Gene description for HIST1H2BC
Gene name histone cluster 1, H2bc
Gene symbol HIST1H2BC
Other names/aliases H2B.1
H2B/l
H2BFL
dJ221C16.3
Species Homo sapiens
 Database cross references - HIST1H2BC
ExoCarta ExoCarta_8347
Vesiclepedia VP_8347
Entrez Gene 8347
HGNC 4757
MIM 602847
UniProt P62807  
 HIST1H2BC identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Endothelial cells 26027894    
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for HIST1H2BC
Molecular Function
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IEA
    identical protein binding GO:0042802 IPI
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    innate immune response in mucosa GO:0002227 IDA
    nucleosome assembly GO:0006334 NAS
    antibacterial humoral response GO:0019731 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    nucleosome GO:0000786 NAS
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST1H2BC in exosomes
1
Experiment ID 76
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 282
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 283
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
4
Experiment ID 285
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
5
Experiment ID 286
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
6
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
7
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
8
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
9
Experiment ID 139
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
10
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
11
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
12
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
13
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
14
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
15
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
16
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
17
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HIST1H2BC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Cross-Linking-MS (XL-MS) Homo sapiens
3 AFG3L2 10939
Cross-Linking-MS (XL-MS) Homo sapiens
4 SMC3 9126
Cross-Linking-MS (XL-MS) Homo sapiens
5 SMARCA2 6595
Cross-Linking-MS (XL-MS) Homo sapiens
6 KMT2C 58508
Cross-Linking-MS (XL-MS) Homo sapiens
7 NOLC1 9221
Cross-Linking-MS (XL-MS) Homo sapiens
8 JMJD1C 221037
Cross-Linking-MS (XL-MS) Homo sapiens
9 CENPE 1062
Cross-Linking-MS (XL-MS) Homo sapiens
10 EIF3C 8663
Cross-Linking-MS (XL-MS) Homo sapiens
11 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
12 AKAP4  
Cross-Linking-MS (XL-MS) Homo sapiens
13 PPIL4  
Cross-Linking-MS (XL-MS) Homo sapiens
14 SSB 6741
Cross-Linking-MS (XL-MS) Homo sapiens
15 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
16 BTF3 689
Affinity Capture-MS Homo sapiens
17 NFATC1 4772
Affinity Capture-MS Homo sapiens
18 ABCF1 23
Cross-Linking-MS (XL-MS) Homo sapiens
19 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
20 ARL6IP4  
Cross-Linking-MS (XL-MS) Homo sapiens
21 MAP4 4134
Cross-Linking-MS (XL-MS) Homo sapiens
