in pregnancy GO:0060745 IEA
    epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA
    positive regulation of G0 to G1 transition GO:0070318 IEA
    regulation of vitamin D receptor signaling pathway GO:0070562 IEA
    cellular response to epidermal growth factor stimulus GO:0071364 IDA
    cellular response to steroid hormone stimulus GO:0071383 IDA
    cellular response to thyroid hormone stimulus GO:0097067 IBA
    cellular response to thyroid hormone stimulus GO:0097067 IDA
    positive regulation of hepatocyte proliferation GO:2000347 IEA
    regulation of RNA biosynthetic process GO:2001141 IMP
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IEA
    chromatin GO:0000785 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    membrane GO:0016020 HDA
    mediator complex GO:0016592 IBA
    mediator complex GO:0016592 IDA
    mediator complex GO:0016592 IMP
    protein-DNA complex GO:0032993 IEA
    core mediator complex GO:0070847 IPI
 Experiment description of studies that identified MED1 in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MED1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 POLR2G 5436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
4 NCOA6  
Reconstituted Complex Homo sapiens
5 RALY 22913
Co-fractionation Homo sapiens
6 MED17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
7 MED7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TRRAP 8295
Co-purification Homo sapiens
9 RPAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RPA2 6118
Two-hybrid Homo sapiens
11 MED29  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 QKI 9444
Affinity Capture-MS Homo sapiens
13 ACTC1 70
Proximity Label-MS Homo sapiens
14 FBXL19  
Affinity Capture-MS Homo sapiens
15 MED9  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MED13L 23389
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HNRNPC 3183
Co-fractionation Homo sapiens
18 ATM 472
Affinity Capture-Western Homo sapiens
19 SCAF4 57466
Affinity Capture-MS Homo sapiens
20 MED24 9862
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 Med22  
Affinity Capture-MS Mus musculus
22 MED12L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MED13 9969
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 APOA2 336
Affinity Capture-MS Homo sapiens
25 POLR2I 5438
Affinity Capture-MS Homo sapiens
26 FBXW7  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
27 POLL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 Thrb  
Two-hybrid Rattus norvegicus
29 MED27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TFIP11  
Two-hybrid Homo sapiens
31 THRAP3 9967
Co-purification Homo sapiens
32 NR1H2  
Two-hybrid Homo sapiens
33 ZNF326 284695
Co-fractionation Homo sapiens
34 MED22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 BRD4 23476
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
36 ATG16L1 55054
Affinity Capture-MS Homo sapiens
37 POLR2C 5432
Affinity Capture-MS Homo sapiens
38 MECP2 4204
Affinity Capture-MS Homo sapiens
39 POLR2M  
Affinity Capture-MS Homo sapiens
40 VDR  
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
41 POLR2H 5437
Affinity Capture-MS Homo sapiens
42 MED4 29079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CASK 8573
Two-hybrid Homo sapiens
44 MED1 5469
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
45 SPAG5 10615
Affinity Capture-MS Homo sapiens
46 MED20 9477
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
48 CTDP1 9150
Reconstituted Complex Homo sapiens
49 PARK2  
Affinity Capture-MS Homo sapiens
50 SUPT7L  
Affinity Capture-Western Homo sapiens
51 NUP50 10762
Proximity Label-MS Homo sapiens
52 SMEK1 55671
Affinity Capture-MS Homo sapiens
53 CBX3 11335
Proximity Label-MS Homo sapiens
54 Tsnax  
Two-hybrid Mus musculus
55 MED14  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 NTRK1 4914
Affinity Capture-MS Homo sapiens
57 MED26  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 TGS1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
59 SUPT3H  
Affinity Capture-Western Homo sapiens
60 YWHAQ 10971
Reconstituted Complex Homo sapiens
61 MED25  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 GATA2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
63 MED31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ACAD11 84129
Affinity Capture-MS Homo sapiens
65 GJB5  
Two-hybrid Homo sapiens
66 SETD7 80854
Co-fractionation Homo sapiens
67 NR1I3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CCNT1  
Co-fractionation Homo sapiens
69 MED15  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 POLR2B 5431
Affinity Capture-MS Homo sapiens
71 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
72 RBM5  
Two-hybrid Homo sapiens
73 CCNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 EPAS1  
Affinity Capture-MS Homo sapiens
75 PPARG 5468
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
76 AKAP9 10142
Two-hybrid Homo sapiens
77 POLR2E 5434
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 BRD2  
