Gene description for PPP2CB
Gene name protein phosphatase 2, catalytic subunit, beta isozyme
Gene symbol PPP2CB
Other names/aliases PP2Abeta
PP2CB
Species Homo sapiens
 Database cross references - PPP2CB
ExoCarta ExoCarta_5516
Vesiclepedia VP_5516
Entrez Gene 5516
HGNC 9300
MIM 176916
UniProt P62714  
 PPP2CB identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for PPP2CB
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IBA
    protein serine/threonine phosphatase activity GO:0004722 ISS
    protein serine/threonine phosphatase activity GO:0004722 TAS
    protein binding GO:0005515 IPI
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    transmembrane transporter binding GO:0044325 IEA
    metal ion binding GO:0046872 IEA
    tau protein binding GO:0048156 NAS
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    mitotic cell cycle GO:0000278 IBA
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein dephosphorylation GO:0006470 TAS
    apoptotic mitochondrial changes GO:0008637 IEA
    response to lead ion GO:0010288 ISS
    negative regulation of gene expression GO:0010629 IGI
    negative regulation of gene expression GO:0010629 IMP
    negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IGI
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IGI
    response to endoplasmic reticulum stress GO:0034976 IEA
    peptidyl-threonine dephosphorylation GO:0035970 TAS
    response to hydrogen peroxide GO:0042542 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    negative regulation of Ras protein signal transduction GO:0046580 IEA
    response to antibiotic GO:0046677 IEA
    peptidyl-serine dephosphorylation GO:0070262 TAS
    positive regulation of microtubule binding GO:1904528 ISS
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 TAS
    chromosome, centromeric region GO:0000775 IEA
    spindle pole GO:0000922 IEA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    FAR/SIN/STRIPAK complex GO:0090443 IDA
 Experiment description of studies that identified PPP2CB in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2CB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 INTS4  
Affinity Capture-MS Homo sapiens
3 ENSA 2029
Affinity Capture-MS Homo sapiens
4 Sgol2  
Affinity Capture-MS Mus musculus
5 ANKLE2 23141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PPP2R4 5524
Affinity Capture-MS Homo sapiens
7 STK25 10494
Affinity Capture-MS Homo sapiens
8 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TBC1D4  
Affinity Capture-MS Homo sapiens
10 PPP2R3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TBCCD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SIKE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PSMA4 5685
Co-fractionation Homo sapiens
14 PSMD11 5717
Co-fractionation Homo sapiens
15 HK3  
Two-hybrid Homo sapiens
16 STRN3 29966
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GSTA1 2938
Two-hybrid Homo sapiens
18 TAB1 10454
Two-hybrid Homo sapiens
19 MAP4K4 9448
Affinity Capture-MS Homo sapiens
20 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 INTS1 26173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HMGCS1 3157
Co-fractionation Homo sapiens
23 INTS9 55756
Affinity Capture-MS Homo sapiens
24 RNH1 6050
Co-fractionation Homo sapiens
25 PDCD10 11235
Affinity Capture-MS Homo sapiens
26 TCTEX1D2  
Two-hybrid Homo sapiens
27 PPP2R1B 5519
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 DECR2 26063
Affinity Capture-MS Homo sapiens
29 STRN 6801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PLXNA3 55558
Two-hybrid Homo sapiens
31 PPFIA3 8541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TMEM41B 440026
Affinity Capture-MS Homo sapiens
34 PPP2R5C 5527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PPP4R1 9989
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 Fgfr1op  
Affinity Capture-MS Mus musculus
37 WDR12 55759
Co-fractionation Homo sapiens
38 RECQL4  
Affinity Capture-MS Homo sapiens
39 MARCH5  
Affinity Capture-MS Homo sapiens
40 PSMC2 5701
Co-fractionation Homo sapiens
41 CCDC6 8030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ADARB1 104
Affinity Capture-MS Homo sapiens
43 DYNLL1 8655
Affinity Capture-MS Homo sapiens