22 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
23 NUMA1 4926
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
24 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
25 DCTN2 10540
Cross-Linking-MS (XL-MS) Homo sapiens
26 VHL  
Affinity Capture-MS Homo sapiens
27 CAND1 55832
Cross-Linking-MS (XL-MS) Homo sapiens
28 PSMD10 5716
Affinity Capture-MS Homo sapiens
29 SBNO1 55206
Cross-Linking-MS (XL-MS) Homo sapiens
30 DNAJB3 414061
Cross-Linking-MS (XL-MS) Homo sapiens
31 LMNA 4000
Cross-Linking-MS (XL-MS) Homo sapiens
32 SNRPD2 6633
Cross-Linking-MS (XL-MS) Homo sapiens
33 RPS3 6188
Cross-Linking-MS (XL-MS) Homo sapiens
34 PTGES2 80142
Cross-Linking-MS (XL-MS) Homo sapiens
35 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
36 MYO1H  
Cross-Linking-MS (XL-MS) Homo sapiens
37 PSIP1 11168
Cross-Linking-MS (XL-MS) Homo sapiens
38 CAPZB 832
Cross-Linking-MS (XL-MS) Homo sapiens
39 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
40 RUVBL1 8607
Cross-Linking-MS (XL-MS) Homo sapiens
41 GSPT2 23708
Cross-Linking-MS (XL-MS) Homo sapiens
42 SAE1 10055
Cross-Linking-MS (XL-MS) Homo sapiens
43 CEP104  
Cross-Linking-MS (XL-MS) Homo sapiens
44 IFT74 80173
Cross-Linking-MS (XL-MS) Homo sapiens
45 MCM2 4171
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
46 H1FX 8971
Cross-Linking-MS (XL-MS) Homo sapiens
47 C18orf25 147339
Cross-Linking-MS (XL-MS) Homo sapiens
48 ZNF638 27332
Cross-Linking-MS (XL-MS) Homo sapiens
49 RRP12 23223
Cross-Linking-MS (XL-MS) Homo sapiens
50 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
51 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
52 MEF2A  
Affinity Capture-MS Homo sapiens
53 RPL24 6152
Cross-Linking-MS (XL-MS) Homo sapiens
54 NPM1 4869
Affinity Capture-MS Homo sapiens
55 SRRM2 23524
Cross-Linking-MS (XL-MS) Homo sapiens
56 C4orf27  
Reconstituted Complex Homo sapiens
57 H2AFY2 55506
Cross-Linking-MS (XL-MS) Homo sapiens
58 TRO  
Cross-Linking-MS (XL-MS) Homo sapiens
59 ITGA4 3676
Affinity Capture-MS Homo sapiens
60 GNL3 26354
Cross-Linking-MS (XL-MS) Homo sapiens
61 PHF3  
Cross-Linking-MS (XL-MS) Homo sapiens
62 MTDH 92140
Cross-Linking-MS (XL-MS) Homo sapiens
63 NME2 4831
Affinity Capture-MS Homo sapiens
64 RPS11 6205
Cross-Linking-MS (XL-MS) Homo sapiens
65 CLASP2 23122
Cross-Linking-MS (XL-MS) Homo sapiens
66 HIST3H2BB 128312
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
67 PAK3  
Cross-Linking-MS (XL-MS) Homo sapiens
68 GTF2I 2969
Cross-Linking-MS (XL-MS) Homo sapiens
69 CHMP4C 92421
Affinity Capture-MS Homo sapiens
70 H2AFZ 3015
Cross-Linking-MS (XL-MS) Homo sapiens
71 BRPF1  
Cross-Linking-MS (XL-MS) Homo sapiens
72 DLD 1738
Affinity Capture-MS Homo sapiens
73 SCAF1  
Cross-Linking-MS (XL-MS) Homo sapiens
74 SLTM 79811
Cross-Linking-MS (XL-MS) Homo sapiens
75 MYH10 4628
Cross-Linking-MS (XL-MS) Homo sapiens
76 COX15 1355
Affinity Capture-MS Homo sapiens
77 NEB 4703
Cross-Linking-MS (XL-MS) Homo sapiens
78 TOP2B 7155
Cross-Linking-MS (XL-MS) Homo sapiens
79 CDK5 1020
Cross-Linking-MS (XL-MS) Homo sapiens
80 MAP1B 4131
Cross-Linking-MS (XL-MS) Homo sapiens
