Gene description for INTS1
Gene name integrator complex subunit 1
Gene symbol INTS1
Other names/aliases INT1
NET28
Species Homo sapiens
 Database cross references - INTS1
ExoCarta ExoCarta_26173
Vesiclepedia VP_26173
Entrez Gene 26173
HGNC 24555
MIM 611345
UniProt Q8N201  
 INTS1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for INTS1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    inner cell mass cell proliferation GO:0001833 IEA
    embryo implantation GO:0007566 IEA
    snRNA processing GO:0016180 IDA
    snRNA processing GO:0016180 NAS
    regulation of transcription elongation by RNA polymerase II GO:0034243 NAS
    U2 snRNA 3'-end processing GO:0034474 IBA
    negative regulation of apoptotic process GO:0043066 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 HDA
    nuclear membrane GO:0031965 IEA
    integrator complex GO:0032039 IBA
    integrator complex GO:0032039 IDA
    integrator complex GO:0032039 NAS
 Experiment description of studies that identified INTS1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for INTS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGOLN2 10618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 INTS4  
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 STARD3NL 83930
Affinity Capture-MS Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 ZMYND8 23613
Affinity Capture-MS Homo sapiens
7 USP43  
Affinity Capture-MS Homo sapiens
8 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
9 SSR2  
Affinity Capture-MS Homo sapiens
10 HCST  
Affinity Capture-MS Homo sapiens
11 RPA2 6118
Affinity Capture-MS Homo sapiens
12 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
13 TMEM184A  
Affinity Capture-MS Homo sapiens
14 INTS10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 HCRTR2  
Affinity Capture-MS Homo sapiens
16 FPR1  
Affinity Capture-MS Homo sapiens
17 NABP2  
Affinity Capture-MS Homo sapiens
18 C7orf76  
Affinity Capture-MS Homo sapiens
19 FFAR1  
Affinity Capture-MS Homo sapiens
20 GPR150  
Affinity Capture-MS Homo sapiens
21 INTS9 55756
Affinity Capture-MS Homo sapiens
22 TCEA1 6917
Affinity Capture-MS Homo sapiens
23 TCEB3 6924
Affinity Capture-MS Homo sapiens
24 TCN2 6948
Affinity Capture-MS Homo sapiens
25 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
26 CYB5B 80777
Affinity Capture-MS Homo sapiens
27 TMEM130  
Affinity Capture-MS Homo sapiens
28 HLA-B 3106
Affinity Capture-MS Homo sapiens
29 FAM174A 345757
Affinity Capture-MS Homo sapiens
30 Ints4  
Affinity Capture-MS Mus musculus
31 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GPR55  
Affinity Capture-MS Homo sapiens
33 INTS12  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 P2RY8  
Affinity Capture-MS Homo sapiens
36 JTB 10899
Affinity Capture-MS Homo sapiens
37 DGCR2 9993
Affinity Capture-MS Homo sapiens
38 INTS6 26512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 F2RL1  
Affinity Capture-MS Homo sapiens
40 MECP2 4204
Affinity Capture-MS Homo sapiens
41 IL13RA2 3598
Affinity Capture-MS Homo sapiens
42 NPAS1  
Affinity Capture-MS Homo sapiens
43 PTH1R  
Affinity Capture-MS Homo sapiens
44 MAS1  
Affinity Capture-MS Homo sapiens
45 PROKR1  
Affinity Capture-MS Homo sapiens
46 MTNR1B  
Two-hybrid Homo sapiens
47 BSG 682
Affinity Capture-MS Homo sapiens
48 GZMH  
Affinity Capture-MS Homo sapiens
49 CD70 970
Affinity Capture-MS Homo sapiens
50 KLRC4  
Affinity Capture-MS Homo sapiens
51 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
52 GCGR  
Affinity Capture-MS Homo sapiens
53 C7orf26  
Affinity Capture-MS Homo sapiens
54 CTDP1 9150
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
55 SUPT5H 6829
Affinity Capture-MS Homo sapiens
56 ACACA 31
Positive Genetic Homo sapiens
57 FZD10  
Affinity Capture-MS Homo sapiens
58 ILVBL 10994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 Ppp2ca 19052
Affinity Capture-MS Mus musculus
60 COMTD1 118881
Affinity Capture-MS Homo sapiens
61 IL2RA  
