ExoCarta: Gene summary

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Gene description for KDM1A
Gene name	lysine (K)-specific demethylase 1A
Gene symbol	KDM1A
Other names/aliases	AOF2 BHC110 KDM1 LSD1
Species	Homo sapiens
Database cross references - KDM1A
ExoCarta	ExoCarta_23028
Vesiclepedia	VP_23028
Entrez Gene	23028
HGNC	29079
MIM	609132
UniProt	O60341
KDM1A identified in sEVs derived from the following tissue/cell type
Chondrocytes	35931686
Chondrocytes	35931686
Hepatocellular carcinoma cells	26054723
Mesenchymal stem cells	36408942
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for KDM1A

Molecular Function
	p53 binding	GO:0002039	IPI
	chromatin binding	GO:0003682	IBA
	chromatin binding	GO:0003682	IDA
	transcription coactivator activity	GO:0003713	IDA
	transcription coactivator activity	GO:0003713	ISS
	protein binding	GO:0005515	IPI
	oxidoreductase activity	GO:0016491	IDA
	enzyme binding	GO:0019899	IPI
	nuclear receptor coactivator activity	GO:0030374	IMP
	demethylase activity	GO:0032451	IMP
	histone demethylase activity	GO:0032452	EXP
	histone demethylase activity	GO:0032452	IDA
	histone demethylase activity	GO:0032452	TAS
	histone H3K4 demethylase activity	GO:0032453	IDA
	histone H3K9 demethylase activity	GO:0032454	IDA
	histone H3K9 demethylase activity	GO:0032454	TAS
	telomeric DNA binding	GO:0042162	IDA
	identical protein binding	GO:0042802	IPI
	MRF binding	GO:0043426	IDA
	flavin adenine dinucleotide binding	GO:0050660	IBA
	flavin adenine dinucleotide binding	GO:0050660	IDA
	nuclear androgen receptor binding	GO:0050681	IDA
	RNA polymerase II-specific DNA-binding transcription factor binding	GO:0061629	ISS
	telomeric repeat-containing RNA binding	GO:0061752	IDA
	DNA-binding transcription factor binding	GO:0140297	IDA
	FAD-dependent H3K4me/H3K4me3 demethylase activity	GO:0140682	IBA
	FAD-dependent H3K4me/H3K4me3 demethylase activity	GO:0140682	IDA
	promoter-specific chromatin binding	GO:1990841	ISS
Biological Process
	negative regulation of transcription by RNA polymerase II	GO:0000122	IMP
	negative regulation of transcription by RNA polymerase II	GO:0000122	ISS
	positive regulation of neuroblast proliferation	GO:0002052	IMP
	regulation of transcription by RNA polymerase II	GO:0006357	IMP
	protein demethylation	GO:0006482	IMP
	regulation of double-strand break repair via homologous recombination	GO:0010569	IMP
	positive regulation of epithelial to mesenchymal transition	GO:0010718	IDA
	positive regulation of neuron projection development	GO:0010976	IEA
	cerebral cortex development	GO:0021987	IEA
	positive regulation of protein ubiquitination	GO:0031398	IMP
	negative regulation of protein binding	GO:0032091	IMP
	regulation of protein localization	GO:0032880	IMP
	cellular response to UV	GO:0034644	IDA
	epigenetic regulation of gene expression	GO:0040029	IBA
	neuron maturation	GO:0042551	IEA
	negative regulation of DNA binding	GO:0043392	IC
	negative regulation of DNA-binding transcription factor activity	GO:0043433	IDA
	negative regulation of DNA-binding transcription factor activity	GO:0043433	IMP
	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:0043518	IMP
	positive regulation of cell size	GO:0045793	IEA
	negative regulation of DNA-templated transcription	GO:0045892	IDA
	positive regulation of transcription by RNA polymerase II	GO:0045944	IDA
	positive regulation of transcription by RNA polymerase II	GO:0045944	ISS
	guanine metabolic process	GO:0046098	IEA
	muscle cell development	GO:0055001	ISS
	regulation of androgen receptor signaling pathway	GO:0060765	TAS
	response to fungicide	GO:0060992	IEA
	cellular response to cAMP	GO:0071320	IEA
	cellular response to gamma radiation	GO:0071480	IMP
	positive regulation of cold-induced thermogenesis	GO:0120162	ISS
	DNA repair-dependent chromatin remodeling	GO:0140861	IDA
	negative regulation of transcription initiation-coupled chromatin remodeling	GO:0160217	IDA
	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:1902166	IMP
	positive regulation of neural precursor cell proliferation	GO:2000179	ISS
	positive regulation of stem cell proliferation	GO:2000648	ISS
Subcellular Localization
	chromosome, telomeric region	GO:0000781	IDA
	chromatin	GO:0000785	IBA
	chromatin	GO:0000785	IDA
	chromatin	GO:0000785	IDA
	chromatin	GO:0000785	ISS
	nucleus	GO:0005634	IBA
	nucleus	GO:0005634	IDA
	nucleus	GO:0005634	IDA
	nucleoplasm	GO:0005654	IDA
	nucleoplasm	GO:0005654	TAS
	transcription regulator complex	GO:0005667	ISS
	protein-containing complex	GO:0032991	IDA
	DNA repair complex	GO:1990391	IDA

