Gene description for ZFP36L2
Gene name ZFP36 ring finger protein-like 2
Gene symbol ZFP36L2
Other names/aliases BRF2
ERF-2
ERF2
RNF162C
TIS11D
Species Homo sapiens
 Database cross references - ZFP36L2
ExoCarta ExoCarta_678
Entrez Gene 678
HGNC 1108
MIM 612053
UniProt P47974  
 ZFP36L2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ZFP36L2
Molecular Function
    metal ion binding GO:0046872 IEA
    mRNA 3'-UTR AU-rich region binding GO:0035925 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
    DNA binding GO:0003677 IEA
    poly(A) RNA binding GO:0044822 IDA
    AU-rich element binding GO:0017091 IDA
Biological Process
    regulation of mRNA stability GO:0043488 IEA
    hemopoiesis GO:0030097 ISS
    negative regulation of stem cell differentiation GO:2000737 ISS
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 ISS
    somatic stem cell maintenance GO:0035019 ISS
    definitive hemopoiesis GO:0060216 ISS
    regulation of transcription, DNA-templated GO:0006355 TAS
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 IEA
    somatic stem cell division GO:0048103 ISS
    cell proliferation GO:0008283 TAS
    T cell differentiation in thymus GO:0033077 IEA
    mRNA catabolic process GO:0006402 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified ZFP36L2 in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ZFP36L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ZFP36L2 is involved
No pathways found





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