Gene description for NDUFAB1
Gene name NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
Gene symbol NDUFAB1
Other names/aliases ACP
Species Homo sapiens
 Database cross references - NDUFAB1
ExoCarta ExoCarta_4706
Entrez Gene 4706
HGNC 7694
MIM 603836
UniProt O14561  
 NDUFAB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NDUFAB1
Molecular Function
    calcium ion binding GO:0005509 NAS
    ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process GO:0000036 NAS
    fatty acid binding GO:0005504 ISS
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
Biological Process
    small molecule metabolic process GO:0044281 TAS
    protein lipoylation GO:0009249 IMP
    fatty acid biosynthetic process GO:0006633 NAS
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
    respiratory electron transport chain GO:0022904 TAS
    cellular metabolic process GO:0044237 TAS
Subcellular Localization
    mitochondrial membrane GO:0031966 NAS
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial respiratory chain complex I GO:0005747 NAS
    mitochondrial matrix GO:0005759 ISS
 Experiment description of studies that identified NDUFAB1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NDUFAB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NDUFAB1 is involved
Respiratory electron transport TAS Reactome

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