Gene description for SETD1B
Gene name SET domain containing 1B
Gene symbol SETD1B
Other names/aliases KMT2G
Set1B
Species Homo sapiens
 Database cross references - SETD1B
ExoCarta ExoCarta_23067
Entrez Gene 23067
HGNC 29187
MIM 611055
UniProt Q9UPS6  
 SETD1B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SETD1B
Molecular Function
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    histone methyltransferase activity (H3-K4 specific) GO:0042800 IDA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    histone H3-K4 methylation GO:0051568 IDA
    chromatin organization GO:0006325 TAS
Subcellular Localization
    histone methyltransferase complex GO:0035097 IDA
    nuclear speck GO:0016607 IEA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
    Set1C/COMPASS complex GO:0048188 IDA
    chromosome GO:0005694 IEA
 Experiment description of studies that identified SETD1B in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SETD1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SETD1B is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





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