44 ITGA4 3676
Affinity Capture-MS Homo sapiens
45 CCDC61  
Affinity Capture-MS Homo sapiens
46 INTS6 26512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 NDUFAF1  
Affinity Capture-MS Homo sapiens
48 STRIP1 85369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 FOXD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 MARK4  
Affinity Capture-MS Homo sapiens
51 INTS12  
Affinity Capture-MS Homo sapiens
52 PKN3 29941
Affinity Capture-MS Homo sapiens
53 MYLPF 29895
Affinity Capture-MS Homo sapiens
54 CTTNBP2NL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CEP131 22994
Affinity Capture-MS Homo sapiens
56 NIF3L1 60491
Co-fractionation Homo sapiens
57 PSMC3 5702
Co-fractionation Homo sapiens
58 SERTAD2 9792
Affinity Capture-MS Homo sapiens
59 HSPA8 3312
Cross-Linking-MS (XL-MS) Homo sapiens
60 OTUD1 220213
Affinity Capture-MS Homo sapiens
61 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SERTAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 AURKA 6790
Affinity Capture-MS Homo sapiens
64 NSUN2 54888
Co-fractionation Homo sapiens
65 CDK16 5127
Affinity Capture-MS Homo sapiens
66 TCP1 6950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 FOXC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 BHLHE41  
Two-hybrid Homo sapiens
69 ZNF444  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 CRY1  
Affinity Capture-MS Homo sapiens
71 MOB4 25843
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TGM2 7052
Co-fractionation Homo sapiens
73 PARK2  
Affinity Capture-MS Homo sapiens
74 FAM122A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 SUPT5H 6829
Affinity Capture-MS Homo sapiens
76 SNAI2  
Affinity Capture-MS Homo sapiens
77 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 WDR61 80349
Affinity Capture-MS Homo sapiens
79 ESRRB  
Affinity Capture-MS Homo sapiens
80 PPP2R5B 5526
Affinity Capture-MS Homo sapiens
81 ACP5  
Two-hybrid Homo sapiens
82 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CBX5 23468
Affinity Capture-MS Homo sapiens
84 TAB2  
Two-hybrid Homo sapiens
85 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
86 PPP2R3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 CRY2  
Affinity Capture-MS Homo sapiens
88 MYH10 4628
Affinity Capture-MS Homo sapiens
89 DYNLL2 140735
Affinity Capture-MS Homo sapiens
90 ATG7 10533
Co-fractionation Homo sapiens
91 HDAC5 10014
Affinity Capture-MS Homo sapiens
92 Ppp2r2d  
Affinity Capture-MS Mus musculus
93 FGFR1OP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 C22orf39  
Two-hybrid Homo sapiens
95 IGBP1 3476
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 CDK17 5128
Affinity Capture-MS Homo sapiens
97 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
98 C16orf72 29035
Affinity Capture-MS Homo sapiens
99 ASB5  
Affinity Capture-MS Homo sapiens
100 MAPT  
Biochemical Activity Homo sapiens
101 Strn3  
Affinity Capture-MS Mus musculus
102 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 MAP7 9053
Affinity Capture-MS Homo sapiens
104 PSMB6 5694
Co-fractionation Homo sapiens
105 MAK  
Two-hybrid Homo sapiens
106 NOSIP 51070
Affinity Capture-MS Homo sapiens
107 TIPRL 261726
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
108 ZFP28  
Two-hybrid Homo sapiens
109 DOCK7 85440
Two-hybrid Homo sapiens
110 PFDN2 5202
Affinity Capture-MS Homo sapiens
111 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 CAMSAP3  
Affinity Capture-MS Homo sapiens
113 ACTBL2 345651
Affinity Capture-MS Homo sapiens
114 SGOL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 Fbxl16  
Affinity Capture-MS Mus musculus
116 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
117 ELAC2 60528
Co-fractionation Homo sapiens
118 HR  
Affinity Capture-MS Homo sapiens
119 MARK3 4140
Affinity Capture-MS Homo sapiens
120 IER2 9592
Affinity Capture-MS Homo sapiens
121 VBP1 7411
Affinity Capture-MS Homo sapiens
122 PLEKHA5 54477
Affinity Capture-MS Homo sapiens
123 PRKCI 5584
Co-fractionation Homo sapiens
124 PFDN6 10471
Affinity Capture-MS Homo sapiens
125 FAM122B  
Affinity Capture-MS Homo sapiens
126 FOXO3  
Affinity Capture-MS Homo sapiens
127 PPP2R1A 5518
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