81 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
82 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
83 XRN1 54464
Cross-Linking-MS (XL-MS) Homo sapiens
84 A2M 2
Cross-Linking-MS (XL-MS) Homo sapiens
85 RALB 5899
Cross-Linking-MS (XL-MS) Homo sapiens
86 PSMD14 10213
Affinity Capture-MS Homo sapiens
87 ABCF2 10061
Cross-Linking-MS (XL-MS) Homo sapiens
88 FMR1 2332
Cross-Linking-MS (XL-MS) Homo sapiens
89 CHMP4B 128866
Cross-Linking-MS (XL-MS) Homo sapiens
90 LRRFIP1 9208
Cross-Linking-MS (XL-MS) Homo sapiens
91 TNRC18  
Cross-Linking-MS (XL-MS) Homo sapiens
92 MYH9 4627
Cross-Linking-MS (XL-MS) Homo sapiens
93 RAN 5901
Cross-Linking-MS (XL-MS) Homo sapiens
94 TTN 7273
Cross-Linking-MS (XL-MS) Homo sapiens
95 CKAP5 9793
Cross-Linking-MS (XL-MS) Homo sapiens
96 SPAG17  
Cross-Linking-MS (XL-MS) Homo sapiens
97 RPL36 25873
Cross-Linking-MS (XL-MS) Homo sapiens
98 PPME1 51400
Cross-Linking-MS (XL-MS) Homo sapiens
99 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
100 CHD5 26038
Cross-Linking-MS (XL-MS) Homo sapiens
101 MYH11 4629
Cross-Linking-MS (XL-MS) Homo sapiens
102 ENY2 56943
Cross-Linking-MS (XL-MS) Homo sapiens
103 MAGOH 4116
Affinity Capture-MS Homo sapiens
104 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
105 NOL8  
Cross-Linking-MS (XL-MS) Homo sapiens
106 DDX39B 7919
Cross-Linking-MS (XL-MS) Homo sapiens
107 AHCTF1 25909
Cross-Linking-MS (XL-MS) Homo sapiens
108 NCL 4691
Cross-Linking-MS (XL-MS) Homo sapiens
109 H2AFY 9555
Cross-Linking-MS (XL-MS) Homo sapiens
110 DDX27 55661
Cross-Linking-MS (XL-MS) Homo sapiens
111 PRMT8  
Cross-Linking-MS (XL-MS) Homo sapiens
112 STAG2 10735
Cross-Linking-MS (XL-MS) Homo sapiens
113 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
114 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
115 SMARCC2 6601
Cross-Linking-MS (XL-MS) Homo sapiens
116 LARP1 23367
Cross-Linking-MS (XL-MS) Homo sapiens
117 HMGN3  
Cross-Linking-MS (XL-MS) Homo sapiens
118 HMGN1  
Cross-Linking-MS (XL-MS) Homo sapiens
119 PCDHGA4  
Cross-Linking-MS (XL-MS) Homo sapiens
120 HNRNPD 3184
Affinity Capture-MS Homo sapiens
121 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
122 HIST1H2AD 3013
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
123 TMPO 7112
Affinity Capture-MS Homo sapiens
124 PDAP1 11333
Cross-Linking-MS (XL-MS) Homo sapiens
125 CPSF1 29894
Cross-Linking-MS (XL-MS) Homo sapiens
126 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
127 SMCHD1 23347
Cross-Linking-MS (XL-MS) Homo sapiens
128 KMT2A  
Cross-Linking-MS (XL-MS) Homo sapiens
129 SHROOM3 57619
Cross-Linking-MS (XL-MS) Homo sapiens
130 TMA7 51372
Cross-Linking-MS (XL-MS) Homo sapiens
131 HIST2H3C 126961
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
132 SDHA 6389
Affinity Capture-MS Homo sapiens
133 ATP2B1 490
Cross-Linking-MS (XL-MS) Homo sapiens
134 LSM4 25804
Cross-Linking-MS (XL-MS) Homo sapiens
135 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
136 USP16  
Cross-Linking-MS (XL-MS) Homo sapiens
137 ERC2 26059
Cross-Linking-MS (XL-MS) Homo sapiens
138 BCAP31 10134
