Gene description for TBL1X
Gene name transducin (beta)-like 1X-linked
Gene symbol TBL1X
Other names/aliases EBI
SMAP55
TBL1
Species Homo sapiens
 Database cross references - TBL1X
ExoCarta ExoCarta_6907
Entrez Gene 6907
HGNC 11585
MIM 300196
UniProt O60907  
 TBL1X identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TBL1X
Molecular Function
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    transcription regulatory region DNA binding GO:0044212 IDA
    transcription corepressor activity GO:0003714 IGI
    protein C-terminus binding GO:0008022 IPI
    protein domain specific binding GO:0019904 IPI
    transcription factor binding GO:0008134 IPI
    histone binding GO:0042393 IDA
Biological Process
    Notch signaling pathway GO:0007219 TAS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    sensory perception of sound GO:0007605 IMP
    histone deacetylation GO:0016575 IBA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    cellular lipid metabolic process GO:0044255 TAS
    transcription, DNA-templated GO:0006351 IEA
    chromatin organization GO:0006325 TAS
    canonical Wnt signaling pathway GO:0060070 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    proteolysis GO:0006508 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    histone deacetylase complex GO:0000118 IDA
    transcriptional repressor complex GO:0017053 IDA
    spindle microtubule GO:0005876 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified TBL1X in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TBL1X
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Affinity Capture-Western Homo sapiens
2 HIST2H3C 126961
Reconstituted Complex Homo sapiens
3 HIST2H2BE 8349
Reconstituted Complex Homo sapiens
4 CTNNB1 1499
Affinity Capture-Western Homo sapiens
5 HIST2H2AA3 8337
Reconstituted Complex Homo sapiens
6 MAP3K7IP2  
Reconstituted Complex Homo sapiens
7 SKP1 6500
Affinity Capture-Western Homo sapiens
8 HDAC3 8841
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 NCOR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
10 CACYBP 27101
Affinity Capture-Western Homo sapiens
11 HDAC5 10014
Affinity Capture-Western Homo sapiens
12 THRB 7068
Reconstituted Complex Homo sapiens
13 NCOR2  
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 GPS2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
15 HIST2H4A 8370
Reconstituted Complex Homo sapiens
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