Gene description for COX15
Gene name cytochrome c oxidase assembly homolog 15 (yeast)
Gene symbol COX15
Other names/aliases CEMCOX2
Species Homo sapiens
 Database cross references - COX15
ExoCarta ExoCarta_1355
Vesiclepedia VP_1355
Entrez Gene 1355
HGNC 2263
MIM 603646
UniProt Q7KZN9  
 COX15 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COX15
Molecular Function
    protein binding GO:0005515 IPI
    oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 IMP
    oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 TAS
    oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor GO:0016653 IBA
    heme binding GO:0020037 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    heme biosynthetic process GO:0006783 TAS
    heme A biosynthetic process GO:0006784 IBA
    heme A biosynthetic process GO:0006784 IEA
    heme A biosynthetic process GO:0006784 IGI
    cytochrome complex assembly GO:0017004 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 TAS
    cytochrome complex GO:0070069 IDA
    respiratory chain complex GO:0098803 TAS
 Experiment description of studies that identified COX15 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COX15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPY19L1 23333
Affinity Capture-MS Homo sapiens
2 TIMM44 10469
Proximity Label-MS Homo sapiens
3 RALY 22913
Affinity Capture-MS Homo sapiens
4 COX5A 9377
Proximity Label-MS Homo sapiens
5 RIT1 6016
Negative Genetic Homo sapiens
6 AFG3L2 10939
Proximity Label-MS Homo sapiens
7 PYCR2 29920
Proximity Label-MS Homo sapiens
8 RPL26L1 51121
Affinity Capture-MS Homo sapiens
9 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
10 SLC1A5 6510
Affinity Capture-MS Homo sapiens
11 NOP58 51602
Affinity Capture-MS Homo sapiens
12 NOLC1 9221
Affinity Capture-MS Homo sapiens
13 ETFA 2108
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
14 DNAJA3 9093
Proximity Label-MS Homo sapiens
15 ATAD3A 55210
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
16 NDUFS1 4719
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
17 RPL30 6156
Affinity Capture-MS Homo sapiens
18 PSMA4 5685
Affinity Capture-MS Homo sapiens
19 LDHA 3939
Affinity Capture-MS Homo sapiens
20 DHX30 22907
Affinity Capture-MS Homo sapiens
21 MRPS10 55173
Proximity Label-MS Homo sapiens
22 HIST1H2BG 8339
Affinity Capture-MS Homo sapiens
23 BOLA2B 654483
Affinity Capture-MS Homo sapiens
24 DBN1 1627
Affinity Capture-MS Homo sapiens
25 NOP56 10528
Affinity Capture-MS Homo sapiens
26 SLC2A1 6513
Affinity Capture-MS Homo sapiens
27 TOP1 7150
Affinity Capture-MS Homo sapiens
28 MRPL37 51253
Proximity Label-MS Homo sapiens
29 MRPL27 51264
Proximity Label-MS Homo sapiens
30 TOX3  
Proximity Label-MS Homo sapiens
31 NDUFS7 374291
Proximity Label-MS Homo sapiens
32 PPIA 5478
Affinity Capture-MS Homo sapiens
33 PTPMT1 114971
Proximity Label-MS Homo sapiens
34 NDUFA4 4697
Affinity Capture-MS Homo sapiens
35 ELAVL1 1994
Affinity Capture-MS Homo sapiens
36 MRPL49 740
Affinity Capture-MS Homo sapiens
37 MRPS27 23107
Proximity Label-MS Homo sapiens
38 NDUFS2 4720
Proximity Label-MS Homo sapiens
39 MRPS24 64951
Proximity Label-MS Homo sapiens
40 CCDC90B  
Proximity Label-MS Homo sapiens
41 PDE2A  
Affinity Capture-MS Homo sapiens
42 ILF2 3608
Affinity Capture-MS Homo sapiens
