Gene description for MRPL40
Gene name mitochondrial ribosomal protein L40
Gene symbol MRPL40
Other names/aliases MRP-L22
MRPL22
NLVCF
URIM
Species Homo sapiens
 Database cross references - MRPL40
ExoCarta ExoCarta_64976
Vesiclepedia VP_64976
Entrez Gene 64976
HGNC 14491
MIM 605089
UniProt Q9NQ50  
 MRPL40 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MRPL40
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    anatomical structure morphogenesis GO:0009653 TAS
    mitochondrial translation GO:0032543 NAS
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial ribosome GO:0005761 IBA
    mitochondrial ribosome GO:0005761 ISS
    mitochondrial large ribosomal subunit GO:0005762 IDA
    mitochondrial large ribosomal subunit GO:0005762 NAS
 Experiment description of studies that identified MRPL40 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MRPL40
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMA6 5687
Cross-Linking-MS (XL-MS) Homo sapiens
2 HNRNPC 3183
Co-fractionation Homo sapiens
3 H1FNT  
Affinity Capture-MS Homo sapiens
4 RBMS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 MRPL30  
Affinity Capture-MS Homo sapiens
6 RPL13A 23521
Affinity Capture-MS Homo sapiens
7 TRUB2  
Proximity Label-MS Homo sapiens
8 MTG2  
Proximity Label-MS Homo sapiens
9 NGRN  
Proximity Label-MS Homo sapiens
10 RPL10 6134
Affinity Capture-MS Homo sapiens
11 CHCHD1  
Proximity Label-MS Homo sapiens
12 MRPL37 51253
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MRPL27 51264
Affinity Capture-MS Homo sapiens
14 MRPL50 54534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
15 HNRNPR 10236
Co-fractionation Homo sapiens
16 RPUSD4 84881
Proximity Label-MS Homo sapiens
17 MTRF1  
Proximity Label-MS Homo sapiens
18 LRPPRC 10128
Proximity Label-MS Homo sapiens
19 TFAM 7019
Proximity Label-MS Homo sapiens
20 PMPCA 23203
Proximity Label-MS Homo sapiens
21 SDHB 6390
Co-fractionation Homo sapiens
22 MRPL23 6150
Affinity Capture-MS Homo sapiens
23 EIF3B 8662
Co-fractionation Homo sapiens
24 PRC1 9055
Affinity Capture-MS Homo sapiens
25 HINT2 84681
Proximity Label-MS Homo sapiens
26 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MRPS26 64949
Proximity Label-MS Homo sapiens
28 KRT31 3881
Two-hybrid Homo sapiens
29 EXD2  
Proximity Label-MS Homo sapiens
30 MRPL39 54148
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CEP57  
Affinity Capture-MS Homo sapiens
32 MECP2 4204
Affinity Capture-MS Homo sapiens
33 TFCP2 7024
Two-hybrid Homo sapiens
34 PMPCB 9512
Proximity Label-MS Homo sapiens
35 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 VWA8 23078
Proximity Label-MS Homo sapiens
37 MRPL47 57129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 RPL19 6143
Affinity Capture-MS Homo sapiens
39 MTERF3  
Proximity Label-MS Homo sapiens
40 LIN28A  
Affinity Capture-MS Homo sapiens
41 MDH2 4191
Proximity Label-MS Homo sapiens
42 STOML2 30968
Co-fractionation Homo sapiens
43 MRPS30 10884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 MRPL13  
Affinity Capture-MS Homo sapiens
45 MRPL32 64983
Co-fractionation Homo sapiens
46 MPV17 4358
Co-fractionation Homo sapiens
47 SCFD1 23256
Co-fractionation Homo sapiens
48 C6orf203  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
49 FASTKD5  
Proximity Label-MS Homo sapiens
50 MALSU1  
Affinity Capture-MS Homo sapiens
51 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
52 SRSF3 6428
Affinity Capture-MS Homo sapiens
53 YBX2 51087
Affinity Capture-MS Homo sapiens
54 HADHA 3030
Co-fractionation Homo sapiens
55 TUFM 7284
Proximity Label-MS Homo sapiens
56 HSCB 150274
Proximity Label-MS Homo sapiens
57 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
58 RPL35 11224
Affinity Capture-MS Homo sapiens
59 CYSRT1 375791
Two-hybrid Homo sapiens
60 MRPL18 29074
Affinity Capture-MS Homo sapiens
61 FGF8  
Affinity Capture-MS Homo sapiens
62 TBRG4 9238
Proximity Label-MS Homo sapiens
63 ZMPSTE24 10269
Co-fractionation Homo sapiens
64 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
65 RPL27A 6157
Affinity Capture-MS Homo sapiens
66 RPS6 6194
Affinity Capture-MS Homo sapiens
67 MRPL11 65003
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
68 MTRF1L  
