Gene description for NDUFA13
Gene name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Gene symbol NDUFA13
Other names/aliases B16.6
CDA016
CGI-39
GRIM-19
GRIM19
Species Homo sapiens
 Database cross references - NDUFA13
ExoCarta ExoCarta_51079
Vesiclepedia VP_51079
Entrez Gene 51079
HGNC 17194
MIM 609435
UniProt Q9P0J0  
 NDUFA13 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NDUFA13
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 NAS
    endopeptidase activator activity GO:0061133 IC
Biological Process
    aerobic respiration GO:0009060 NAS
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    cellular response to interferon-beta GO:0035458 IDA
    proton motive force-driven mitochondrial ATP synthesis GO:0042776 NAS
    protein insertion into mitochondrial inner membrane GO:0045039 IDA
    positive regulation of protein catabolic process GO:0045732 IGI
    negative regulation of DNA-templated transcription GO:0045892 IDA
    cellular response to retinoic acid GO:0071300 IDA
    extrinsic apoptotic signaling pathway GO:0097191 IEA
    positive regulation of execution phase of apoptosis GO:1900119 IGI
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial membrane GO:0031966 IDA
    respiratory chain complex I GO:0045271 IBA
    respiratory chain complex I GO:0045271 IDA
    respiratory chain complex I GO:0045271 IMP
    respiratory chain complex GO:0098803 IDA
 Experiment description of studies that identified NDUFA13 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDUFA13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 LIG4 3981
Two-hybrid Homo sapiens
3 AFG3L2 10939
Affinity Capture-MS Homo sapiens
4 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
5 SPRTN  
Affinity Capture-MS Homo sapiens
6 VAPA 9218
Affinity Capture-MS Homo sapiens
7 SLC22A12 116085
Affinity Capture-MS Homo sapiens
8 RPA2 6118
Proximity Label-MS Homo sapiens
9 NDUFB5 4711
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 UBE3A 7337
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 UBC 7316
Affinity Capture-MS Homo sapiens
12 NDUFA12 55967
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 LNPEP 4012
Affinity Capture-MS Homo sapiens
14 NDUFA4 4697
Affinity Capture-MS Homo sapiens
15 FFAR1  
Affinity Capture-MS Homo sapiens
16 NDUFS2 4720
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CCDC90B  
Proximity Label-MS Homo sapiens
18 NDUFB9 4715
Affinity Capture-MS Homo sapiens
19 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 COQ9  
Affinity Capture-MS Homo sapiens
21 NDUFA7 4701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
22 TIMMDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 FBXW7  
Affinity Capture-MS Homo sapiens
24 PRC1 9055
Affinity Capture-MS Homo sapiens
25 TIMM23 100287932
Affinity Capture-MS Homo sapiens
26 NDUFA5 4698
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 STAT3 6774
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
28 ABCE1 6059
Affinity Capture-MS Homo sapiens
29 Ncstn 59287
Affinity Capture-MS Mus musculus
30 CLPB 81570
Affinity Capture-MS Homo sapiens
31 NDUFA8 4702
Affinity Capture-MS Homo sapiens
32 NDUFAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 NDUFV3 4731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 EXOSC6 118460
Two-hybrid Homo sapiens
35 MECP2 4204
Affinity Capture-MS Homo sapiens
36 CPT2 1376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NDUFA6  
Affinity Capture-MS Homo sapiens
38 NDUFS1 4719
Affinity Capture-MS Homo sapiens
39 NDUFS5 4725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NDUFA1 4694
Affinity Capture-MS Homo sapiens
41 MDH2 4191
Proximity Label-MS Homo sapiens
42 APOO 79135
Proximity Label-MS Homo sapiens
43 KCNK1  
Affinity Capture-MS Homo sapiens
44 SLC25A10 1468
Co-fractionation Homo sapiens
45 NDUFS4 4724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 Tapt1  
Affinity Capture-MS Mus musculus
47 ACADVL 37
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 XRN1 54464
Two-hybrid Homo sapiens
49 BLM 641
Synthetic Growth Defect Homo sapiens
50 DIABLO 56616
Proximity Label-MS Homo sapiens
51 Klhl21  
Affinity Capture-MS Mus musculus
52 MYH9 4627
Cross-Linking-MS (XL-MS) Homo sapiens
53 ND1  
Affinity Capture-MS Homo sapiens
54 HBZ  
Affinity Capture-MS Homo sapiens
55 NDUFA2 4695
Affinity Capture-MS Homo sapiens
56 DNAJC30  
Affinity Capture-MS Homo sapiens
57 NDUFAF3 25915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 RTEL1 51750
Affinity Capture-MS Homo sapiens
59 NDUFV1 4723
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 Kif20a  
Affinity Capture-MS Mus musculus
61 C15orf48  
Affinity Capture-MS Homo sapiens
62 DUSP1  
Affinity Capture-MS Homo sapiens
63 SLC25A12 8604
Proximity Label-MS Homo sapiens
64 NDUFB10 4716
Affinity Capture-MS Homo sapiens
65 NDUFA9 4704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 GOLT1B 51026
Affinity Capture-MS Homo sapiens
67 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
68 ERCC8  
Affinity Capture-MS Homo sapiens
69 CST1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 L3MBTL3  
Affinity Capture-MS Homo sapiens
71 YME1L1 10730
Affinity Capture-MS Homo sapiens
72 NDUFB3 4709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 RPA3 6119
Proximity Label-MS Homo sapiens
74 GPR45  
Affinity Capture-MS Homo sapiens
75 TMOD1  
Affinity Capture-MS Homo sapiens
76 NDUFB6 4712
Co-fractionation Homo sapiens
77 ACAD9 28976
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 Cct8 12469
Affinity Capture-MS Mus musculus
79 NDUFA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 SLC22A20  
Affinity Capture-MS Homo sapiens
81 NDUFV2 4729
Affinity Capture-MS Homo sapiens
82 NDUFC2 4718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 NDUFB11 54539
Affinity Capture-MS Homo sapiens
84 HUWE1 10075
Affinity Capture-MS Homo sapiens
85 CLPP 8192
Proximity Label-MS Homo sapiens
86 HSPB2  
Two-hybrid Homo sapiens
87 Ercc6l  
Affinity Capture-MS Mus musculus
88 SLC25A6 293
Affinity Capture-MS Homo sapiens
89 ATP5J 522
Affinity Capture-MS Homo sapiens
90 UQCC1 55245
Affinity Capture-MS Homo sapiens
91 ICT1 3396
Affinity Capture-MS Homo sapiens
92 PYCARD 29108
Affinity Capture-MS Homo sapiens
93 TXNRD2 10587
Affinity Capture-MS Homo sapiens
94 SRP19 6728
Cross-Linking-MS (XL-MS) Homo sapiens
95 SQSTM1 8878
Proximity Label-MS Homo sapiens
96 Htt  
Affinity Capture-MS Mus musculus
97 NDUFB1 4707
Affinity Capture-MS Homo sapiens
98 DDX58 23586
Affinity Capture-RNA Homo sapiens
99 SFXN1 94081
Proximity Label-MS Homo sapiens
100 NDUFS8 4728
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 MTMR12 54545
Affinity Capture-MS Homo sapiens
102 TMEM126B 55863
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 EPHA2 1969
Affinity Capture-MS Homo sapiens
104 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 KRAS 3845
Negative Genetic Homo sapiens
106 C9orf72  
Affinity Capture-MS Homo sapiens
107 METTL17  
Proximity Label-MS Homo sapiens
108 ND4 4538
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ECSIT 51295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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