Gene description for AK3
Gene name adenylate kinase 3
Gene symbol AK3
Other names/aliases AK3L1
AK6
AKL3L
AKL3L1
FIX
Species Homo sapiens
 Database cross references - AK3
ExoCarta ExoCarta_50808
Entrez Gene 50808
HGNC 17376
MIM 609290
UniProt Q9UIJ7  
 AK3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for AK3
Molecular Function
    protein binding GO:0005515 IPI
    nucleoside triphosphate adenylate kinase activity GO:0046899 IDA
    adenylate kinase activity GO:0004017 IDA
    ATP binding GO:0005524 IEA
    GTP binding GO:0005525 IEA
Biological Process
    phosphorylation GO:0016310 IEA
    ITP metabolic process GO:0046041 IDA
    blood coagulation GO:0007596 TAS
    AMP metabolic process GO:0046033 IDA
    ADP biosynthetic process GO:0006172 IEA
    GTP metabolic process GO:0046039 IDA
    UTP metabolic process GO:0046051 IDA
Subcellular Localization
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified AK3 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for AK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AK3 is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production TAS Reactome





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