Gene description for POLDIP2
Gene name polymerase (DNA-directed), delta interacting protein 2
Gene symbol POLDIP2
Other names/aliases PDIP38
POLD4
p38
Species Homo sapiens
 Database cross references - POLDIP2
ExoCarta ExoCarta_26073
Vesiclepedia VP_26073
Entrez Gene 26073
HGNC 23781
MIM 611519
UniProt Q9Y2S7  
 POLDIP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for POLDIP2
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
Biological Process
    mitochondrion organization GO:0007005 IEA
    negative regulation of macroautophagy GO:0016242 IEA
    positive regulation of mitotic cell cycle GO:0045931 IEA
    positive regulation of focal adhesion assembly GO:0051894 IEA
    error-free translesion synthesis GO:0070987 IBA
    error-free translesion synthesis GO:0070987 IDA
    mitotic spindle assembly GO:0090307 IEA
    positive regulation of mitotic cytokinesis GO:1903490 IEA
    vascular associated smooth muscle cell proliferation GO:1990874 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IDA
    cell-cell junction GO:0005911 IEA
    midbody GO:0030496 IEA
    mitochondrial nucleoid GO:0042645 IBA
    mitochondrial nucleoid GO:0042645 IDA
    mitotic spindle GO:0072686 IEA
 Experiment description of studies that identified POLDIP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for POLDIP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REV1  
Two-hybrid Homo sapiens
2 MPST 4357
Co-fractionation Homo sapiens
3 GSTP1 2950
Co-fractionation Homo sapiens
4 LYRM2  
Affinity Capture-MS Homo sapiens
5 PMPCA 23203
Proximity Label-MS Homo sapiens
6 MBTD1  
Affinity Capture-MS Homo sapiens
7 MCM2 4171
Affinity Capture-MS Homo sapiens
8 ADCK3  
Affinity Capture-MS Homo sapiens
9 ZNF524  
Affinity Capture-MS Homo sapiens
10 ZNHIT2 741
Affinity Capture-MS Homo sapiens
11 TRIM66  
Affinity Capture-MS Homo sapiens
12 TRUB2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
13 UCHL1 7345
Co-fractionation Homo sapiens
14 CMPK1 51727
Co-fractionation Homo sapiens
15 MTG2  
Proximity Label-MS Homo sapiens
16 NGRN  
Proximity Label-MS Homo sapiens
17 CHCHD1  
Proximity Label-MS Homo sapiens
18 TAB1 10454
Two-hybrid Homo sapiens
19 PTP4A1 7803
Affinity Capture-MS Homo sapiens
20 NENF 29937
Co-fractionation Homo sapiens
21 NDUFA4 4697
Affinity Capture-MS Homo sapiens
22 XPNPEP3 63929
Affinity Capture-MS Homo sapiens
23 PARK7 11315
Co-fractionation Homo sapiens
24 MTRF1  
Proximity Label-MS Homo sapiens
25 GFM2 84340
Proximity Label-MS Homo sapiens
26 CCDC90B  
Proximity Label-MS Homo sapiens
27 GRHPR 9380
Co-fractionation Homo sapiens
28 DNAJC10 54431
Affinity Capture-MS Homo sapiens
29 NDUFS3 4722
Affinity Capture-MS Homo sapiens
30 TFAM 7019
Proximity Label-MS Homo sapiens
31 KIF23 9493
Affinity Capture-MS Homo sapiens
32 COQ9  
Affinity Capture-MS Homo sapiens
33 PTPMT1 114971
Affinity Capture-MS Homo sapiens
34 CHCHD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 NIT1 4817
Affinity Capture-MS Homo sapiens
36 HINT2 84681
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
37 BHLHA15  
Affinity Capture-MS Homo sapiens