Affinity Capture-MS Homo sapiens
62 NTRK1 4914
Affinity Capture-MS Homo sapiens
63 GPR182  
Affinity Capture-MS Homo sapiens
64 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 INTS7  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
66 EED  
Affinity Capture-MS Homo sapiens
67 MLNR  
Affinity Capture-MS Homo sapiens
68 POLR2B 5431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
70 DDX26B  
Affinity Capture-MS Homo sapiens
71 P2RY2 5029
Affinity Capture-MS Homo sapiens
72 VIPR2  
Affinity Capture-MS Homo sapiens
73 ST8SIA1  
Affinity Capture-MS Homo sapiens
74 EFNA4  
Affinity Capture-MS Homo sapiens
75 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 FANCD2  
Affinity Capture-MS Homo sapiens
77 POLR2H 5437
Affinity Capture-MS Homo sapiens
78 BTNL9  
Affinity Capture-MS Homo sapiens
79 SIRT7  
Affinity Capture-MS Homo sapiens
80 NPTN 27020
Affinity Capture-MS Homo sapiens
81 POLR2E 5434
Affinity Capture-MS Homo sapiens
82 CMKLR1 1240
Affinity Capture-MS Homo sapiens
83 MGARP  
Affinity Capture-MS Homo sapiens
84 CUL3 8452
Affinity Capture-MS Homo sapiens
85 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 HSD17B13  
Affinity Capture-MS Homo sapiens
87 CTAG2  
Affinity Capture-MS Homo sapiens
88 IQCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 OPRL1 4987
Affinity Capture-MS Homo sapiens
90 POLR2A 5430
Affinity Capture-MS Homo sapiens
91 OCIAD1 54940
Affinity Capture-MS Homo sapiens
92 SLC2A1 6513
Affinity Capture-MS Homo sapiens
93 C3orf18  
Affinity Capture-MS Homo sapiens
94 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
96 GPR45  
Affinity Capture-MS Homo sapiens
97 AQP3  
Affinity Capture-MS Homo sapiens
98 RPAP3 79657
Affinity Capture-MS Homo sapiens
99 ZNF687  
Affinity Capture-MS Homo sapiens
100 P2RY10  
Affinity Capture-MS Homo sapiens
101 KRAS 3845
Negative Genetic Homo sapiens
102 LPPR2  
Affinity Capture-MS Homo sapiens
103 CPSF3L 54973
Affinity Capture-MS Homo sapiens
104 INTS5 80789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 C9orf72  
Affinity Capture-MS Homo sapiens
106 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 CCDC8  
Affinity Capture-MS Homo sapiens
108 ASUN  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
109 AVPR2  
Affinity Capture-MS Homo sapiens
110 GPR17 2840
Affinity Capture-MS Homo sapiens
111 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
112 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 STK16 8576
Affinity Capture-MS Homo sapiens
114 POLR2F  
Affinity Capture-MS Homo sapiens
115 PARP1 142
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
116 OPALIN  
Affinity Capture-MS Homo sapiens
117 MFSD4  
Affinity Capture-MS Homo sapiens
118 OSTM1 28962
Affinity Capture-MS Homo sapiens
119 RPA1 6117
Affinity Capture-MS Homo sapiens
120 MEN1 4221
Affinity Capture-MS Homo sapiens
121 VWA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 RPAP2  
Affinity Capture-MS Homo sapiens
123 INTS8  
Affinity Capture-MS Homo sapiens
124 INTS2  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
125 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 POLR2K  
Affinity Capture-MS Homo sapiens
127 SLAMF1 6504
Affinity Capture-MS Homo sapiens
128 CD80 941
Affinity Capture-MS Homo sapiens
129 KIR2DS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 CIT 11113
Affinity Capture-MS Homo sapiens
131 XRCC6 2547
Proximity Label-MS Homo sapiens
132 INTS3 65123
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
133 SNW1 22938
Affinity Capture-MS Homo sapiens
134 VIPR1  
Affinity Capture-MS Homo sapiens
135 DRD4  
Affinity Capture-MS Homo sapiens
136 CDC5L 988
Affinity Capture-MS Homo sapiens
137 SSRP1 6749
Affinity Capture-MS Homo sapiens
138 B3GNT8  
Affinity Capture-MS Homo sapiens
139 CXCL16 58191
Affinity Capture-MS Homo sapiens
140 ADGRG2 10149
Affinity Capture-MS Homo sapiens
141 SKA1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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