Proximity Label-MS Homo sapiens
69 TMEM70  
Proximity Label-MS Homo sapiens
70 MRPL2 51069
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
71 MRPL41 64975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 ATP6V1D 51382
Co-fractionation Homo sapiens
73 NOTCH2NL 388677
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
74 MRPL14 64928
Co-fractionation Homo sapiens
75 STK3 6788
Affinity Capture-MS Homo sapiens
76 MRPL51 51258
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
77 MRPL21 219927
Co-fractionation Homo sapiens
78 MRRF  
Proximity Label-MS Homo sapiens
79 MRPS12  
Proximity Label-MS Homo sapiens
80 AURKAIP1  
Affinity Capture-MS Homo sapiens
81 MTIF2 4528
Proximity Label-MS Homo sapiens
82 MRPL24  
Co-fractionation Homo sapiens
83 MRPL35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 RPL23AP32 56969
Affinity Capture-MS Homo sapiens
85 MTIF3  
Proximity Label-MS Homo sapiens
86 SRSF4 6429
Affinity Capture-MS Homo sapiens
87 PLRG1 5356
Co-fractionation Homo sapiens
88 MRPL9 65005
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
89 MRPL16  
Co-fractionation Homo sapiens
90 RPL37 6167
Affinity Capture-MS Homo sapiens
91 ATL3 25923
Co-fractionation Homo sapiens
92 ATP5F1 515
Co-fractionation Homo sapiens
93 FAHD1 81889
Affinity Capture-MS Homo sapiens
94 GADD45GIP1  
Affinity Capture-MS Homo sapiens
95 KRTAP10-3  
Two-hybrid Homo sapiens
96 BTRC 8945
Affinity Capture-MS Homo sapiens
97 MRPL15 29088
Co-fractionation Homo sapiens
98 MRPL1  
Affinity Capture-MS Homo sapiens
99 MYCN  
Affinity Capture-MS Homo sapiens
100 MRPL52  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
101 TACO1  
Proximity Label-MS Homo sapiens
102 MYC  
Affinity Capture-MS Homo sapiens
103 DLST 1743
Co-fractionation Homo sapiens
104 TRIM27  
Two-hybrid Homo sapiens
105 ACAD9 28976
Proximity Label-MS Homo sapiens
106 MRPL38  
Co-fractionation Homo sapiens
107 TSR1 55720
Co-fractionation Homo sapiens
108 METTL15  
Proximity Label-MS Homo sapiens
109 UPF2 26019
Two-hybrid Homo sapiens
110 RBMS2 5939
Affinity Capture-MS Homo sapiens
111 C12orf65  
Proximity Label-MS Homo sapiens
112 RPL13 6137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 YBX1 4904
Affinity Capture-MS Homo sapiens
114 DNAJC28  
Proximity Label-MS Homo sapiens
115 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
116 MRPL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
117 PHB2 11331
Co-fractionation Homo sapiens
118 TSFM 10102
Proximity Label-MS Homo sapiens
119 AUH 549
Proximity Label-MS Homo sapiens
120 ILF3 3609
Co-fractionation Homo sapiens
121 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
122 SOX15  
Co-fractionation Homo sapiens
123 MRPL53  
Affinity Capture-MS Homo sapiens
124 MRPL43 84545
Co-fractionation Homo sapiens
125 NBPF19  
Two-hybrid Homo sapiens
126 MRPL10 124995
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 USP44  
Affinity Capture-MS Homo sapiens
128 HSPB1 3315
Two-hybrid Homo sapiens
129 CLUH 23277
Co-fractionation Homo sapiens
130 COX8A  
Proximity Label-MS Homo sapiens
131 C21orf33  
Proximity Label-MS Homo sapiens
132 SSBP1 6742
Proximity Label-MS Homo sapiens
133 GFM1 85476
Proximity Label-MS Homo sapiens
134 AARS2  
Proximity Label-MS Homo sapiens
135 MRPL46  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 ATP1A1 476
Co-fractionation Homo sapiens
137 MRPL19 9801
Co-fractionation Homo sapiens
138 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 KRTAP3-1  
Two-hybrid Homo sapiens
140 GRSF1 2926
Proximity Label-MS Homo sapiens
141 C1QBP 708
Proximity Label-MS Homo sapiens
142 KRAS 3845
Negative Genetic Homo sapiens
143 HNRNPU 3192
Affinity Capture-MS Homo sapiens
144 TAP1 6890
Co-fractionation Homo sapiens
145 MRPL55  
Co-fractionation Homo sapiens
146 RPL36AL 6166
Affinity Capture-MS Homo sapiens
147 METTL17  
Proximity Label-MS Homo sapiens
148 MRPL28 10573
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 MRPS18A  
Affinity Capture-MS Homo sapiens
150 MRPS9 64965
Co-fractionation Homo sapiens
151 RPL17 6139
Affinity Capture-MS Homo sapiens
152 CDC5L 988
Co-fractionation Homo sapiens
View the network image/svg+xml



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