Cross-Linking-MS (XL-MS) Homo sapiens
139 MAP4K4 9448
Cross-Linking-MS (XL-MS) Homo sapiens
140 CUL3 8452
Affinity Capture-MS Homo sapiens
141 CDK5R2 8941
Cross-Linking-MS (XL-MS) Homo sapiens
142 PDIA3 2923
Cross-Linking-MS (XL-MS) Homo sapiens
143 AEBP1 165
Cross-Linking-MS (XL-MS) Homo sapiens
144 YY1 7528
Cross-Linking-MS (XL-MS) Homo sapiens
145 PRMT3 10196
Cross-Linking-MS (XL-MS) Homo sapiens
146 MCM4 4173
Cross-Linking-MS (XL-MS) Homo sapiens
147 EPRS 2058
Cross-Linking-MS (XL-MS) Homo sapiens
148 POLR2A 5430
Cross-Linking-MS (XL-MS) Homo sapiens
149 BASP1 10409
Cross-Linking-MS (XL-MS) Homo sapiens
150 HIST3H3 8290
Cross-Linking-MS (XL-MS) Homo sapiens
151 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
152 AP2M1 1173
Two-hybrid Homo sapiens
153 TOMM70A 9868
Cross-Linking-MS (XL-MS) Homo sapiens
154 PDCD4 27250
Cross-Linking-MS (XL-MS) Homo sapiens
155 EBNA1BP2 10969
Cross-Linking-MS (XL-MS) Homo sapiens
156 MAP2K3 5606
Cross-Linking-MS (XL-MS) Homo sapiens
157 HSP90AA4P 3323
Cross-Linking-MS (XL-MS) Homo sapiens
158 ACSL3 2181
Cross-Linking-MS (XL-MS) Homo sapiens
159 HIST1H2AH 85235
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
160 NEFM 4741
Cross-Linking-MS (XL-MS) Homo sapiens
161 PGM3 5238
Cross-Linking-MS (XL-MS) Homo sapiens
162 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
163 ZC3H18  
Cross-Linking-MS (XL-MS) Homo sapiens
164 DNAH1 25981
Cross-Linking-MS (XL-MS) Homo sapiens
165 EEF1A2 1917
Cross-Linking-MS (XL-MS) Homo sapiens
166 HP1BP3 50809
Cross-Linking-MS (XL-MS) Homo sapiens
167 SKIV2L2 23517
Cross-Linking-MS (XL-MS) Homo sapiens
168 UPF3B 65109
Cross-Linking-MS (XL-MS) Homo sapiens
169 RPL18 6141
Cross-Linking-MS (XL-MS) Homo sapiens
170 PARP1 142
Biochemical Activity Homo sapiens
171 SGTA 6449
Cross-Linking-MS (XL-MS) Homo sapiens
172 VDAC1 7416
Affinity Capture-MS Homo sapiens
173 SEPT7 989
Cross-Linking-MS (XL-MS) Homo sapiens
174 FSCN1 6624
Cross-Linking-MS (XL-MS) Homo sapiens
175 CEP350 9857
Cross-Linking-MS (XL-MS) Homo sapiens
176 HIST1H1T 3010
Cross-Linking-MS (XL-MS) Homo sapiens
177 RPL26 6154
Cross-Linking-MS (XL-MS) Homo sapiens
178 UPF2 26019
Cross-Linking-MS (XL-MS) Homo sapiens
179 MDM2  
Cross-Linking-MS (XL-MS) Homo sapiens
180 HIST1H2AC 8334
Cross-Linking-MS (XL-MS) Homo sapiens
181 HUWE1 10075
Cross-Linking-MS (XL-MS) Homo sapiens
182 H2AFX 3014
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
183 RRM1 6240
Cross-Linking-MS (XL-MS) Homo sapiens
184 SRP54 6729
Cross-Linking-MS (XL-MS) Homo sapiens
185 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
186 TP53BP2  
Two-hybrid Homo sapiens
187 RARA 5914
Affinity Capture-MS Homo sapiens
188 PRRC2A 7916
Cross-Linking-MS (XL-MS) Homo sapiens
189 DIDO1  
Cross-Linking-MS (XL-MS) Homo sapiens
190 SLC25A6 293
Cross-Linking-MS (XL-MS) Homo sapiens
191 HDGF 3068
Affinity Capture-MS Homo sapiens
192 H3F3A 3020
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
193 FSIP2 401024
Cross-Linking-MS (XL-MS) Homo sapiens
194 DLG3 1741
Affinity Capture-MS Homo sapiens
195 ATP1A3 478
Cross-Linking-MS (XL-MS) Homo sapiens
