Gene description for KPNA3
Gene name karyopherin alpha 3 (importin alpha 4)
Gene symbol KPNA3
Other names/aliases IPOA4
SRP1
SRP1gamma
SRP4
hSRP1
Species Homo sapiens
 Database cross references - KPNA3
ExoCarta ExoCarta_3839
Vesiclepedia VP_3839
Entrez Gene 3839
HGNC 6396
MIM 601892
UniProt O00505  
 KPNA3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Endothelial cells 26027894    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for KPNA3
Molecular Function
    protein binding GO:0005515 IPI
    nuclear localization sequence binding GO:0008139 IBA
    nuclear import signal receptor activity GO:0061608 IBA
Biological Process
    protein import into nucleus GO:0006606 ISS
    NLS-bearing protein import into nucleus GO:0006607 IBA
    symbiont entry into host cell GO:0046718 IEA
    protein-containing complex assembly GO:0065003 TAS
    viral penetration into host nucleus GO:0075732 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nuclear pore GO:0005643 TAS
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 NAS
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 NAS
    cytosol GO:0005829 TAS
    NLS-dependent protein nuclear import complex GO:0042564 IPI
    host cell GO:0043657 IEA
 Experiment description of studies that identified KPNA3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
13
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KPNA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2B 5431
Affinity Capture-MS Homo sapiens
2 MVP 9961
Two-hybrid Homo sapiens
3 BAHD1  
Two-hybrid Homo sapiens
4 HNRNPC 3183
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
5 RPL26L1 51121
Co-fractionation Homo sapiens
6 POLDIP3 84271
Affinity Capture-MS Homo sapiens
7 HDAC2 3066
Affinity Capture-MS Homo sapiens
8 VARS 7407
Co-fractionation Homo sapiens
9 COIL  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
10 EEF1G 1937
Co-fractionation Homo sapiens
11 KPNA1 3836
Co-fractionation Homo sapiens
12 Rcc1  
Affinity Capture-MS Mus musculus
13 TNPO1 3842
Co-fractionation Homo sapiens
14 DYNC1I2 1781
Co-fractionation Homo sapiens
15 REL 5966
Co-fractionation Homo sapiens
16 KPNB1 3837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
17 NOP56 10528
Affinity Capture-MS Homo sapiens
18 NMNAT1  
Two-hybrid Homo sapiens
19 RPS19 6223
Co-fractionation Homo sapiens
20 USP9X 8239
Co-fractionation Homo sapiens
21 RANBP2 5903
Affinity Capture-MS Homo sapiens
22 POM121  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 KPNA2 3838
Co-fractionation Homo sapiens
24 GRB10 2887
Two-hybrid Homo sapiens
25 SLC5A11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 CCDC102B  
Two-hybrid Homo sapiens
27 ZBTB24  
Two-hybrid Homo sapiens
28 MYOD1  
Two-hybrid Homo sapiens
29 APEX1 328
Affinity Capture-MS Homo sapiens
30 TOP2A 7153
Co-fractionation Homo sapiens
31 NFE2L2 4780
Two-hybrid Homo sapiens
32 NCBP1 4686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PCNT  
Proximity Label-MS Homo sapiens
34 KIF22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 MAP1B 4131
Co-fractionation Homo sapiens
36 NOLC1 9221
Affinity Capture-MS Homo sapiens
37 CTDSPL2  
Affinity Capture-MS Homo sapiens
38 NUP153 9972
Affinity Capture-MS Homo sapiens
39 FBXW7  
Affinity Capture-MS Homo sapiens
40 APOL6  
Two-hybrid Homo sapiens
41 NPM1 4869
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
42 ACTR1A 10121
Co-fractionation Homo sapiens
43 ZNF512B  
Affinity Capture-MS Homo sapiens
44 CBX1 10951
Affinity Capture-MS Homo sapiens
45 MCM6 4175
