Gene description for MARK3
Gene name MAP/microtubule affinity-regulating kinase 3
Gene symbol MARK3
Other names/aliases CTAK1
KP78
PAR1A
Par-1a
Species Homo sapiens
 Database cross references - MARK3
ExoCarta ExoCarta_4140
Entrez Gene 4140
HGNC 6897
MIM 602678
UniProt P27448  
 MARK3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MARK3
Molecular Function
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activity GO:0004674 IDA
    ATP binding GO:0005524 IEA
Biological Process
    protein phosphorylation GO:0006468 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified MARK3 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MARK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SFN 2810
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 YWHAQ 10971
Affinity Capture-MS Homo sapiens
3 CHGB  
Two-hybrid Homo sapiens
4 ATP6V0C 527
Two-hybrid Homo sapiens
5 YWHAG 7532
Affinity Capture-MS Homo sapiens
6 TTR 7276
Two-hybrid Homo sapiens
7 PNPLA2  
Two-hybrid Homo sapiens
8 RASGRF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 SAAL1  
Two-hybrid Homo sapiens
10 VPS11 55823
Two-hybrid Homo sapiens
11 YWHAB 7529
Affinity Capture-MS Homo sapiens
12 TCEA2  
Two-hybrid Homo sapiens
13 PMPCB  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MARK3 is involved
No pathways found





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