43 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
44 LRPPRC 10128
Proximity Label-MS Homo sapiens
45 SAFB 6294
Affinity Capture-MS Homo sapiens
46 CAPZB 832
Affinity Capture-MS Homo sapiens
47 NEFL 4747
Proximity Label-MS Homo sapiens
48 TOP2A 7153
Affinity Capture-MS Homo sapiens
49 RPL10A 4736
Affinity Capture-MS Homo sapiens
50 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
51 TIMMDC1  
Proximity Label-MS Homo sapiens
52 RNPS1 10921
Affinity Capture-MS Homo sapiens
53 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
54 OGDH 4967
Proximity Label-MS Homo sapiens
55 PRDX3 10935
Affinity Capture-MS Homo sapiens
56 RBMXL2  
Affinity Capture-MS Homo sapiens
57 IARS2 55699
Proximity Label-MS Homo sapiens
58 COQ9  
Affinity Capture-MS Homo sapiens
59 H1FX 8971
Affinity Capture-MS Homo sapiens
60 DNAJC11 55735
Proximity Label-MS Homo sapiens
61 SHMT2 6472
Proximity Label-MS Homo sapiens
62 RRP12 23223
Affinity Capture-MS Homo sapiens
63 H2AFV 94239
Affinity Capture-MS Homo sapiens
64 MRPS5 64969
Proximity Label-MS Homo sapiens
65 TFRC 7037
Affinity Capture-MS Homo sapiens
66 MRPS23 51649
Proximity Label-MS Homo sapiens
67 NDUFA5 4698
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
68 MRPL12 6182
Proximity Label-MS Homo sapiens
69 QPCTL 54814
Affinity Capture-MS Homo sapiens
70 TOMM7 54543
Co-fractionation Homo sapiens
71 TRAP1 10131
Affinity Capture-MS Homo sapiens
72 RHOA 387
Affinity Capture-MS Homo sapiens
73 MRPS26 64949
Proximity Label-MS Homo sapiens
74 SURF1  
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
75 ATP2A3 489
Affinity Capture-MS Homo sapiens
76 LAMTOR3 8649
Co-fractionation Homo sapiens
77 DYNLL1 8655
Affinity Capture-MS Homo sapiens
78 SERPINH1 871
Affinity Capture-MS Homo sapiens
79 NDUFA8 4702
Proximity Label-MS Homo sapiens
80 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
81 MRPL39 54148
Proximity Label-MS Homo sapiens
82 CHMP4A 29082
Affinity Capture-MS Homo sapiens
83 NDUFV1 4723
Proximity Label-MS Homo sapiens
84 MRPS21  
Affinity Capture-MS Homo sapiens
85 FBL 2091
Affinity Capture-MS Homo sapiens
86 CHTOP  
Affinity Capture-MS Homo sapiens
87 ATP5H 10476
Affinity Capture-MS Homo sapiens
88 NHP2 55651
Affinity Capture-MS Homo sapiens
89 H2AFY2 55506
Affinity Capture-MS Homo sapiens
90 CPT2 1376
Proximity Label-MS Homo sapiens
91 MRPL4 51073
Proximity Label-MS Homo sapiens
92 DLAT 1737
Proximity Label-MS Homo sapiens
93 ACAD9 28976
Proximity Label-MS Homo sapiens
94 PABPC4 8761
Affinity Capture-MS Homo sapiens
95 SLC25A3 5250
Affinity Capture-MS Homo sapiens
96 DCD 117159
Affinity Capture-MS Homo sapiens
97 PARL  
Proximity Label-MS Homo sapiens
98 PRDX4 10549
Affinity Capture-MS Homo sapiens
99 STOML2 30968
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
100 APOO 79135
Proximity Label-MS Homo sapiens
101 PPM1B 5495
Affinity Capture-MS Homo sapiens
102 RPL27 6155
Affinity Capture-MS Homo sapiens
103 KCNK1  
Affinity Capture-MS Homo sapiens
104 DDOST 1650
Affinity Capture-MS Homo sapiens
105 IRS4 8471
Affinity Capture-MS Homo sapiens
106 LMNB1 4001
Affinity Capture-MS Homo sapiens
107 GUF1  
Proximity Label-MS Homo sapiens
108 NDUFS4 4724
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
109 SAMM50 25813
Proximity Label-MS Homo sapiens