Co-fractionation Homo sapiens
46 HMGA1 3159
Affinity Capture-MS Homo sapiens
47 IPO8 10526
Co-fractionation Homo sapiens
48 RCC1 1104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
49 BRD4 23476
Affinity Capture-MS Homo sapiens
50 SLX4  
Affinity Capture-MS Homo sapiens
51 ATG16L1 55054
Affinity Capture-MS Homo sapiens
52 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 MYCN  
Affinity Capture-MS Homo sapiens
54 GPS1 2873
Co-fractionation Homo sapiens
55 SERBP1 26135
Affinity Capture-MS Homo sapiens
56 TEX37  
Two-hybrid Homo sapiens
57 CLGN 1047
Co-fractionation Homo sapiens
58 CTCF  
Co-fractionation Homo sapiens
59 FAS 355
Proximity Label-MS Homo sapiens
60 POLR2K  
Affinity Capture-MS Homo sapiens
61 GATA6  
Two-hybrid Homo sapiens
62 RPS23 6228
Co-fractionation Homo sapiens
63 BOD1L1 259282
Co-fractionation Homo sapiens
64 POM121C  
Affinity Capture-MS Homo sapiens
65 C10orf12  
Affinity Capture-MS Homo sapiens
66 RNF4 6047
Affinity Capture-MS Homo sapiens
67 DDX21 9188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
68 MEPCE 56257
Affinity Capture-MS Homo sapiens
69 SAE1 10055
Affinity Capture-MS Homo sapiens
70 PHAX  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
71 FAM204A  
Affinity Capture-MS Homo sapiens
72 HSP90B1 7184
Co-fractionation Homo sapiens
73 MAPRE1 22919
Affinity Capture-MS Homo sapiens
74 ACIN1 22985
Co-fractionation Homo sapiens
75 COPB1 1315
Co-fractionation Homo sapiens
76 KPNA4 3840
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
77 SNRNP200 23020
Co-fractionation Homo sapiens
78 ACACA 31
Negative Genetic Homo sapiens
79 SMARCA4 6597
Affinity Capture-MS Homo sapiens
80 NOL7  
Affinity Capture-MS Homo sapiens
81 TUBA1B 10376
Co-fractionation Homo sapiens
82 GTF2H1 2965
Two-hybrid Homo sapiens
83 BARD1 580
Affinity Capture-MS Homo sapiens
84 NTRK1 4914
Affinity Capture-MS Homo sapiens
85 CBX5 23468
Affinity Capture-MS Homo sapiens
86 KMT2E  
Affinity Capture-MS Homo sapiens
87 Mki67 17345
Affinity Capture-MS Mus musculus
88 BPTF 2186
Co-fractionation Homo sapiens
89 ZNF131  
Reconstituted Complex Homo sapiens
90 HUWE1 10075
Co-fractionation Homo sapiens
91 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
92 COPS3 8533
Co-fractionation Homo sapiens
93 POLR3C 10623
Two-hybrid Homo sapiens
94 NFKB2 4791
Co-fractionation Homo sapiens
95 SDPR 8436
Co-fractionation Homo sapiens
96 H2AFY 9555
Co-fractionation Homo sapiens
97 Ksr1  
Affinity Capture-MS Mus musculus
98 Ncbp2  
Affinity Capture-MS Mus musculus
99 MED9  
Affinity Capture-MS Homo sapiens
100 IPO9 55705
Co-fractionation Homo sapiens
101 RAN 5901
Affinity Capture-MS Homo sapiens
102 CD3EAP  
Proximity Label-MS Homo sapiens
103 RSL1D1 26156
Affinity Capture-MS Homo sapiens
104 ZNF326 284695
Affinity Capture-MS Homo sapiens
105 C16orf72 29035
Affinity Capture-MS Homo sapiens
106 OGT 8473
Reconstituted Complex Homo sapiens
107 GTF3C3 9330
Co-fractionation Homo sapiens
108 USP42  
Affinity Capture-MS Homo sapiens
109 HADHB 3032
Co-fractionation Homo sapiens
110 HADHA 3030
Co-fractionation Homo sapiens
111 CANX 821
Co-fractionation Homo sapiens
112 TP53BP1 7158
Affinity Capture-MS Homo sapiens
113 XPO1 7514
Affinity Capture-MS Homo sapiens
114 NCBP2 22916
Affinity Capture-MS Homo sapiens
115 FAM50B  
Two-hybrid Homo sapiens
116 UBXN7 26043
Affinity Capture-MS Homo sapiens
117 Kifc1  
Affinity Capture-MS Mus musculus
118 NFKBIA  
Co-fractionation Homo sapiens
119 NPM3 10360
Affinity Capture-MS Homo sapiens
120 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 ATM 472