Experiment description of studies that identified KDM1A in sEVs

Experiment ID

497

MISEV standards
✘	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

"Varela-EirÃn M, Carpintero-FernÃ¡ndez P, GuitiÃ¡n-CaamaÃ±o A, Varela-VÃ¡zquez A, GarcÃa-Yuste A, SÃ¡nchez-Temprano A, Bravo-LÃ³pez SB, YaÃ±ez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, MayÃ¡n MD."

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

498

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

235

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|Alix\|HSC70\|GAPDH	Enriched markers
✔ HSP90B1	Negative markers
✔ qNano	Particle analysis

Identified molecule

mRNA

Identification method

RNA Sequencing

PubMed ID

26054723

Organism

Homo sapiens

Experiment description

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

Authors

"He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"

Journal name

Carcinogenesis

Publication year

2015

Sample

Hepatocellular carcinoma cells

Sample name

HKCI-8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.19 g/mL

Molecules identified in the study

Protein
RNA

Methods used in the study

Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing

Experiment ID

488

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD81\|CD63\|GAPDH\|SDCBP\|LAMP1\|TFRC\|UCHL1\|FLOT2\|LAMP2\|FLOT1\|ICAM1\|RAB5B\|CD151\|RAB35\|TSG101\|RAB5A\|CD82	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Homo sapiens

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Mesenchymal stem cells

Sample name

UCMSC

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

211

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|Alix\|EpCAM\|TFRC	Enriched markers
✔ cytochrome c\|GOLGA2	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23333927

Organism

Homo sapiens

Experiment description

Characterization and proteomic analysis of ovarian cancer-derived exosomes.

Authors

"Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."

Journal name

J Proteomics

Publication year

2013

Sample

Ovarian cancer cells

Sample name

IGROV1

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.09-1.15 g/mL

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Experiment ID

212

MISEV standards
✔ CEM	Biophysical techniques
✔ TSG101\|Alix\|EpCAM\|TFRC	Enriched markers
✔ Cytochrome C\|GOLGA2	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23333927

Organism

Homo sapiens

Experiment description

Characterization and proteomic analysis of ovarian cancer-derived exosomes.

Authors

"Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."

Journal name

J Proteomics

Publication year

2013

Sample

Ovarian cancer cells

Sample name

OVCAR-3

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.09-1.15 g/mL

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Experiment ID

217

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|CD81\|CD9\|CD63	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23844026

Organism

Homo sapiens

Experiment description

Characterization of human thymic exosomes.

Authors

"Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."

Journal name

PLoS One

Publication year

2013

Sample

Thymus

Sample name

Normal-Thymus

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for KDM1A

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

HIST2H2BE

8349

Affinity Capture-MS

Homo sapiens

MNS1

55329

Two-hybrid

Homo sapiens

RASSF8

11228

Two-hybrid

Homo sapiens

MYLIP

Two-hybrid

Homo sapiens

HDAC2

3066

Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

PEX7

Two-hybrid

Homo sapiens

KRT6A

3853

Two-hybrid

Homo sapiens

CSNK1A1

1452

Affinity Capture-Western

Homo sapiens

EIF2AK1

Proximity Label-MS

Homo sapiens

BRCA1

672

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

C9orf78

51759

Affinity Capture-MS

Homo sapiens

ZNF71

Two-hybrid

Homo sapiens

CSNK2A1

1457

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens

IGFBP4

3487

Two-hybrid

Homo sapiens

HSPA1A

3303

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

SOX2

Affinity Capture-MS

Homo sapiens

PMF1

Two-hybrid

Homo sapiens

CCDC90B

Two-hybrid

Homo sapiens

CPSF2

53981

Co-fractionation

Homo sapiens

HDAC3

8841

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

WDR76

Affinity Capture-MS

Homo sapiens

MTF2

Two-hybrid

Homo sapiens

ERC1

23085

Proximity Label-MS

Homo sapiens

ELOF1

Two-hybrid

Homo sapiens

OIP5

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

MARCH5

Affinity Capture-MS

Homo sapiens

DYNLL1

8655

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CENPQ

Two-hybrid

Homo sapiens

FIGNL1

63979

Two-hybrid

Homo sapiens

UCHL5

51377

Two-hybrid

Homo sapiens

HMG20B

Co-purification		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

METTL18

Affinity Capture-MS

Homo sapiens

NSFL1C

55968

Proximity Label-MS

Homo sapiens

PPP6R3

55291

Co-fractionation

Homo sapiens

WDR5

11091

Co-fractionation

Homo sapiens

RCOR3

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Co-fractionation		Homo sapiens

