Gene description for NIN
Gene name ninein (GSK3B interacting protein)
Gene symbol NIN
Other names/aliases SCKL7
Species Homo sapiens
 Database cross references - NIN
ExoCarta ExoCarta_51199
Entrez Gene 51199
HGNC 14906
MIM 608684
UniProt Q8N4C6  
 NIN identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for NIN
Molecular Function
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    centrosome localization GO:0051642 TAS
    microtubule anchoring at centrosome GO:0034454 IEA
    centrosome-templated microtubule nucleation GO:0090222 IEA
Subcellular Localization
    centriole GO:0005814 IEA
    nucleolus GO:0005730 IDA
    spindle pole GO:0000922 IMP
    microtubule GO:0005874 IEA
    centrosome GO:0005813 IDA
 Experiment description of studies that identified NIN in exosomes
Experiment ID 44
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for NIN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKACA 5566
Biochemical Activity Homo sapiens
2 GSK3B 2932
Two-hybrid Homo sapiens
3 NIN 51199
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 STK6  
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which NIN is involved
No pathways found

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