Two-hybrid Homo sapiens
122 MRGBP  
Affinity Capture-MS Homo sapiens
123 MCM4 4173
Co-fractionation Homo sapiens
124 TSSC4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
125 NUP214 8021
Affinity Capture-MS Homo sapiens
126 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
127 NT5C2 22978
Co-fractionation Homo sapiens
128 PCBP1 5093
Affinity Capture-MS Homo sapiens
129 FAM90A1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
130 Nup107  
Affinity Capture-MS Mus musculus
131 Mta2 23942
Affinity Capture-MS Mus musculus
132 LTV1  
Co-fractionation Homo sapiens
133 TMCO1 54499
Co-fractionation Homo sapiens
134 ZMYND8 23613
Affinity Capture-MS Homo sapiens
135 NACC1 112939
Affinity Capture-Western Homo sapiens
136 KAT5  
Two-hybrid Homo sapiens
137 NFKB1 4790
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
138 RANBP1 5902
Affinity Capture-MS Homo sapiens
139 RPL11 6135
Co-fractionation Homo sapiens
140 LMNA 4000
Co-fractionation Homo sapiens
141 BRD3 8019
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
142 MED14  
Affinity Capture-MS Homo sapiens
143 ZCCHC12  
Two-hybrid Homo sapiens
144 RBBP4 5928
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
145 COPS2 9318
Co-fractionation Homo sapiens
146 FTL 2512
Two-hybrid Homo sapiens
147 RELA 5970
Co-fractionation Homo sapiens
148 ARRB2 409
Affinity Capture-MS Homo sapiens
149 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
150 ESR2  
Two-hybrid Homo sapiens
151 PARP1 142
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
152 BKRF1  
Affinity Capture-MS
153 ILF3 3609
Affinity Capture-MS Homo sapiens
154 FBXL6  
Affinity Capture-MS Homo sapiens
155 MTA1 9112
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
156 UVSSA  
Two-hybrid Homo sapiens
157 USP36  
Affinity Capture-MS Homo sapiens
158 MEN1 4221
Affinity Capture-MS Homo sapiens
159 RRP1 8568
Affinity Capture-MS Homo sapiens
160 KPNA6 23633
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
161 IER2 9592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
163 THRAP3 9967
Co-fractionation Homo sapiens
164 HSPB1 3315
Two-hybrid Homo sapiens
165 ZNF764 92595
Two-hybrid Homo sapiens
166 MAT2B 27430
Two-hybrid Homo sapiens
167 GNL1 2794
Co-fractionation Homo sapiens
168 SIRT1  
Affinity Capture-MS Homo sapiens
169 CUX2 23316
Affinity Capture-MS Homo sapiens
170 ERCC3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
171 NUP50 10762
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
172 PPM1D  
Affinity Capture-MS Homo sapiens
173 HEXIM2  
Two-hybrid Homo sapiens
174 MMS19 64210
Co-fractionation Homo sapiens
175 H3F3A 3020
Co-fractionation Homo sapiens
176 ARRB1 408
Affinity Capture-MS Homo sapiens
177 CYHR1  
Two-hybrid Homo sapiens
178 HSF1  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 ZCCHC10  
Two-hybrid Homo sapiens
180 B2M 567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 CIT 11113
Affinity Capture-MS Homo sapiens
182 ANKRD11 29123
Two-hybrid Homo sapiens
183 Ranbp2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
184 EPHA2 1969
Two-hybrid Homo sapiens
185 LDLR 3949
Negative Genetic Homo sapiens
186 HNRNPU 3192
Affinity Capture-MS Homo sapiens
187 C9orf72  
Affinity Capture-MS Homo sapiens
188 NFKBIB  
Co-fractionation Homo sapiens
189 NRD1 4898
Co-fractionation Homo sapiens
190 RPA3 6119
Proximity Label-MS Homo sapiens
191 RPRD1A  
Two-hybrid Homo sapiens
192 CUL4A 8451
Affinity Capture-MS Homo sapiens
193 L3MBTL4  
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here