Gene description for NFKB1
Gene name	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Gene symbol	NFKB1
Other names/aliases	EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50
Species	Homo sapiens
Database cross references - NFKB1
ExoCarta	ExoCarta_4790
Entrez Gene	4790
HGNC	7794
MIM	164011
UniProt	P19838
NFKB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for NFKB1

Molecular Function     RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 IDA     RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001227 IDA     chromatin binding GO:0003682 IBA     protein heterodimerization activity GO:0046982 IDA     protein binding GO:0005515 IPI     transcription regulatory region DNA binding GO:0044212 IDA     regulatory region DNA binding GO:0000975 IDA     transcription regulatory region sequence-specific DNA binding GO:0000976 IDA     protein homodimerization activity GO:0042803 IEA     transcription factor binding GO:0008134 IDA     RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IDA     heat shock protein binding GO:0031072 IEA     identical protein binding GO:0042802 IPI     RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA     double-stranded DNA binding GO:0003690 IEA     sequence-specific DNA binding transcription factor activity GO:0003700 IDA Biological Process     response to oxidative stress GO:0006979 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     cellular response to interleukin-6 GO:0071354 IMP     negative regulation of apoptotic process GO:0043066 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     cellular response to lipopolysaccharide GO:0071222 IMP     toll-like receptor 4 signaling pathway GO:0034142 TAS     positive regulation of lipid storage GO:0010884 IC     negative regulation of interleukin-12 biosynthetic process GO:0045083 IEA     membrane protein intracellular domain proteolysis GO:0031293 TAS     cellular response to peptide hormone stimulus GO:0071375 IMP     toll-like receptor 3 signaling pathway GO:0034138 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     T cell receptor signaling pathway GO:0050852 TAS     transcription from RNA polymerase II promoter GO:0006366 TAS     inflammatory response GO:0006954 TAS     negative regulation of cellular protein metabolic process GO:0032269 IC     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of type I interferon production GO:0032481 TAS     cellular response to mechanical stimulus GO:0071260 IEP     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     positive regulation of transcription, DNA-templated GO:0045893 NAS     NIK/NF-kappaB signaling GO:0038061 IBA     negative regulation of cholesterol transport GO:0032375 IC     positive regulation of hyaluronan biosynthetic process GO:1900127 IDA     apoptotic process GO:0006915 IEA     innate immune response GO:0045087 TAS     negative regulation of inflammatory response GO:0050728 IEA     positive regulation of miRNA metabolic process GO:2000630 IMP     toll-like receptor signaling pathway GO:0002224 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     positive regulation of macrophage derived foam cell differentiation GO:0010744 IC     negative regulation of vitamin D biosynthetic process GO:0010957 IC     positive regulation of canonical Wnt signaling pathway GO:0090263 IMP     I-kappaB kinase/NF-kappaB signaling GO:0007249 IBA     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     cellular response to nicotine GO:0071316 IMP     toll-like receptor 5 signaling pathway GO:0034146 TAS     negative regulation of calcidiol 1-monooxygenase activity GO:0010956 IDA     toll-like receptor 2 signaling pathway GO:0034134 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     response to copper ion GO:0046688 IEA     cellular response to interleukin-1 GO:0071347 IEP     Fc-epsilon receptor signaling pathway GO:0038095 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP Subcellular Localization     cytosol GO:0005829 TAS     nucleoplasm GO:0005654 TAS     I-kappaB/NF-kappaB complex GO:0033256 TAS     mitochondrion GO:0005739 IDA     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA