Gene description for ISCU
Gene name iron-sulfur cluster assembly enzyme
Gene symbol ISCU
Other names/aliases 2310020H20Rik
Species Homo sapiens
 Database cross references - ISCU
ExoCarta ExoCarta_23479
Entrez Gene 23479
HGNC 29882
MIM 611911
UniProt Q9H1K1  
 ISCU identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ISCU
Molecular Function
    iron ion binding GO:0005506 TAS
    iron-sulfur transferase activity GO:0036455 IBA
    protein complex scaffold GO:0032947 IDA
    ferrous iron binding GO:0008198 IBA
    protein binding GO:0005515 IPI
    2 iron, 2 sulfur cluster binding GO:0051537 IBA
    4 iron, 4 sulfur cluster binding GO:0051539 IBA
Biological Process
    [2Fe-2S] cluster assembly GO:0044571 IBA
    iron-sulfur cluster assembly GO:0016226 TAS
    nitrogen fixation GO:0009399 TAS
    cellular iron ion homeostasis GO:0006879 IBA
    protein maturation by iron-sulfur cluster transfer GO:0097428 IBA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
    mitochondrial matrix GO:0005759 TAS
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified ISCU in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ISCU
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFN 2810
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ISCU is involved
No pathways found

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