Gene description for STAT2
Gene name signal transducer and activator of transcription 2, 113kDa
Gene symbol STAT2
Other names/aliases ISGF-3
P113
STAT113
Species Homo sapiens
 Database cross references - STAT2
ExoCarta ExoCarta_6773
Vesiclepedia VP_6773
Entrez Gene 6773
HGNC 11363
MIM 600556
UniProt P52630  
 STAT2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for STAT2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    ubiquitin-like protein ligase binding GO:0044389 IPI
Biological Process
    regulation of protein phosphorylation GO:0001932 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    defense response GO:0006952 IBA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IBA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 NAS
    regulation of cell population proliferation GO:0042127 IBA
    response to peptide hormone GO:0043434 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    defense response to virus GO:0051607 IMP
    type I interferon-mediated signaling pathway GO:0060337 IBA
    type I interferon-mediated signaling pathway GO:0060337 IMP
    negative regulation of type I interferon-mediated signaling pathway GO:0060339 IMP
    regulation of mitochondrial fission GO:0090140 IMP
Subcellular Localization
    chromatin GO:0000785 IC
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    ISGF3 complex GO:0070721 IBA
    ISGF3 complex GO:0070721 IPI
    RNA polymerase II transcription regulator complex GO:0090575 NAS
 Experiment description of studies that identified STAT2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STAT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF692  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 FAM196A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 FBXO45 200933
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CUL1 8454
Affinity Capture-Western Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 GSK3A 2931
Biochemical Activity Homo sapiens
7 STAT6 6778
Affinity Capture-Western Homo sapiens
8 MYCBP2 23077
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GSK3B 2932
Biochemical Activity Homo sapiens
10 PDLIM2  
Affinity Capture-Western Homo sapiens
11 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
13 USP1 7398
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 INPPL1 3636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 GYPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PFN1 5216
Proximity Label-MS Homo sapiens
17 AURKA 6790
Reconstituted Complex Homo sapiens
18 SMARCC1 6599
Affinity Capture-Western Homo sapiens
19 MEN1 4221
Affinity Capture-MS Homo sapiens
20 SMARCE1 6605
Affinity Capture-Western Homo sapiens
21 HSPA4 3308
Co-fractionation Homo sapiens
22 RBX1 9978
Affinity Capture-Western Homo sapiens
23 HSPB1 3315
Affinity Capture-Western Homo sapiens
24 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
25 CREBBP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 GAA 2548
Two-hybrid Homo sapiens
27 LIPT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
29 C15orf59  
Affinity Capture-MS Homo sapiens
30 DDX58 23586
Affinity Capture-RNA Homo sapiens
31 FBXO11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SELO 83642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 Nup214  
Affinity Capture-MS Mus musculus
34 USP18  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
35 DCST1  
Affinity Capture-Western Homo sapiens
36 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
37 IWS1  
Two-hybrid Homo sapiens
38 IFNAR2 3455
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 STAT1 6772
Co-purification Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
40 FNTA 2339
Two-hybrid Homo sapiens
41 IFNAR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 UBR4 23352
Affinity Capture-Western Homo sapiens
43 NPAS1  
Affinity Capture-MS Homo sapiens
44 IARS2 55699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
46 DPP9 91039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CDH1 999
Proximity Label-MS Homo sapiens
48 FBXW7  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
49 TACC1 6867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 KLHL10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 IRF9 10379
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PML 5371
Affinity Capture-Western Homo sapiens
53 EP400  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 INTS6 26512
Affinity Capture-MS Homo sapiens
55 RCAN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 MED14  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
57 EP300 2033
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
58 PDF  
Affinity Capture-MS Homo sapiens
59 CAPN2 824
Affinity Capture-MS Homo sapiens
60 SMARCC2 6601
Affinity Capture-Western Homo sapiens
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