Gene description for FAHD1
Gene name fumarylacetoacetate hydrolase domain containing 1
Gene symbol FAHD1
Other names/aliases C16orf36
YISKL
Species Homo sapiens
 Database cross references - FAHD1
ExoCarta ExoCarta_81889
Vesiclepedia VP_81889
Entrez Gene 81889
HGNC 14169
MIM 616320
UniProt Q6P587  
 FAHD1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FAHD1
Molecular Function
    protein binding GO:0005515 IPI
    oxaloacetate decarboxylase activity GO:0008948 IDA
    acetylpyruvate hydrolase activity GO:0018773 IBA
    acetylpyruvate hydrolase activity GO:0018773 IDA
    fumarylpyruvate hydrolase activity GO:0034545 IDA
    metal ion binding GO:0046872 IEA
    acylpyruvate hydrolase activity GO:0047621 IEA
    oxaloacetate tautomerase activity GO:0050163 IDA
Biological Process
    pyruvate metabolic process GO:0006090 IEA
    oxaloacetate metabolic process GO:0006107 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified FAHD1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FAHD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LDHA 3939
Co-fractionation Homo sapiens
2 MRPL48  
Affinity Capture-MS Homo sapiens
3 SPRTN  
Affinity Capture-MS Homo sapiens
4 BCKDK 10295
Affinity Capture-MS Homo sapiens
5 MACROD1 28992
Affinity Capture-MS Homo sapiens
6 PAXIP1  
Two-hybrid Homo sapiens
7 CPS1 1373
Affinity Capture-MS Homo sapiens
8 GUK1 2987
Affinity Capture-MS Homo sapiens
9 LDHB 3945
Co-fractionation Homo sapiens
10 GTPBP10  
Affinity Capture-MS Homo sapiens
11 MME 4311
Affinity Capture-MS Homo sapiens
12 EXD2  
Affinity Capture-MS Homo sapiens
13 RSAD1  
Affinity Capture-MS Homo sapiens
14 TRUB2  
Affinity Capture-MS Homo sapiens
15 MTG2  
Affinity Capture-MS Homo sapiens
16 MRPL24  
Affinity Capture-MS Homo sapiens
17 CDK5RAP1  
Affinity Capture-MS Homo sapiens
18 MRPL27 51264
Affinity Capture-MS Homo sapiens
19 BPNT1 10380
Co-fractionation Homo sapiens
20 GATB  
Affinity Capture-MS Homo sapiens
21 PIR 8544
Co-fractionation Homo sapiens
22 CFL1 1072
Co-fractionation Homo sapiens
23 GFM2 84340
Affinity Capture-MS Homo sapiens
24 CAB39 51719
Co-fractionation Homo sapiens
25 NDUFB9 4715
Affinity Capture-MS Homo sapiens
26 MRPL20 55052
Affinity Capture-MS Homo sapiens
27 DAZAP1 26528
Co-fractionation Homo sapiens
28 PC 5091
Affinity Capture-MS Homo sapiens
29 PTRHD1 391356
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
30 D2HGDH 728294
Affinity Capture-MS Homo sapiens
31 HARS2 23438
Affinity Capture-MS Homo sapiens
32 MRPS5 64969
Affinity Capture-MS Homo sapiens
33 YARS2  
Affinity Capture-MS Homo sapiens
34 AK3 50808
Co-fractionation Homo sapiens
35 INHA  
Affinity Capture-MS Homo sapiens
36 FTSJ2 29960
Affinity Capture-MS Homo sapiens
37 MRPL57  
Affinity Capture-MS Homo sapiens
38 NSUN4  
Affinity Capture-MS Homo sapiens
39 POLRMT 5442
Affinity Capture-MS Homo sapiens
40 PTCD1 26024
Affinity Capture-MS Homo sapiens
41 TRIT1  
Affinity Capture-MS Homo sapiens
42 ERAL1  
Affinity Capture-MS Homo sapiens
43 GUSB 2990
Co-fractionation Homo sapiens