38 CHCHD10  
Affinity Capture-MS Homo sapiens
39 FTSJ2 29960
Affinity Capture-MS Homo sapiens
40 MAD2L2 10459
Two-hybrid Homo sapiens
41 SPATA20  
Affinity Capture-MS Homo sapiens
42 MTUS2 23281
Two-hybrid Homo sapiens
43 DNAJB1 3337
Co-fractionation Homo sapiens
44 MRPS26 64949
Proximity Label-MS Homo sapiens
45 FAM136A 84908
Affinity Capture-MS Homo sapiens
46 EXD2  
Proximity Label-MS Homo sapiens
47 LACTB 114294
Affinity Capture-MS Homo sapiens
48 NKX2-5  
Affinity Capture-MS Homo sapiens
49 MECP2 4204
Affinity Capture-MS Homo sapiens
50 PMPCB 9512
Proximity Label-MS Homo sapiens
51 TACO1  
Proximity Label-MS Homo sapiens
52 ADCK4 79934
Affinity Capture-MS Homo sapiens
53 MTERF3  
Proximity Label-MS Homo sapiens
54 KIF14 9928
Affinity Capture-MS Homo sapiens
55 PCNA 5111
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
56 C1qbp 12261
Affinity Capture-MS Mus musculus
57 MDH2 4191
Proximity Label-MS Homo sapiens
58 ALAS1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
59 ATP5A1 498
Affinity Capture-MS Homo sapiens
60 C6orf203  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
61 FASTKD5  
Proximity Label-MS Homo sapiens
62 LSM14B 149986
Affinity Capture-MS Homo sapiens
63 NT5DC2 64943
Affinity Capture-MS Homo sapiens
64 TUFM 7284
Proximity Label-MS Homo sapiens
65 HSCB 150274
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
66 LHX1  
Affinity Capture-MS Homo sapiens
67 IDS  
Affinity Capture-MS Homo sapiens
68 RPA2 6118
Proximity Label-MS Homo sapiens
69 SPR 6697
Co-fractionation Homo sapiens
70 LRPPRC 10128
Proximity Label-MS Homo sapiens
71 POLDIP2 26073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 GFM1 85476
Proximity Label-MS Homo sapiens
73 ASCC2 84164
Two-hybrid Homo sapiens
74 ARRDC3 57561
Affinity Capture-MS Homo sapiens
75 COQ10B  
Affinity Capture-MS Homo sapiens
76 GALNS 2588
Affinity Capture-MS Homo sapiens
77 PAK7  
Affinity Capture-MS Homo sapiens
78 MTRF1L  
Proximity Label-MS Homo sapiens
79 DNAJC30  
Affinity Capture-MS Homo sapiens
80 MTMR4  
Affinity Capture-MS Homo sapiens
81 FAHD2A 51011
Co-fractionation Homo sapiens
82 CISD3 284106
Affinity Capture-MS Homo sapiens
83 TLX2  
Affinity Capture-MS Homo sapiens
84 C15orf48  
Affinity Capture-MS Homo sapiens
85 OTC 5009
Proximity Label-MS Homo sapiens
86 MRRF  
Proximity Label-MS Homo sapiens
87 UBE2H 7328
Affinity Capture-MS Homo sapiens
88 HTRA2 27429
Co-fractionation Homo sapiens
89 MRPS12  
Proximity Label-MS Homo sapiens
90 MTIF2 4528
Proximity Label-MS Homo sapiens
91 RC3H2  
Affinity Capture-MS Homo sapiens
92 POLN 353497
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
93 LAD1 3898
Co-fractionation Homo sapiens
94 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RMND1 55005
Proximity Label-MS Homo sapiens
96 COQ4  
Affinity Capture-MS Homo sapiens
97 EGFR 1956
Affinity Capture-MS Homo sapiens
98 DHRS4 10901
Affinity Capture-MS Homo sapiens
99 PDPK1 5170
Two-hybrid Homo sapiens
100 HDHD3 81932
Co-fractionation Homo sapiens
101 OCIAD1 54940
Affinity Capture-MS Homo sapiens
102 NXF1 10482
Affinity Capture-RNA Homo sapiens
