Gene description for DECR1
Gene name 2,4-dienoyl CoA reductase 1, mitochondrial
Gene symbol DECR1
Other names/aliases DECR
NADPH
SDR18C1
Species Homo sapiens
 Database cross references - DECR1
ExoCarta ExoCarta_1666
Entrez Gene 1666
HGNC 2753
MIM 222745
UniProt Q16698  
 DECR1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Thymus 23844026    
 Gene ontology annotations for DECR1
Molecular Function
    oxidoreductase activity, acting on NAD(P)H GO:0016651 TAS
    2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670 IDA
    NADPH binding GO:0070402 IDA
Biological Process
    cellular lipid metabolic process GO:0044255 TAS
    fatty acid beta-oxidation GO:0006635 TAS
    small molecule metabolic process GO:0044281 TAS
    protein homotetramerization GO:0051289 IDA
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    nucleoplasm GO:0005654 IDA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 NAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified DECR1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DECR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DECR1 is involved
PathwayEvidenceSource
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids TAS Reactome





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