44 NDUFAF1  
Affinity Capture-MS Homo sapiens
45 IVD 3712
Affinity Capture-MS Homo sapiens
46 CPT2 1376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ACSF2 80221
Affinity Capture-MS Homo sapiens
48 PREPL 9581
Affinity Capture-MS Homo sapiens
49 NDUFA6  
Affinity Capture-MS Homo sapiens
50 ADCK4 79934
Affinity Capture-MS Homo sapiens
51 MRPL47 57129
Affinity Capture-MS Homo sapiens
52 MTERF3  
Affinity Capture-MS Homo sapiens
53 GDA 9615
Co-fractionation Homo sapiens
54 ABAT  
Co-fractionation Homo sapiens
55 MDH2 4191
Co-fractionation Homo sapiens
56 MRPS30 10884
Affinity Capture-MS Homo sapiens
57 MRPL13  
Affinity Capture-MS Homo sapiens
58 FARS2 10667
Affinity Capture-MS Homo sapiens
59 COASY 80347
Affinity Capture-MS Homo sapiens
60 FASTKD5  
Affinity Capture-MS Homo sapiens
61 MRPL45 84311
Affinity Capture-MS Homo sapiens
62 MTO1  
Affinity Capture-MS Homo sapiens
63 MGME1  
Affinity Capture-MS Homo sapiens
64 ATPAF1  
Affinity Capture-MS Homo sapiens
65 OR10H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
67 PCCA 5095
Affinity Capture-MS Homo sapiens
68 ABHD11 83451
Affinity Capture-MS Homo sapiens
69 ALDH6A1 4329
Affinity Capture-MS Homo sapiens
70 EXOSC4 54512
Two-hybrid Homo sapiens
71 TARS2 80222
Affinity Capture-MS Homo sapiens
72 TBRG4 9238
Affinity Capture-MS Homo sapiens
73 CYP24A1  
Affinity Capture-MS Homo sapiens
74 KIAA0391  
Affinity Capture-MS Homo sapiens
75 MRPL3  
Affinity Capture-MS Homo sapiens
76 NARS2  
Affinity Capture-MS Homo sapiens
77 DBT 1629
Affinity Capture-MS Homo sapiens
78 IDH3G 3421
Affinity Capture-MS Homo sapiens
79 C14orf159 80017
Affinity Capture-MS Homo sapiens
80 PROSC 11212
Affinity Capture-MS Homo sapiens
81 MRPL2 51069
Affinity Capture-MS Homo sapiens
82 MRPL41 64975
Affinity Capture-MS Homo sapiens
83 TXN2 25828
Co-fractionation Homo sapiens
84 CAT 847
Co-fractionation Homo sapiens
85 MRPL40 64976
Affinity Capture-MS Homo sapiens
86 EARS2  
Affinity Capture-MS Homo sapiens
87 AK2 204
Co-fractionation Homo sapiens
88 GIMAP8 155038
Co-fractionation Homo sapiens
89 MTIF2 4528
Affinity Capture-MS Homo sapiens
90 PNPT1 87178
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 MRPL35  
Affinity Capture-MS Homo sapiens
92 CHDH 55349
Affinity Capture-MS Homo sapiens
93 ANXA1 301
Co-fractionation Homo sapiens
94 MRPL9 65005
Affinity Capture-MS Homo sapiens
95 GOT1 2805
Co-fractionation Homo sapiens
96 MRPL16  
Affinity Capture-MS Homo sapiens
97 ACAD10  
Affinity Capture-MS Homo sapiens
98 MRPL42  
Affinity Capture-MS Homo sapiens
99 NANS 54187
Co-fractionation Homo sapiens
100 THNSL1 79896
Affinity Capture-MS Homo sapiens
101 GADD45GIP1  
Affinity Capture-MS Homo sapiens
102 SORD 6652
Co-fractionation Homo sapiens
103 DHTKD1 55526
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 MRPL15 29088
Affinity Capture-MS Homo sapiens
105 CECR5 27440
Affinity Capture-MS Homo sapiens
106 FPGS 2356
Affinity Capture-MS Homo sapiens
107 MUT 4594
Affinity Capture-MS Homo sapiens
108 PCBP1 5093
Co-fractionation Homo sapiens
