Gene description for TRIM26
Gene name tripartite motif containing 26
Gene symbol TRIM26
Other names/aliases AFP
RNF95
ZNF173
Species Homo sapiens
 Database cross references - TRIM26
ExoCarta ExoCarta_7726
Vesiclepedia VP_7726
Entrez Gene 7726
HGNC 12962
MIM 600830
UniProt Q12899  
 TRIM26 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Prostate cancer cells 25844599    
 Gene ontology annotations for TRIM26
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    suppression of viral release by host GO:0044790 IDA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IDA
    negative regulation of viral entry into host cell GO:0046597 IBA
    negative regulation of viral entry into host cell GO:0046597 IDA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    protein K11-linked ubiquitination GO:0070979 IDA
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TRIM26 in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for TRIM26
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 ZBTB38 253461
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 DACH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 LDHA 3939
Affinity Capture-MS Homo sapiens
5 DECR2 26063
Affinity Capture-MS Homo sapiens
6 MTCH1 23787
Affinity Capture-MS Homo sapiens
7 KRT6B 3854
Affinity Capture-MS Homo sapiens
8 LGALS3 3958
Affinity Capture-MS Homo sapiens
9 RPS3A 6189
Affinity Capture-MS Homo sapiens
10 RIN3  
Affinity Capture-MS Homo sapiens
11 AES 166
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 KLC3  
Affinity Capture-MS Homo sapiens
13 USP5 8078
Two-hybrid Homo sapiens
14 ALB 213
Affinity Capture-MS Homo sapiens
15 ARFGAP3 26286
Affinity Capture-MS Homo sapiens
16 TXNL1 9352
Affinity Capture-MS Homo sapiens
17 UBC 7316
Affinity Capture-MS Homo sapiens
18 PNMAL1  
Affinity Capture-MS Homo sapiens
19 CAND1 55832
Affinity Capture-MS Homo sapiens
20 CLTB 1212
Affinity Capture-MS Homo sapiens
21 SOX2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
22 DECR1 1666
Affinity Capture-MS Homo sapiens
23 RPS3 6188
Affinity Capture-MS Homo sapiens
24 APEX1 328
Affinity Capture-RNA Homo sapiens
25 PARK2  
Affinity Capture-MS Homo sapiens
26 RNF10  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
27 TRIM28 10155
Affinity Capture-MS Homo sapiens
28 C11orf30  
Affinity Capture-MS Homo sapiens
29 USP39 10713
Two-hybrid Homo sapiens
30 METTL8  
Affinity Capture-MS Homo sapiens
31 ANP32B 10541
Affinity Capture-MS Homo sapiens
32 FBXW7  
Affinity Capture-MS Homo sapiens
33 FKBP3 2287
Affinity Capture-MS Homo sapiens
34 ZNF460  
Affinity Capture-MS Homo sapiens
35 SRRM2 23524
Affinity Capture-MS Homo sapiens
36 RECQL4  
Affinity Capture-MS Homo sapiens
37 PSME1 5720
Affinity Capture-MS Homo sapiens
38 CTSZ 1522
Affinity Capture-MS Homo sapiens
39 CEP162  
Affinity Capture-MS Homo sapiens
40 EXD2  
Proximity Label-MS Homo sapiens
41 ANP32A 8125
Affinity Capture-MS Homo sapiens
42 PHB 5245
Affinity Capture-MS Homo sapiens
43 PHF7  
Two-hybrid Homo sapiens
44 H2AFY2 55506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 RNF126  
Two-hybrid Homo sapiens
46 ZNF418  
Affinity Capture-MS Homo sapiens
47 SLC7A11 23657
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
48 YAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 EEF1A1 1915
Affinity Capture-MS Homo sapiens
50 RPS2 6187
Affinity Capture-MS Homo sapiens
51 PCNA 5111
Affinity Capture-MS Homo sapiens
52 PES1 23481
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 FAS 355
Proximity Label-MS Homo sapiens
54 CASK 8573
Affinity Capture-MS Homo sapiens
55 MDH2 4191
Affinity Capture-MS Homo sapiens
56 LRRC59 55379
Proximity Label-MS Homo sapiens
57 TRIM41 90933
Two-hybrid Homo sapiens
58 SRP9 6726
Affinity Capture-MS Homo sapiens
59 TPD52L2 7165
Affinity Capture-MS Homo sapiens
60 TRIM26 7726
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
61 MEPCE 56257
Affinity Capture-MS Homo sapiens
62 PNKP 11284
Affinity Capture-MS Homo sapiens
63 STOM 2040
Affinity Capture-MS Homo sapiens
64 RABEP1 9135
Two-hybrid Homo sapiens
65 GOLGA8A 23015
Affinity Capture-MS Homo sapiens
66 IRF3 3661
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
67 MNAT1  
Two-hybrid Homo sapiens
68 YWHAE 7531
Affinity Capture-MS Homo sapiens
69 ANXA4 307
Affinity Capture-MS Homo sapiens
70 BEND7 222389
Two-hybrid Homo sapiens
71 DCTN1 1639
Proximity Label-MS Homo sapiens
72 KRT14 3861
Affinity Capture-MS Homo sapiens