103 AURKB 9212
Affinity Capture-MS Homo sapiens
104 CECR5 27440
Affinity Capture-MS Homo sapiens
105 C12orf65  
Proximity Label-MS Homo sapiens
106 MTG1  
Proximity Label-MS Homo sapiens
107 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
108 RPA3 6119
Proximity Label-MS Homo sapiens
109 SELENBP1 8991
Two-hybrid Homo sapiens
110 PTPDC1  
Affinity Capture-MS Homo sapiens
111 GNLY  
Affinity Capture-MS Homo sapiens
112 TNS2 23371
Affinity Capture-MS Homo sapiens
113 CLPX 10845
Affinity Capture-MS Homo sapiens
114 ACAD9 28976
Proximity Label-MS Homo sapiens
115 VWA8 23078
Proximity Label-MS Homo sapiens
116 SUGCT  
Affinity Capture-MS Homo sapiens
117 DHRS3 9249
Affinity Capture-MS Homo sapiens
118 METTL15  
Proximity Label-MS Homo sapiens
119 NFATC2  
Affinity Capture-MS Homo sapiens
120 MCUR1 63933
Proximity Label-MS Homo sapiens
121 SOX2  
Affinity Capture-MS Homo sapiens
122 APP 351
Reconstituted Complex Homo sapiens
123 BBLF2-BBLF3  
Two-hybrid
124 CLPP 8192
Proximity Label-MS Homo sapiens
125 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
126 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
127 CA6 765
Affinity Capture-MS Homo sapiens
128 TSFM 10102
Proximity Label-MS Homo sapiens
129 AUH 549
Proximity Label-MS Homo sapiens
130 TBRG4 9238
Proximity Label-MS Homo sapiens
131 MRPL11 65003
Proximity Label-MS Homo sapiens
132 FBXL6  
Affinity Capture-MS Homo sapiens
133 TP53 7157
Affinity Capture-MS Homo sapiens
134 COQ5  
Affinity Capture-MS Homo sapiens
135 COQ6 51004
Affinity Capture-MS Homo sapiens
136 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
137 NME4 4833
Affinity Capture-MS Homo sapiens
138 HDAC6 10013
Two-hybrid Homo sapiens
139 C7orf55  
Affinity Capture-MS Homo sapiens
140 PDHA1 5160
Proximity Label-MS Homo sapiens
141 DNAJA3 9093
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
142 SOX4  
Affinity Capture-MS Homo sapiens
143 SQSTM1 8878
Proximity Label-MS Homo sapiens
144 C17orf89  
Affinity Capture-MS Homo sapiens
145 COQ7  
Affinity Capture-MS Homo sapiens
146 COX8A  
Proximity Label-MS Homo sapiens
147 SHMT2 6472
Affinity Capture-RNA Homo sapiens
148 MTHFD1 4522
Co-fractionation Homo sapiens
149 C21orf33  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
150 SSBP1 6742
Proximity Label-MS Homo sapiens
151 ESR1  
Affinity Capture-MS Homo sapiens
152 Arhgap6  
Affinity Capture-MS Mus musculus
153 LONP1 9361
Proximity Label-MS Homo sapiens
154 MOV10 4343
Affinity Capture-RNA Homo sapiens
155 AARS2  
Proximity Label-MS Homo sapiens
156 TEFM  
Proximity Label-MS Homo sapiens
157 ACO2 50
Co-fractionation Homo sapiens
158 GRSF1 2926
Proximity Label-MS Homo sapiens
159 C1QBP 708
Proximity Label-MS Homo sapiens
160 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
161 C17orf80 55028
Proximity Label-MS Homo sapiens
162 METTL17  
Proximity Label-MS Homo sapiens
163 NHLH1  
Affinity Capture-MS Homo sapiens
164 CPE 1363
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which POLDIP2 is involved
No pathways found





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