Affinity Capture-MS Homo sapiens
79 SREBF1 6720
Co-purification Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
80 RPRD2  
Affinity Capture-MS Homo sapiens
81 CDK19 23097
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 NR3C1 2908
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
83 GPN1  
Affinity Capture-MS Homo sapiens
84 POLR2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 OBFC1 79991
Affinity Capture-MS Homo sapiens
86 PLK1 5347
Affinity Capture-MS Homo sapiens
87 KIF1A 547
Two-hybrid Homo sapiens
88 POLR2A 5430
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
89 THRA  
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
90 HNF4A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
91 FASN 2194
Positive Genetic Homo sapiens
92 MED10  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 TADA2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
94 MYC  
Reconstituted Complex Homo sapiens
95 RPA3 6119
Proximity Label-MS Homo sapiens
96 EMC2 9694
Affinity Capture-MS Homo sapiens
97 MED23 9439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
99 BRD3 8019
Affinity Capture-MS Homo sapiens
100 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
101 BIRC5  
Affinity Capture-MS Homo sapiens
102 AR 367
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
103 MED11  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 HECTD1 25831
Affinity Capture-MS Homo sapiens
105 MED19  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ESR2  
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
107 RARA 5914
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
108 POLR2F  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
109 SIRT6  
Affinity Capture-MS Homo sapiens
110 PARP1 142
Affinity Capture-Western Homo sapiens
111 KAT2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
114 CDK8 1024
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 POLR2L 5441
Affinity Capture-MS Homo sapiens
116 PIN1 5300
Reconstituted Complex Homo sapiens
117 Pparg 19016
Reconstituted Complex Mus musculus
118 MEN1 4221
Affinity Capture-MS Homo sapiens
119 MED8  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 MED6  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 POU1F1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
122 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
123 ZNF281  
Co-fractionation Homo sapiens
124 ESR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
125 MED30  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 MED16 10025
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 MED18  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
129 TCL1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 Eif3g 53356
Two-hybrid Mus musculus
131 MED12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 EZH2  
Reconstituted Complex Homo sapiens
133 TRIP4 9325
Affinity Capture-MS Homo sapiens
134 RXRA 6256
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
135 CDK9 1025
Affinity Capture-MS Homo sapiens
136 Fez2  
Two-hybrid Mus musculus
137 CIT 11113
Affinity Capture-MS Homo sapiens
138 XRCC6 2547
Proximity Label-MS Homo sapiens
139 ZC3H13 23091
Affinity Capture-MS Homo sapiens
140 GABPA 2551
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
141 PPARGC1A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
142 MED28  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MED1 is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) TAS Reactome
Adipogenesis TAS Reactome
Adipogenesis IEA Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression IEA Reactome
Cellular response to chemical stress TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress IEA Reactome
Cellular responses to stress TAS Reactome
Circadian Clock IEA Reactome
Cytoprotection by HMOX1 TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Heme signaling IEA Reactome
Infectious disease TAS Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of lipids TAS Reactome
Metabolism of lipids IEA Reactome
Metabolism of steroids TAS Reactome
Mitochondrial biogenesis TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Nuclear Receptor transcription pathway TAS Reactome
Organelle biogenesis and maintenance TAS Reactome
PPARA activates gene expression TAS Reactome
PPARA activates gene expression IEA Reactome
Regulation of cholesterol biosynthesis by SREBP (SREBF) TAS Reactome
Regulation of lipid metabolism by PPARalpha TAS Reactome
Regulation of lipid metabolism by PPARalpha IEA Reactome
Respiratory Syncytial Virus Infection Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RORA activates gene expression IEA Reactome
RSV-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Transcriptional activation of mitochondrial biogenesis TAS Reactome
Transcriptional regulation of white adipocyte differentiation TAS Reactome
Transcriptional regulation of white adipocyte differentiation IEA Reactome
Viral Infection Pathways TAS Reactome





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