73 CREB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ARRDC3 57561
Affinity Capture-MS Homo sapiens
75 Bag2  
Affinity Capture-MS Mus musculus
76 UBE2D3 7323
Two-hybrid Homo sapiens
77 HECTD1 25831
Affinity Capture-MS Homo sapiens
78 SON 6651
Co-fractionation Homo sapiens
79 H2AFY 9555
Two-hybrid Homo sapiens
80 ATP6V1E1 529
Affinity Capture-MS Homo sapiens
81 CT45A5  
Affinity Capture-MS Homo sapiens
82 SNAP29 9342
Affinity Capture-MS Homo sapiens
83 ENO1 2023
Affinity Capture-MS Homo sapiens
84 ANLN 54443
Affinity Capture-MS Homo sapiens
85 ECH1 1891
Affinity Capture-MS Homo sapiens
86 ZBTB2 57621
Affinity Capture-MS Homo sapiens
87 RBM39 9584
Affinity Capture-MS Homo sapiens
88 CHERP 10523
Affinity Capture-MS Homo sapiens
89 XPO1 7514
Affinity Capture-MS Homo sapiens
90 RPL35 11224
Affinity Capture-MS Homo sapiens
91 PSMD8 5714
Affinity Capture-MS Homo sapiens
92 PRDX1 5052
Affinity Capture-MS Homo sapiens
93 CUL3 8452
Affinity Capture-MS Homo sapiens
94 RPS6 6194
Affinity Capture-MS Homo sapiens
95 DCLRE1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 SUMO2 6613
Reconstituted Complex Homo sapiens
97 RPL7 6129
Affinity Capture-MS Homo sapiens
98 ZNF223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
100 THAP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
101 UBE2D2 7322
Two-hybrid Homo sapiens
102 EIF4H 7458
Affinity Capture-MS Homo sapiens
103 TPM1 7168
Affinity Capture-MS Homo sapiens
104 PCDH10 57575
Affinity Capture-MS Homo sapiens
105 DNAJC9 23234
Affinity Capture-MS Homo sapiens
106 TFPI2 7980
Affinity Capture-MS Homo sapiens
107 CHRM5  
Affinity Capture-MS Homo sapiens
108 TOP1 7150
Affinity Capture-MS Homo sapiens
109 OTUB2  
Two-hybrid Homo sapiens
110 CCDC124 115098
Affinity Capture-MS Homo sapiens
111 ACTB 60
Affinity Capture-MS Homo sapiens
112 MAGEA6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
113 DDRGK1 65992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 RNF2  
Affinity Capture-MS Homo sapiens
115 CCDC140  
Affinity Capture-MS Homo sapiens
116 KRT19 3880
Affinity Capture-MS Homo sapiens
117 RPL26 6154
Affinity Capture-MS Homo sapiens
118 WIBG 84305
Affinity Capture-MS Homo sapiens
119 TPM4 7171
Affinity Capture-MS Homo sapiens
120 PYHIN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 HUWE1 10075
Affinity Capture-MS Homo sapiens
122 TPM3 7170
Affinity Capture-MS Homo sapiens
123 UBE2D1 7321
Two-hybrid Homo sapiens
124 KRT18 3875
Affinity Capture-MS Homo sapiens
125 LLGL2 3993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 ZNF707  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 PRKCSH 5589
Affinity Capture-MS Homo sapiens
128 ZNF689  
Affinity Capture-MS Homo sapiens
129 KRT16 3868
Affinity Capture-MS Homo sapiens
130 FBXL6  
Proximity Label-MS Homo sapiens
131 HSPA8 3312
Affinity Capture-MS Homo sapiens
132 USP36  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
133 ZNF169 169841
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 INCA1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
135 IKBKG 8517
Affinity Capture-Western Homo sapiens
136 SQSTM1 8878
Proximity Label-MS Homo sapiens
137 UTP23  
Affinity Capture-MS Homo sapiens
138 BIVM  
Two-hybrid Homo sapiens
139 GNB1 2782
Affinity Capture-MS Homo sapiens
140 MYL12A 10627
Affinity Capture-MS Homo sapiens
141 PSMA1 5682
Affinity Capture-MS Homo sapiens
142 THAP7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 TBK1 29110
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
144 RBM4 5936
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
145 NEIL1  
Affinity Capture-MS Homo sapiens
146 NQO1 1728
Affinity Capture-MS Homo sapiens
147 C16orf72 29035
Affinity Capture-MS Homo sapiens
148 RPL7A 6130
Affinity Capture-MS Homo sapiens
149 ANXA5 308
Affinity Capture-MS Homo sapiens
150 RPS7 6201
Affinity Capture-MS Homo sapiens
151 STK11 6794
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
152 ORC1  
Affinity Capture-MS Homo sapiens
153 GNB2L1 10399
Affinity Capture-MS Homo sapiens
154 PHF10  
Affinity Capture-MS Homo sapiens
155 ANXA2 302
Affinity Capture-MS Homo sapiens
156 PTRF 284119
Affinity Capture-MS Homo sapiens
157 PHF8  
Affinity Capture-MS Homo sapiens
158 CEBPD  
Affinity Capture-MS Homo sapiens
159 MSRA 4482
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TRIM26 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome





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