109 RPA3 6119
Proximity Label-MS Homo sapiens
110 PPAP2A 8611
Two-hybrid Homo sapiens
111 COL10A1  
Affinity Capture-MS Homo sapiens
112 VWA8 23078
Affinity Capture-MS Homo sapiens
113 NDUFA10 4705
Affinity Capture-MS Homo sapiens
114 HSPD1 3329
Affinity Capture-MS Homo sapiens
115 MTPAP 55149
Affinity Capture-MS Homo sapiens
116 PUS1 80324
Affinity Capture-MS Homo sapiens
117 METTL15  
Affinity Capture-MS Homo sapiens
118 BRD3 8019
Affinity Capture-MS Homo sapiens
119 SARDH 1757
Affinity Capture-MS Homo sapiens
120 MRPL18 29074
Affinity Capture-MS Homo sapiens
121 MTHFD1L 25902
Affinity Capture-MS Homo sapiens
122 COA4  
Co-fractionation Homo sapiens
123 SUMF2 25870
Co-fractionation Homo sapiens
124 GLS 2744
Affinity Capture-MS Homo sapiens
125 ARL2 402
Affinity Capture-MS Homo sapiens
126 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
127 ALDOC 230
Co-fractionation Homo sapiens
128 TSFM 10102
Affinity Capture-MS Homo sapiens
129 CLPX 10845
Affinity Capture-MS Homo sapiens
130 ALDH4A1 8659
Affinity Capture-MS Homo sapiens
131 SDR39U1  
Affinity Capture-MS Homo sapiens
132 COQ6 51004
Affinity Capture-MS Homo sapiens
133 ICT1 3396
Affinity Capture-MS Homo sapiens
134 LARS2 23395
Affinity Capture-MS Homo sapiens
135 ISOC2  
Co-fractionation Homo sapiens
136 BCKDHA 593
Affinity Capture-MS Homo sapiens
137 FSD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 CLUH 23277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 UBR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 TMLHE 55217
Affinity Capture-MS Homo sapiens
141 SELO 83642
Affinity Capture-MS Homo sapiens
142 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 GUF1  
Affinity Capture-MS Homo sapiens
144 NUDT9 53343
Affinity Capture-MS Homo sapiens
145 IDH2 3418
Co-fractionation Homo sapiens
146 NDUFA2 4695
Affinity Capture-MS Homo sapiens
147 AARS2  
Affinity Capture-MS Homo sapiens
148 ALAS1  
Affinity Capture-MS Homo sapiens
149 TRMT5  
Affinity Capture-MS Homo sapiens
150 MRPL46  
Affinity Capture-MS Homo sapiens
151 FECH 2235
Affinity Capture-MS Homo sapiens
152 MIPEP  
Affinity Capture-MS Homo sapiens
153 BNIP2  
Two-hybrid Homo sapiens
154 DHRS4 10901
Affinity Capture-MS Homo sapiens
155 ACSF3 197322
Affinity Capture-MS Homo sapiens
156 SERBP1 26135
Affinity Capture-MS Homo sapiens
157 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
158 QRSL1  
Affinity Capture-MS Homo sapiens
159 MRPL55  
Affinity Capture-MS Homo sapiens
160 METTL17  
Affinity Capture-MS Homo sapiens
161 POLG  
Affinity Capture-MS Homo sapiens
162 MRPL28 10573
Affinity Capture-MS Homo sapiens
163 AK1 203
Co-fractionation Homo sapiens
164 MRPS18A  
Affinity Capture-MS Homo sapiens
165 DARS2 55157
Affinity Capture-MS Homo sapiens
166 FASTKD2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAHD1 is involved
PathwayEvidenceSource
Aerobic respiration and respiratory electron transport TAS Reactome
Metabolism TAS Reactome
Pyruvate metabolism TAS Reactome





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