TRIM4

89122

Affinity Capture-Western

Homo sapiens

MTA2

9219

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

GFI1B

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Protein-peptide		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens

RASSF2

9770

Two-hybrid

Homo sapiens

UNK

Affinity Capture-RNA

Homo sapiens

RBBP5

5929

Co-fractionation

Homo sapiens

BATF

Two-hybrid

Homo sapiens

CTBP1

1487

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CCDC132

55610

Affinity Capture-MS

Homo sapiens

PRDM2

Proximity Label-MS

Homo sapiens

ZMYM3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Co-fractionation		Homo sapiens

OFD1

8481

Proximity Label-MS

Homo sapiens

CEP152

Proximity Label-MS

Homo sapiens

SLC25A20

788

Affinity Capture-Western

Homo sapiens

FYN

2534

Two-hybrid

Homo sapiens

FAM9A

Two-hybrid

Homo sapiens

METTL21C

Affinity Capture-MS

Homo sapiens

ASCC2

84164

Two-hybrid

Homo sapiens

ZNF581

Two-hybrid

Homo sapiens

USP28

57646

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

ID2

Two-hybrid

Homo sapiens

SPATA22

Two-hybrid

Homo sapiens

ZNF280D

Proximity Label-MS

Homo sapiens

KIF15

56992

Proximity Label-MS

Homo sapiens

SIRT7

Affinity Capture-MS

Homo sapiens

EPAS1

Affinity Capture-MS

Homo sapiens

TAL1

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

CUL3

8452

Affinity Capture-MS

Homo sapiens

MYCBP

26292

Proximity Label-MS

Homo sapiens

KLHDC4

54758

Two-hybrid

Homo sapiens

RBBP4

5928

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

ARHGAP15

55843

Two-hybrid

Homo sapiens

ZSCAN5A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

LOXL4

84171

Two-hybrid

Homo sapiens

RPA3

6119

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

ESCO1

Affinity Capture-Western

Homo sapiens

ZMYND8

23613

Affinity Capture-MS

Homo sapiens

MALT1

10892

Two-hybrid

Homo sapiens

SH3GLB2

56904

Two-hybrid

Homo sapiens

CRYBG3

Proximity Label-MS

Homo sapiens

KRT19

3880

Two-hybrid

Homo sapiens

NFATC2

Affinity Capture-MS

Homo sapiens

KRT222

125113

Two-hybrid

Homo sapiens

ECE2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HAUS3

Two-hybrid

Homo sapiens

HESX1

Two-hybrid

Homo sapiens

GOLGB1

2804

Proximity Label-MS

Homo sapiens

ASB3

51130

Two-hybrid

Homo sapiens

MTA1

9112

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

ZEB1

Affinity Capture-MS

Homo sapiens

ZBP1

Affinity Capture-MS

Homo sapiens

FYCO1

79443

Two-hybrid

Homo sapiens

SAMD3

Two-hybrid

Homo sapiens

PRAME

Affinity Capture-MS

Homo sapiens

3550

Two-hybrid

Homo sapiens

TCF4

Affinity Capture-MS

Homo sapiens

GOLGA5

9950

Affinity Capture-MS

Homo sapiens

C17orf82

Two-hybrid

Homo sapiens

HIST1H4J

8363

Proximity Label-MS

Homo sapiens

ZNF641

Two-hybrid

Homo sapiens

PDE4DIP

9659

Two-hybrid

Homo sapiens

DNMT1

1786

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

SP7

Proximity Label-MS

Homo sapiens

100

HIST1H2BD

3017

Proximity Label-MS

Homo sapiens

101

KRT7

3855

Two-hybrid

Homo sapiens

102

SMARCC2

6601

Co-fractionation

Homo sapiens

103

CDCA5

Two-hybrid

Homo sapiens

104

CCDC151

Two-hybrid

Homo sapiens

105

SNX15

Two-hybrid

Homo sapiens

106

EXOC1

55763

Two-hybrid

Homo sapiens

107

KRT6B

3854

Two-hybrid

Homo sapiens

108

TEX35

Two-hybrid

Homo sapiens

109

CTBP2

1488

Affinity Capture-MS

Homo sapiens

110

DNTTIP1

116092

Two-hybrid

Homo sapiens

111

RPA2

6118

Affinity Capture-MS

Homo sapiens

112

HIST1H2BG

8339

Proximity Label-MS

Homo sapiens

113

APC

Proximity Label-MS

Homo sapiens

114

NUDCD3

23386

Proximity Label-MS

Homo sapiens

115

OFCC1

Two-hybrid

Homo sapiens

116

RABGAP1L

9910

Affinity Capture-MS

Homo sapiens

117

SETDB1

Two-hybrid

Homo sapiens

118

WDR83

Two-hybrid

Homo sapiens

119

CCDC14

Two-hybrid

Homo sapiens

120

CCDC53

51019

Two-hybrid

Homo sapiens

121

OBSL1

23363

Affinity Capture-MS

Homo sapiens

122

STIP1

10963

Proximity Label-MS

Homo sapiens

123

TSACC

Two-hybrid

Homo sapiens

124

KHDRBS1

10657

Co-fractionation

Homo sapiens

125

MLC1

23209

Two-hybrid

Homo sapiens

126

PHF1

Affinity Capture-Western

Homo sapiens

127

TIMM50

92609

Co-fractionation

Homo sapiens

128

USP7

7874

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

129

ZNF280C

Proximity Label-MS

Homo sapiens

130

