Gene description for FOXN3
Gene name forkhead box N3
Gene symbol FOXN3
Other names/aliases C14orf116
CHES1
PRO1635
Species Homo sapiens
 Database cross references - FOXN3
ExoCarta ExoCarta_1112
Entrez Gene 1112
HGNC 1928
MIM 602628
UniProt O00409  
 FOXN3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for FOXN3
Molecular Function
    sequence-specific DNA binding GO:0043565 IEA
    protein binding GO:0005515 IPI
    protein C-terminus binding GO:0008022 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
Biological Process
    mitotic G2 DNA damage checkpoint GO:0007095 IGI
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IC
 Experiment description of studies that identified FOXN3 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FOXN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FOXN3 is involved
No pathways found





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