Gene description for PRKCD
Gene name	protein kinase C, delta
Gene symbol	PRKCD
Other names/aliases	ALPS3 CVID9 MAY1 PKCD nPKC-delta
Species	Homo sapiens
Database cross references - PRKCD
ExoCarta	ExoCarta_5580
Entrez Gene	5580
HGNC	9399
MIM	176977
UniProt	Q05655
PRKCD identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Urine	19056867

Gene ontology annotations for PRKCD

Molecular Function     protein binding GO:0005515 IPI     metal ion binding GO:0046872 IEA     protein serine/threonine kinase activity GO:0004674 IDA     ATP binding GO:0005524 IEA     enzyme activator activity GO:0008047 IDA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA     insulin receptor substrate binding GO:0043560 ISS     protein kinase C activity GO:0004697 ISS     enzyme binding GO:0019899 IPI     calcium-independent protein kinase C activity GO:0004699 TAS Biological Process     programmed cell death GO:0012501 TAS     innate immune response GO:0045087 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IEA     positive regulation of ceramide biosynthetic process GO:2000304 IMP     negative regulation of platelet aggregation GO:0090331 ISS     regulation of actin cytoskeleton organization GO:0032956 IMP     negative regulation of protein binding GO:0032091 TAS     positive regulation of apoptotic signaling pathway GO:2001235 IEA     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 ISS     negative regulation of MAP kinase activity GO:0043407 IMP     negative regulation of inflammatory response GO:0050728 IC     interferon-gamma-mediated signaling pathway GO:0060333 TAS     positive regulation of sphingomyelin catabolic process GO:2000755 IMP     cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     gene expression GO:0010467 TAS     cell cycle GO:0007049 IEA     peptidyl-threonine phosphorylation GO:0018107 IDA     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     positive regulation of protein dephosphorylation GO:0035307 IMP     protein phosphorylation GO:0006468 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     immunoglobulin mediated immune response GO:0016064 IEA     negative regulation of insulin receptor signaling pathway GO:0046627 TAS     regulation of receptor activity GO:0010469 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     negative regulation of actin filament polymerization GO:0030837 ISS     positive regulation of phospholipid scramblase activity GO:1900163 IMP     negative regulation of glial cell apoptotic process GO:0034351 IMP     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     neutrophil activation GO:0042119 IDA     signal transduction GO:0007165 TAS     apoptotic process GO:0006915 TAS     termination of signal transduction GO:0023021 IMP     positive regulation of response to DNA damage stimulus GO:2001022 IMP     interleukin-10 production GO:0032613 IEA     cellular senescence GO:0090398 IMP     activation of phospholipase C activity GO:0007202 TAS     B cell proliferation GO:0042100 IEA     defense response to bacterium GO:0042742 ISS     blood coagulation GO:0007596 TAS     platelet activation GO:0030168 TAS     positive regulation of superoxide anion generation GO:0032930 IMP     cytokine-mediated signaling pathway GO:0019221 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     protein stabilization GO:0050821 NAS     positive regulation of glucosylceramide catabolic process GO:2000753 IMP     negative regulation of filopodium assembly GO:0051490 ISS     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 TAS     interleukin-12 production GO:0032615 IEA Subcellular Localization     nucleus GO:0005634 IDA     nuclear matrix GO:0016363 IEA     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 TAS     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 TAS     perinuclear region of cytoplasm GO:0048471 IEA     cell-cell junction GO:0005911 IEA     cytoplasm GO:0005737 IDA     mitochondrion GO:0005739 IEA     endoplasmic reticulum GO:0005783 IDA