Gene description for NDUFS2
Gene name NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Gene symbol NDUFS2
Other names/aliases CI-49
Species Homo sapiens
 Database cross references - NDUFS2
ExoCarta ExoCarta_4720
Entrez Gene 4720
HGNC 7708
MIM 602985
UniProt O75306  
 NDUFS2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NDUFS2
Molecular Function
    electron carrier activity GO:0009055 NAS
    metal ion binding GO:0046872 IEA
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
    NADH dehydrogenase activity GO:0003954 IMP
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    4 iron, 4 sulfur cluster binding GO:0051539 IEA
    quinone binding GO:0048038 IEA
    NAD binding GO:0051287 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    cellular metabolic process GO:0044237 TAS
    response to oxidative stress GO:0006979 IDA
    respiratory electron transport chain GO:0022904 TAS
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrion GO:0005739 NAS
    mitochondrial respiratory chain complex I GO:0005747 NAS
 Experiment description of studies that identified NDUFS2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NDUFS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NDUFS2 is involved
PathwayEvidenceSource
Respiratory electron transport TAS Reactome





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