GSK3B

2932

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens

131

C18orf54

Two-hybrid

Homo sapiens

132

KANSL1

Two-hybrid

Homo sapiens

133

GTF2I

2969

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

134

Mef2d

17261

Affinity Capture-Western		Mus musculus
Affinity Capture-Western		Mus musculus

135

CCDC172

Two-hybrid

Homo sapiens

136

USP15

9958

Co-fractionation

Homo sapiens

137

SYMPK

8189

Co-fractionation

Homo sapiens

138

LINC00511

Protein-RNA

Homo sapiens

139

HIST1H4A

8359

Affinity Capture-MS

Homo sapiens

140

WHSC1

7468

Affinity Capture-Western

Homo sapiens

141

NR1H3

Two-hybrid

Homo sapiens

142

NDUFA8

4702

Two-hybrid

Homo sapiens

143

ZNF480

147657

Two-hybrid

Homo sapiens

144

E2F1

1869

Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens

145

HIST2H3D

653604

Proximity Label-MS

Homo sapiens

146

S100A8

6279

Affinity Capture-MS

Homo sapiens

147

NR2E1

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

148

ASB10

Two-hybrid

Homo sapiens

149

MBD2

8932

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

150

ATP6V1B1

525

Two-hybrid

Homo sapiens

151

Proximity Label-MS

Homo sapiens

152

CCDC74B

Two-hybrid

Homo sapiens

153

CRLF3

51379

Two-hybrid

Homo sapiens

154

C8orf48

Two-hybrid

Homo sapiens

155

VPS11

55823

Two-hybrid

Homo sapiens

156

SEPT6

23157

Two-hybrid

Homo sapiens

157

ZFP28

Two-hybrid

Homo sapiens

158

NBPF15

Two-hybrid

Homo sapiens

159

YEATS4

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

160

PHF13

Affinity Capture-MS

Homo sapiens

161

SMARCAD1

Affinity Capture-MS

Homo sapiens

162

TP53BP1

7158

Reconstituted Complex

Homo sapiens

163

SOX6

Proximity Label-MS

Homo sapiens

164

GLMN

11146

Proximity Label-MS

Homo sapiens

165

ZBTB24

Two-hybrid

Homo sapiens

166

IKZF3

Affinity Capture-MS

Homo sapiens

167

AKAP9

10142

Two-hybrid

Homo sapiens

168

C11orf49

Proximity Label-MS

Homo sapiens

169

PHLDB3

Affinity Capture-MS

Homo sapiens

170

ATP5F1

515

Affinity Capture-MS

Homo sapiens

171

RASSF1

Two-hybrid

Homo sapiens

172

ADNP

23394

Proximity Label-MS

Homo sapiens

173

HOXA1

3198

Two-hybrid

Homo sapiens

174

IKZF1

Affinity Capture-MS

Homo sapiens

175

C8orf74

Two-hybrid

Homo sapiens

176

EFTUD2

9343

Co-fractionation

Homo sapiens

177

ATP5J2

9551

Two-hybrid

Homo sapiens

178

MYC

Two-hybrid

Homo sapiens

179

EHMT1

Co-fractionation

Homo sapiens

180

CSNK2A2

1459

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens

181

EHMT2

10919

Co-fractionation

Homo sapiens

182

CEP131

22994

Proximity Label-MS

Homo sapiens

183

Dynll1

56455

Affinity Capture-MS

Mus musculus

184

CCDC37

348807

Two-hybrid

Homo sapiens

185

SLU7

Two-hybrid

Homo sapiens

186

SNF8

11267

Two-hybrid

Homo sapiens

187

TRIM39

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

188

HMG20A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

189

SF3A3

10946

Co-fractionation

Homo sapiens

190

TEX9

Two-hybrid		Homo sapiens
Proximity Label-MS		Homo sapiens

191

TAF6

6878

Co-fractionation

Homo sapiens

192

STX19

Two-hybrid

Homo sapiens

193

SERGEF

Two-hybrid

Homo sapiens

194

CDCA4

55038

Two-hybrid

Homo sapiens

195

MAX

Affinity Capture-MS

Homo sapiens

196

NMI

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

197

KLF3

Two-hybrid		Homo sapiens
Proximity Label-MS		Homo sapiens

198

TUFT1

Affinity Capture-MS

Homo sapiens

199

PHF19

Two-hybrid

Homo sapiens

200

FKBP4

2288

Proximity Label-MS

Homo sapiens

201

TSC1

7248

Two-hybrid

Homo sapiens

202

OTUB1

55611

Two-hybrid

Homo sapiens

203

ESR1

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

204

HSPA1B

3304

Proximity Label-MS

Homo sapiens

205

KRT38

8687

Two-hybrid

Homo sapiens

206

KIAA1217

56243

Proximity Label-MS

Homo sapiens

207

ARHGAP29

9411

Two-hybrid

Homo sapiens

208

TCF3

Affinity Capture-MS

Homo sapiens

209

GLYR1

84656

Two-hybrid

Homo sapiens

210

MTA3

57504

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

211

PHC2

Two-hybrid

Homo sapiens

212

PTRF

284119

Affinity Capture-MS

Homo sapiens

213

PRMT1

3276

Affinity Capture-Western

Homo sapiens

214

RCOR1

Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-crystal Structure		Homo sapiens
Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens

