Gene description for PDPR
Gene name pyruvate dehydrogenase phosphatase regulatory subunit
Gene symbol PDPR
Other names/aliases PDP3
Species Homo sapiens
 Database cross references - PDPR
ExoCarta ExoCarta_55066
Vesiclepedia VP_55066
Entrez Gene 55066
HGNC 30264
UniProt Q8NCN5  
 PDPR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
 Gene ontology annotations for PDPR
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 NAS
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 TAS
    pyruvate dehydrogenase (lipoamide) phosphatase complex GO:0045253 NAS
 Experiment description of studies that identified PDPR in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PDPR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRMT1 55621
Affinity Capture-MS Homo sapiens
2 PDHA1 5160
Proximity Label-MS Homo sapiens
3 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
4 PMPCA 23203
Proximity Label-MS Homo sapiens
5 PMPCB 9512
Proximity Label-MS Homo sapiens
6 MRPL4 51073
Affinity Capture-MS Homo sapiens
7 RARS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MRPS26 64949
Proximity Label-MS Homo sapiens
9 AUH 549
Proximity Label-MS Homo sapiens
10 TP53 7157
Affinity Capture-MS Homo sapiens
11 MRRF  
Proximity Label-MS Homo sapiens
12 TBRG4 9238
Proximity Label-MS Homo sapiens
13 MRPL11 65003
Proximity Label-MS Homo sapiens
14 MTERF3  
Proximity Label-MS Homo sapiens
15 MTIF2 4528
Proximity Label-MS Homo sapiens
16 DDX58 23586
Affinity Capture-RNA Homo sapiens
17 ACSM5 54988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ARHGEF26 26084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PCMT1 5110
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TACO1  
Proximity Label-MS Homo sapiens
22 MTG1  
Proximity Label-MS Homo sapiens
23 RAD51D  
Affinity Capture-MS Homo sapiens
24 RMND1 55005
Proximity Label-MS Homo sapiens
25 MTG2  
Proximity Label-MS Homo sapiens
26 C6orf203  
Proximity Label-MS Homo sapiens
27 COX4I1 1327
Proximity Label-MS Homo sapiens
28 CUL3 8452
Affinity Capture-MS Homo sapiens
29 ATP5F1 515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MRPL37 51253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 FASTKD5  
Proximity Label-MS Homo sapiens
32 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 BPNT1 10380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ICT1 3396
Proximity Label-MS Homo sapiens
35 PARK2  
Affinity Capture-MS Homo sapiens
36 SHMT2 6472
Affinity Capture-RNA Homo sapiens
37 C21orf33  
Proximity Label-MS Homo sapiens
38 SLC25A41  
Affinity Capture-MS Homo sapiens
39 GFM2 84340
Proximity Label-MS Homo sapiens
40 SSBP1 6742
Proximity Label-MS Homo sapiens
41 CCDC90B  
Proximity Label-MS Homo sapiens
42 NXF1 10482
Affinity Capture-RNA Homo sapiens
43 TUFM 7284
Proximity Label-MS Homo sapiens
44 LRPPRC 10128
Proximity Label-MS Homo sapiens
45 GATC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 OTC 5009
Proximity Label-MS Homo sapiens
47 HSCB 150274
Proximity Label-MS Homo sapiens
48 TSC22D4 81628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 C1orf220  
Affinity Capture-MS Homo sapiens
50 MCUR1 63933
Proximity Label-MS Homo sapiens
51 CRYZ 1429
Proximity Label-MS Homo sapiens
52 FASTKD2  
Proximity Label-MS Homo sapiens
53 COX8A  
Proximity Label-MS Homo sapiens
54 NTRK1 4914
Affinity Capture-MS Homo sapiens
55 AARS2  
Proximity Label-MS Homo sapiens
56 SDHB 6390
Affinity Capture-MS Homo sapiens
57 TSFM 10102
Proximity Label-MS Homo sapiens
58 RAB40C 57799
Affinity Capture-MS Homo sapiens
59 RPUSD3  
Proximity Label-MS Homo sapiens
60 NIT1 4817
Affinity Capture-MS Homo sapiens
61 MOV10 4343
Affinity Capture-RNA Homo sapiens
62 ACAD9 28976
Proximity Label-MS Homo sapiens
63 HINT2 84681
Proximity Label-MS Homo sapiens
64 PPA2 27068
Affinity Capture-MS Homo sapiens
65 ENO1 2023
Affinity Capture-RNA Homo sapiens
66 POU5F1  
Affinity Capture-MS Homo sapiens
67 TRUB2  
Proximity Label-MS Homo sapiens
68 METTL17  
Proximity Label-MS Homo sapiens
69 MDH2 4191
Proximity Label-MS Homo sapiens
70 MTRF1L  
Proximity Label-MS Homo sapiens
71 NANOG  
Affinity Capture-MS Homo sapiens
72 PDP1 54704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 METTL15  
Proximity Label-MS Homo sapiens
74 SURF1  
Proximity Label-MS Homo sapiens
75 PFDN5 5204
Affinity Capture-MS Homo sapiens
76 PSG8  
Affinity Capture-MS Homo sapiens
77 EXD2  
Proximity Label-MS Homo sapiens
78 MTRF1  
Proximity Label-MS Homo sapiens
79 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 AIFM1 9131
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here