110 DDX21 9188
Affinity Capture-MS Homo sapiens
111 EMD 2010
Affinity Capture-MS Homo sapiens
112 ADAR 103
Affinity Capture-MS Homo sapiens
113 TOP2B 7155
Affinity Capture-MS Homo sapiens
114 FAM162A 26355
Proximity Label-MS Homo sapiens
115 MRPS34 65993
Proximity Label-MS Homo sapiens
116 CENPV 201161
Affinity Capture-MS Homo sapiens
117 CHCHD3 54927
Proximity Label-MS Homo sapiens
118 HSP90B1 7184
Affinity Capture-MS Homo sapiens
119 GNAI1 2770
Affinity Capture-MS Homo sapiens
120 BLM 641
Affinity Capture-MS Homo sapiens
121 ACIN1 22985
Affinity Capture-MS Homo sapiens
122 PAM16  
Proximity Label-MS Homo sapiens
123 MRPS28  
Proximity Label-MS Homo sapiens
124 MRPS36 92259
Proximity Label-MS Homo sapiens
125 DIABLO 56616
Proximity Label-MS Homo sapiens
126 COA7  
Proximity Label-MS Homo sapiens
127 PTCD3 55037
Proximity Label-MS Homo sapiens
128 SUPT16H 11198
Affinity Capture-MS Homo sapiens
129 NDUFS8 4728
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
130 EEF1E1 9521
Affinity Capture-MS Homo sapiens
131 CHMP4B 128866
Affinity Capture-MS Homo sapiens
132 CLCC1 23155
Affinity Capture-MS Homo sapiens
133 YWHAE 7531
Affinity Capture-MS Homo sapiens
134 FASN 2194
Affinity Capture-MS Homo sapiens
135 MRS2  
Proximity Label-MS Homo sapiens
136 MRPS6  
Proximity Label-MS Homo sapiens
137 PABPC1 26986
Affinity Capture-MS Homo sapiens
138 GPR182  
Affinity Capture-MS Homo sapiens
139 OPA1 4976
Proximity Label-MS Homo sapiens
140 RPL36 25873
Affinity Capture-MS Homo sapiens
141 BANF1 8815
Affinity Capture-MS Homo sapiens
142 CYC1 1537
Co-fractionation Homo sapiens
143 RPN1 6184
Affinity Capture-MS Homo sapiens
144 GANAB 23193
Affinity Capture-MS Homo sapiens
145 CHCHD6 84303
Proximity Label-MS Homo sapiens
146 MYH11 4629
Affinity Capture-MS Homo sapiens
147 HIST1H2BF 8343
Affinity Capture-MS Homo sapiens
148 IARS 3376
Affinity Capture-MS Homo sapiens
149 MRPL50 54534
Affinity Capture-MS Homo sapiens
150 DNAJC30  
Proximity Label-MS Homo sapiens
151 FLOT2 2319
Affinity Capture-MS Homo sapiens
152 NDUFV3 4731
Proximity Label-MS Homo sapiens
153 VDAC2 7417
Affinity Capture-MS Homo sapiens
154 NDUFAF3 25915
Proximity Label-MS Homo sapiens
155 SRPK1 6732
Affinity Capture-MS Homo sapiens
156 PEX19 5824
Proximity Label-MS Homo sapiens
157 SLC25A5 292
Affinity Capture-MS Homo sapiens
158 COX4I1 1327
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
159 MRPL41 64975
Proximity Label-MS Homo sapiens
160 SSR4 6748
Affinity Capture-MS Homo sapiens
161 OXA1L  
Proximity Label-MS Homo sapiens
162 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
163 GSN 2934
Affinity Capture-MS Homo sapiens
164 ACTN1 87
Affinity Capture-MS Homo sapiens
165 MRPL44  
Proximity Label-MS Homo sapiens
166 ACOT1 641371
Proximity Label-MS Homo sapiens
167 RPL32 6161
Affinity Capture-MS Homo sapiens
168 VIPR2  
Affinity Capture-MS Homo sapiens
169 CYB5B 80777
Affinity Capture-MS Homo sapiens
170 CLN3 1201
Affinity Capture-MS Homo sapiens
171 MRPL21 219927
Proximity Label-MS Homo sapiens
172 SLC25A12 8604
Proximity Label-MS Homo sapiens
173 RPN2 6185
Affinity Capture-MS Homo sapiens
174 AIFM1 9131
Proximity Label-MS Homo sapiens
175 CANX 821
Affinity Capture-MS Homo sapiens
176 RAB7A 7879
Affinity Capture-MS Homo sapiens
177 DAP3 7818