215

ESCO2

Affinity Capture-Western

Homo sapiens

216

DBF4B

80174

Two-hybrid

Homo sapiens

217

BAHD1

Two-hybrid

Homo sapiens

218

UBE2H

7328

Affinity Capture-MS

Homo sapiens

219

HNRNPC

3183

Co-fractionation

Homo sapiens

220

DLG5

9231

Proximity Label-MS

Homo sapiens

221

CBX1

10951

Affinity Capture-MS

Homo sapiens

222

NDUFS1

4719

Two-hybrid

Homo sapiens

223

ALMS1

Proximity Label-MS

Homo sapiens

224

KRT17

3872

Two-hybrid

Homo sapiens

225

MBD4

Two-hybrid

Homo sapiens

226

GATA2

Proximity Label-MS

Homo sapiens

227

GDF9

2661

Two-hybrid

Homo sapiens

228

EML4

27436

Co-fractionation

Homo sapiens

229

TXNL1

9352

Proximity Label-MS

Homo sapiens

230

GRIPAP1

56850

Affinity Capture-MS

Homo sapiens

231

RCOR2

283248

Proximity Label-MS

Homo sapiens

232

SAMD1

Affinity Capture-MS

Homo sapiens

233

IL16

Two-hybrid

Homo sapiens

234

UNKL

Two-hybrid

Homo sapiens

235

MTMR9

66036

Two-hybrid

Homo sapiens

236

TRIM54

Two-hybrid

Homo sapiens

237

CCDC74A

Two-hybrid

Homo sapiens

238

TRIM28

10155

Affinity Capture-Western

Homo sapiens

239

TNRC6A

27327

Proximity Label-MS

Homo sapiens

240

IFT74

80173

Proximity Label-MS

Homo sapiens

241

ZNF436

Two-hybrid

Homo sapiens

242

SOGA1

140710

Proximity Label-MS

Homo sapiens

243

NAV1

89796

Proximity Label-MS

Homo sapiens

244

SUV39H1

Two-hybrid

Homo sapiens

245

STAT3

6774

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

246

ATG16L1

55054

Affinity Capture-MS

Homo sapiens

247

CEP44

Proximity Label-MS

Homo sapiens

248

CSNK2B

1460

Affinity Capture-MS

Homo sapiens

249

SMARCA2

6595

Co-fractionation

Homo sapiens

250

RBPJ

3516

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

251

GOLGA2

2801

Two-hybrid

Homo sapiens

252

PPM1D

Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

253

NF2

4771

Two-hybrid		Homo sapiens
Proximity Label-MS		Homo sapiens

254

PHF20L1

Two-hybrid

Homo sapiens

255

FOXC1

Affinity Capture-MS

Homo sapiens

256

SPATA24

Two-hybrid

Homo sapiens

257

CDC23

8697

Two-hybrid

Homo sapiens

258

MTO1

Two-hybrid

Homo sapiens

259

PNKP

11284

Two-hybrid

Homo sapiens

260

SNAI2

Affinity Capture-Western

Homo sapiens

261

BAIAP2

10458

Two-hybrid

Homo sapiens

262

ITGB3BP

Two-hybrid

Homo sapiens

263

SOCS6

Two-hybrid

Homo sapiens

264

PDCD5

9141

Two-hybrid

Homo sapiens

265

MKRN2

23609

Affinity Capture-RNA

Homo sapiens

266

ZNF451

26036

Two-hybrid

Homo sapiens

267

TNPO2

30000

Co-fractionation

Homo sapiens

268

FGG

2266

Affinity Capture-MS

Homo sapiens

269

ZCCHC17

Two-hybrid

Homo sapiens

270

NTRK1

4914

Affinity Capture-MS

Homo sapiens

271

ZNF333

Two-hybrid

Homo sapiens

272

DNAJA1

3301

Co-fractionation

Homo sapiens

273

TACC1

6867

Two-hybrid

Homo sapiens

274

UNC119

9094