196 DPF2  
Cross-Linking-MS (XL-MS) Homo sapiens
197 EIF1AX 1964
Cross-Linking-MS (XL-MS) Homo sapiens
198 SUCLG2 8801
Cross-Linking-MS (XL-MS) Homo sapiens
199 MCM5 4174
Affinity Capture-MS Homo sapiens
200 JPH2 57158
Cross-Linking-MS (XL-MS) Homo sapiens
201 SMARCC1 6599
Cross-Linking-MS (XL-MS) Homo sapiens
202 PPP1CC 5501
Cross-Linking-MS (XL-MS) Homo sapiens
203 MEN1 4221
Affinity Capture-MS Homo sapiens
204 FAM3C 10447
Cross-Linking-MS (XL-MS) Homo sapiens
205 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
206 KNOP1 400506
Cross-Linking-MS (XL-MS) Homo sapiens
207 KIAA1109 84162
Cross-Linking-MS (XL-MS) Homo sapiens
208 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
209 SECISBP2L  
Cross-Linking-MS (XL-MS) Homo sapiens
210 FANCI 55215
Cross-Linking-MS (XL-MS) Homo sapiens
211 GPD1L 23171
Cross-Linking-MS (XL-MS) Homo sapiens
212 LOC102724334 102724334
Cross-Linking-MS (XL-MS) Homo sapiens
213 BCL10  
Affinity Capture-MS Homo sapiens
214 EIF4A3 9775
Affinity Capture-MS Homo sapiens
215 CNOT3 4849
Cross-Linking-MS (XL-MS) Homo sapiens
216 SIRT1  
Affinity Capture-MS Homo sapiens
217 PRRC2B  
Cross-Linking-MS (XL-MS) Homo sapiens
218 PARP2  
Biochemical Activity Homo sapiens
219 MAPK6  
Cross-Linking-MS (XL-MS) Homo sapiens
220 ESR1  
Reconstituted Complex Homo sapiens
221 DHX40  
Cross-Linking-MS (XL-MS) Homo sapiens
222 WDHD1  
Cross-Linking-MS (XL-MS) Homo sapiens
223 STRN4 29888
Cross-Linking-MS (XL-MS) Homo sapiens
224 EEF1A1P5 158078
Cross-Linking-MS (XL-MS) Homo sapiens
225 GAPDH 2597
Cross-Linking-MS (XL-MS) Homo sapiens
226 EZH2  
Cross-Linking-MS (XL-MS) Homo sapiens
227 VPS26B 112936
Cross-Linking-MS (XL-MS) Homo sapiens
228 EIF4B 1975
Cross-Linking-MS (XL-MS) Homo sapiens
229 OSBPL9 114883
Cross-Linking-MS (XL-MS) Homo sapiens
230 HNRNPA1L2 144983
Cross-Linking-MS (XL-MS) Homo sapiens
231 ANKRD11 29123
Cross-Linking-MS (XL-MS) Homo sapiens
232 RPRD1B 58490
Cross-Linking-MS (XL-MS) Homo sapiens
233 NAA15 80155
Cross-Linking-MS (XL-MS) Homo sapiens
234 XRCC6 2547
Proximity Label-MS Homo sapiens
235 AIMP1 9255
Cross-Linking-MS (XL-MS) Homo sapiens
236 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
237 AR 367
Affinity Capture-MS Homo sapiens
238 TRIM29 23650
Affinity Capture-MS Homo sapiens
239 PWWP2A  
Cross-Linking-MS (XL-MS) Homo sapiens
240 AP3D1 8943
Cross-Linking-MS (XL-MS) Homo sapiens
241 DDX56  
Affinity Capture-MS Homo sapiens
242 TIMM44 10469
Cross-Linking-MS (XL-MS) Homo sapiens
243 EIF5 1983
Cross-Linking-MS (XL-MS) Homo sapiens
244 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
245 PNN 5411
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which HIST1H2BC is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
E3 ubiquitin ligases ubiquitinate target proteins TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones TAS Reactome
HATs acetylate histones IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Protein ubiquitination TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome





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