Proximity Label-MS Homo sapiens
178 MRPS35 60488
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
179 NDUFA9 4704
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
180 ATP1A1 476
Affinity Capture-MS Homo sapiens
181 SMARCA5 8467
Affinity Capture-MS Homo sapiens
182 NDUFV2 4729
Proximity Label-MS Homo sapiens
183 PNN 5411
Affinity Capture-MS Homo sapiens
184 LETM1 3954
Proximity Label-MS Homo sapiens
185 RPL35 11224
Affinity Capture-MS Homo sapiens
186 UQCRC2 7385
Affinity Capture-MS Homo sapiens
187 MRPS7 51081
Proximity Label-MS Homo sapiens
188 MYL1 4632
Affinity Capture-MS Homo sapiens
189 LMNB2 84823
Affinity Capture-MS Homo sapiens
190 MRPS14  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
191 CRELD1 78987
Affinity Capture-MS Homo sapiens
192 ATP5F1 515
Proximity Label-MS Homo sapiens
193 RMND1 55005
Proximity Label-MS Homo sapiens
194 FKBP8 23770
Proximity Label-MS Homo sapiens
195 HNRNPA1L2 144983
Affinity Capture-MS Homo sapiens
196 ELAC2 60528
Proximity Label-MS Homo sapiens
197 H1F0 3005
Affinity Capture-MS Homo sapiens
198 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
199 PFN1 5216
Affinity Capture-MS Homo sapiens
200 AQP3  
Affinity Capture-MS Homo sapiens
201 VARS2  
Proximity Label-MS Homo sapiens
202 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
203 CLUH 23277
Proximity Label-MS Homo sapiens
204 RBBP4 5928
Affinity Capture-MS Homo sapiens
205 MYO1C 4641
Affinity Capture-MS Homo sapiens
206 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
207 SCYL2 55681
Affinity Capture-MS Homo sapiens
208 MRPL15 29088
Co-fractionation Homo sapiens
209 MTX2 10651
Proximity Label-MS Homo sapiens
210 SLC25A11 8402
Affinity Capture-MS Homo sapiens
211 ATP5J2 9551
Affinity Capture-MS Homo sapiens
212 MYO1D 4642
Affinity Capture-MS Homo sapiens
213 DKC1 1736
Affinity Capture-MS Homo sapiens
214 MYO6 4646
Affinity Capture-MS Homo sapiens
215 RPA3 6119
Proximity Label-MS Homo sapiens
216 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
217 TACO1  
Proximity Label-MS Homo sapiens
218 NAP1L1 4673
Affinity Capture-MS Homo sapiens
219 SET 6418
Affinity Capture-MS Homo sapiens
220 SF3B6 51639
Affinity Capture-MS Homo sapiens
221 DLST 1743
Proximity Label-MS Homo sapiens
222 TMOD3 29766
Affinity Capture-MS Homo sapiens
223 RPL35A 6165
Affinity Capture-MS Homo sapiens
224 RPL12 6136
Affinity Capture-MS Homo sapiens
225 NDUFA6  
Proximity Label-MS Homo sapiens
226 HNRNPAB 3182
Affinity Capture-MS Homo sapiens
227 MOB2 81532
Affinity Capture-MS Homo sapiens
228 RCN2 5955
Affinity Capture-MS Homo sapiens
229 MRPS16  
Proximity Label-MS Homo sapiens
230 DDRGK1 65992
Affinity Capture-MS Homo sapiens
231 CLPB 81570
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
232 VDAC1 7416
Affinity Capture-MS Homo sapiens
233 ATP5C1 509
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
234 COX2 4513
Proximity Label-MS Homo sapiens
235 MRPS17 51373
Proximity Label-MS Homo sapiens
236 PRPH 5630
Affinity Capture-MS Homo sapiens
237 ACOT2 10965
Proximity Label-MS Homo sapiens
238 RPL26 6154
Affinity Capture-MS Homo sapiens
239 ABCD3 5825
Proximity Label-MS Homo sapiens
240 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
241 AKAP1 8165
Proximity Label-MS Homo sapiens
242 MCUR1 63933