Two-hybrid

Homo sapiens

275

COPS3

8533

Co-fractionation

Homo sapiens

276

UBA3

9039

Two-hybrid

Homo sapiens

277

PELP1

27043

Reconstituted Complex		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens

278

HDAC5

10014

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

279

C16orf59

80178

Two-hybrid

Homo sapiens

280

H3F3C

440093

Two-hybrid

Homo sapiens

281

ZBED1

Two-hybrid

Homo sapiens

282

RAN

5901

Co-fractionation

Homo sapiens

283

POLR2B

5431

Affinity Capture-MS

Homo sapiens

284

SF3B2

10992

Two-hybrid

Homo sapiens

285

SMARCD1

6602

Two-hybrid

Homo sapiens

286

ECT2

1894

Affinity Capture-MS

Homo sapiens

287

CRYAA

1409

Affinity Capture-MS

Homo sapiens

288

TNNT2

Two-hybrid

Homo sapiens

289

DOK4

55715

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

290

NR3C1

2908

Proximity Label-MS

Homo sapiens

291

TP73

Affinity Capture-Western

Homo sapiens

292

SAP30

8819

Co-fractionation

Homo sapiens

293

HNF4A

Proximity Label-MS

Homo sapiens

294

VPS37A

137492

Two-hybrid

Homo sapiens

295

NEFL

4747

Two-hybrid

Homo sapiens

296

SMAD9

Two-hybrid

Homo sapiens

297

RUVBL2

10856

Co-fractionation

Homo sapiens

298

SH3D19

152503

Proximity Label-MS

Homo sapiens

299

TTC1

7265

Proximity Label-MS

Homo sapiens

300

FLII

2314

Co-fractionation

Homo sapiens

301

RNF2

Affinity Capture-MS

Homo sapiens

302

CEP350

9857

Proximity Label-MS

Homo sapiens

303

SFMBT1

51460

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

304

NCAPG

64151

Co-fractionation

Homo sapiens

305

TPM3

7170

Affinity Capture-MS

Homo sapiens

306

IMMT

10989

Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

307

DZIP3

Affinity Capture-MS

Homo sapiens

308

HAUS1

Two-hybrid

Homo sapiens

309

LLGL2

3993

Affinity Capture-MS

Homo sapiens

310

INSM1

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

311

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

312

SMN1

6606

Two-hybrid

Homo sapiens

313

SIN3A

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

314

ISL1

Two-hybrid

Homo sapiens

315

RPA1

6117

Affinity Capture-MS

Homo sapiens

316

BLZF1

Two-hybrid

Homo sapiens

317

LENG8

Two-hybrid

Homo sapiens

318

DDX58

23586

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

319

CCDC93

54520

Affinity Capture-MS

Homo sapiens

320

TRIM25

7706

Affinity Capture-Western

Homo sapiens

321

UBE3C

9690

Co-fractionation

Homo sapiens

322

TLR9

Affinity Capture-MS

Homo sapiens

323

KDM1A

23028

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens

324

CIT

11113

Affinity Capture-MS

Homo sapiens

325

UHRF1

29128

Affinity Capture-Western

Homo sapiens

326

STX11

8676

Two-hybrid

Homo sapiens

327

367

Affinity Capture-Western		Homo sapiens
Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

328

LTF

4057

Affinity Capture-MS

Homo sapiens

329

POGZ

23126

Proximity Label-MS

Homo sapiens

330

GTPBP2

54676

Two-hybrid

Homo sapiens

331

BCAT1

586

Two-hybrid

Homo sapiens

332

NOTCH1

4851

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

333

HIST1H2AE

3012

Proximity Label-MS

Homo sapiens

334

EP300

2033

Affinity Capture-Western

Homo sapiens

335

VARS

7407

Co-fractionation

Homo sapiens

336

CRBN

Two-hybrid

Homo sapiens

337

MCRS1

Two-hybrid

Homo sapiens

338

PRIM2

5558

Two-hybrid

Homo sapiens

339

NECAB2

Two-hybrid

Homo sapiens

340

TRAF4

9618

Two-hybrid

Homo sapiens

341

KIFC3

3801

Two-hybrid

Homo sapiens

342

TADA3

Two-hybrid

Homo sapiens

343

Mef2c

Affinity Capture-Western

Mus musculus

344

DVL3

1857

Proximity Label-MS

Homo sapiens

345

GFI1

Affinity Capture-Western

Homo sapiens

346

ARNTL

Affinity Capture-MS

Homo sapiens

347

KIAA1429

25962

Affinity Capture-MS

Homo sapiens

348

GPATCH2L

Two-hybrid

Homo sapiens

349

GSTCD

79807

Two-hybrid

Homo sapiens

350

PPP1R12A

4659

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens

351

RNF10

Two-hybrid

Homo sapiens

352

CEP70

Two-hybrid

Homo sapiens

353

GSE1

23199

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Co-fractionation		Homo sapiens

354

TBL1XR1

79718

Affinity Capture-MS

Homo sapiens

355

GABPB2

Two-hybrid

Homo sapiens

356

KIF5B

3799

Co-fractionation

Homo sapiens

357

NR2C2

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

358

PSMD9

5715

Affinity Capture-MS

Homo sapiens

359

HAUS6

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

360

CEP162

Two-hybrid

Homo sapiens

361

EED

Affinity Capture-MS

Homo sapiens

362

BMP3

651

Two-hybrid

Homo sapiens

363

NR2C1

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

364

VPS53

55275

Affinity Capture-MS

Homo sapiens

365

SLC4A1AP

Co-fractionation

Homo sapiens

366

CHD3

1107

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

367

SMARCB1

6598

Co-fractionation

Homo sapiens

368

PSMC3

5702

Two-hybrid

Homo sapiens

369

DVL2

1856

Proximity Label-MS

Homo sapiens

370

RNF135

Affinity Capture-Western

Homo sapiens

371

USP22

23326

Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

372

RB1

5925

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

373

E2F4

Affinity Capture-MS

Homo sapiens

374

CLOCK

Affinity Capture-MS

Homo sapiens

375

SRGAP3

Two-hybrid

Homo sapiens

376

PRDM1

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

377

IKBIP

121457

Two-hybrid

Homo sapiens

378

ARRDC1

92714

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

379

SMARCA5

8467

Co-fractionation

Homo sapiens

380

NR1H2

Two-hybrid

Homo sapiens

381

SDCCAG3

Proximity Label-MS

Homo sapiens

382

PSMC1

5700

Two-hybrid

Homo sapiens

383

ITSN2

50618

Two-hybrid

Homo sapiens

384

UBE2I

7329

Biochemical Activity

Homo sapiens

385

GCC2

9648

Proximity Label-MS

Homo sapiens

386

FAM110D

Affinity Capture-MS

Homo sapiens

387

GATA3

Proximity Label-MS

Homo sapiens

388

RNF168

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

389

KDM5B

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

390

PPARD

Two-hybrid

Homo sapiens

391

SUMO2

6613

Reconstituted Complex

Homo sapiens

392

WBSCR27

Two-hybrid

Homo sapiens

393

ANKEF1

Two-hybrid

Homo sapiens

394

RBBP7

5931

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

395

DYNLL2

140735

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

396

MBD3

53615

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

397

CEBPA

Proximity Label-MS

Homo sapiens

398

ZNF516

9658

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

399

SSX2IP

Two-hybrid

Homo sapiens

400

PHF21B

Affinity Capture-MS

Homo sapiens

401

SPSB1

Two-hybrid

Homo sapiens

402

COPS2

9318

Co-fractionation

Homo sapiens

403

HIST1H3A

8350

Biochemical Activity		Homo sapiens
Protein-peptide		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens

404

FANCD2

Affinity Capture-MS

Homo sapiens

405

KRT33B

3884

Two-hybrid

Homo sapiens

406

HIST2H3C

126961

Co-crystal Structure		Homo sapiens
Biochemical Activity		Homo sapiens

407

CTNNB1

1499

Affinity Capture-Western

Homo sapiens

408

NOSTRIN

115677

Two-hybrid

Homo sapiens

409

FOXG1

Affinity Capture-MS

Homo sapiens

410

RPRD1A

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

411

ZNF829

Two-hybrid

Homo sapiens

412

CCDC155

Two-hybrid

Homo sapiens

413

BCL3

Affinity Capture-Western

Homo sapiens

414

AP1G2

8906

Two-hybrid

Homo sapiens

415

Myod1

Affinity Capture-Western

Mus musculus

416

ECI2

10455

Two-hybrid

Homo sapiens

417

DYX1C1

Two-hybrid

Homo sapiens

418

L3MBTL3

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

419

IFI35

3430

Two-hybrid

Homo sapiens

420

SPZ1

Two-hybrid

Homo sapiens

421

NIN

51199

Proximity Label-MS

Homo sapiens

422

PHF21A

Co-purification		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

423

RREB1

6239

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Co-fractionation		Homo sapiens

424

RPAP3

79657

Proximity Label-MS

Homo sapiens

425

MYT1

Proximity Label-MS

Homo sapiens

426

PLEKHG3

26030

Affinity Capture-MS

Homo sapiens

427

ZMYM2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Co-fractionation		Homo sapiens

428

Cbx1

Affinity Capture-MS

Mus musculus

429

SPICE1

Two-hybrid		Homo sapiens
Proximity Label-MS		Homo sapiens

430

SIRT6

Affinity Capture-MS

Homo sapiens

431

SPRY2

10253

Two-hybrid

Homo sapiens

432

SNAI1

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

433

TTC33

Two-hybrid

Homo sapiens

434

C15orf27

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

435

TNFAIP1

7126

Two-hybrid

Homo sapiens

436

TDO2

Two-hybrid

Homo sapiens

437

SMARCC1

6599

Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens

438

SAP18

10284

Co-fractionation

Homo sapiens

439

HMGN5

79366

Affinity Capture-MS

Homo sapiens

440

DNAJA3

9093

Two-hybrid

Homo sapiens

441

INTS2

Two-hybrid

Homo sapiens

442

OPA3

80207

Two-hybrid

Homo sapiens

443

HDAC1

3065

Co-purification		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

444

CHD4

1108

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

445

KLC3

Two-hybrid

Homo sapiens

446

TP53

7157

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Negative Genetic		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens

447

UBB

7314

Proximity Label-MS

Homo sapiens

448

MCPH1

Two-hybrid

Homo sapiens

449

TERF1

7013

Two-hybrid

Homo sapiens

450

ZNF217

7764

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Co-fractionation		Homo sapiens

451

EZH2

Two-hybrid

Homo sapiens

452

CCDC121

Two-hybrid

Homo sapiens

453

ACTA2

Proximity Label-MS

Homo sapiens

454

KIF1BP

26128

Proximity Label-MS

Homo sapiens

455

Ufl1

Affinity Capture-MS

Mus musculus

456

C9orf72

Affinity Capture-MS

Homo sapiens

457

KBTBD4

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

458

C4orf17

Two-hybrid

Homo sapiens

459

KIAA0408

Two-hybrid

Homo sapiens

460

FGF1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

461

CDC5L

988

Two-hybrid		Homo sapiens
Co-fractionation		Homo sapiens

462

ZNF280A

Two-hybrid

Homo sapiens

View the network

Pathways in which KDM1A is involved

Pathway	Evidence	Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	TAS	Reactome
Chromatin modifying enzymes	TAS	Reactome
Chromatin organization	TAS	Reactome
Disease	TAS	Reactome
ESR-mediated signaling	TAS	Reactome
Estrogen-dependent gene expression	TAS	Reactome
Factors involved in megakaryocyte development and platelet production	TAS	Reactome
HDACs deacetylate histones	TAS	Reactome
HDMs demethylate histones	TAS	Reactome
Hemostasis	TAS	Reactome
Infectious disease	TAS	Reactome
Intracellular signaling by second messengers	IEA	Reactome
NR1H2 and NR1H3-mediated signaling	TAS	Reactome
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	TAS	Reactome
PIP3 activates AKT signaling	IEA	Reactome
Potential therapeutics for SARS	TAS	Reactome
PTEN Regulation	IEA	Reactome
Regulation of PTEN gene transcription	IEA	Reactome
RHO GTPase Effectors	TAS	Reactome
RHO GTPases activate PKNs	TAS	Reactome
SARS-CoV Infections	TAS	Reactome
Signal Transduction	IEA	Reactome
Signal Transduction	TAS	Reactome
Signaling by Nuclear Receptors	TAS	Reactome
Signaling by Rho GTPases	TAS	Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	TAS	Reactome
Viral Infection Pathways	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here