128 BAG1 573
Affinity Capture-MS Homo sapiens
129 SET 6418
Affinity Capture-MS Homo sapiens
130 CCT8 10694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 PTPDC1  
Affinity Capture-MS Homo sapiens
132 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
133 TTC1 7265
Co-fractionation Homo sapiens
134 RAF1 5894
Two-hybrid Homo sapiens
135 RPLP1 6176
Two-hybrid Homo sapiens
136 Dynll1 56455
Affinity Capture-MS Mus musculus
137 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 FSCN1 6624
Affinity Capture-MS Homo sapiens
139 CEP350 9857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 PPFIA1 8500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 INTS5 80789
Affinity Capture-MS Homo sapiens
142 PFDN5 5204
Affinity Capture-MS Homo sapiens
143 PPME1 51400
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 PRR14L 253143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 TLX1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
146 RELA 5970
Reconstituted Complex Homo sapiens
147 CPSF3L 54973
Affinity Capture-MS Homo sapiens
148 ARL2 402
Co-purification Homo sapiens
149 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
150 PPP4C 5531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 CDC20 991
Affinity Capture-MS Homo sapiens
154 CDCA4 55038
Affinity Capture-MS Homo sapiens
155 SLMAP 7871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 ZFP36  
Affinity Capture-RNA Homo sapiens
157 TTC33  
Affinity Capture-MS Homo sapiens
158 STRIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 STRN4 29888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 FBXL16  
Affinity Capture-MS Homo sapiens
162 CEP72  
Affinity Capture-MS Homo sapiens
163 SMEK2  
Affinity Capture-MS Homo sapiens
164 CDK18 5129
Affinity Capture-MS Homo sapiens
165 TRMT61B  
Two-hybrid Homo sapiens
166 SQSTM1 8878
Proximity Label-MS Homo sapiens
167 INTS2  
Affinity Capture-MS Homo sapiens
168 PPP2R2C 5522
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 STK26 51765
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 PRR14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 MYL12A 10627
Co-fractionation Homo sapiens
172 AARSD1 80755
Co-fractionation Homo sapiens
173 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 TERF1 7013
Affinity Capture-MS Homo sapiens
176 IK 3550
Affinity Capture-MS Homo sapiens
177 GAPDH 2597
Cross-Linking-MS (XL-MS) Homo sapiens
178 FGFR1OP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 PSMA7 5688
Co-fractionation Homo sapiens
180 CTTNBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 FECH 2235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 SERBP1 26135
Affinity Capture-MS Homo sapiens
183 INTS3 65123
Affinity Capture-MS Homo sapiens
184 C9orf72  
Affinity Capture-MS Homo sapiens
185 SSRP1 6749
Affinity Capture-MS Homo sapiens
186 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 NOTCH1 4851
Affinity Capture-Western Homo sapiens
188 ZNF775  
Two-hybrid Homo sapiens
189 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPP2CB is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal TAS Reactome
Amplification of signal from the kinetochores TAS Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
APC truncation mutants have impaired AXIN binding TAS Reactome
AXIN missense mutants destabilize the destruction complex TAS Reactome
Beta-catenin phosphorylation cascade TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cell Cycle, Mitotic IEA Reactome
Costimulation by the CD28 family TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
CTNNB1 S33 mutants aren't phosphorylated TAS Reactome
CTNNB1 S37 mutants aren't phosphorylated TAS Reactome
CTNNB1 S45 mutants aren't phosphorylated TAS Reactome
CTNNB1 T41 mutants aren't phosphorylated TAS Reactome
Cyclin A/B1/B2 associated events during G2/M transition TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DARPP-32 events TAS Reactome
Degradation of beta-catenin by the destruction complex TAS Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane TAS Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
E2F mediated regulation of DNA replication TAS Reactome
EML4 and NUDC in mitotic spindle formation TAS Reactome
ERK/MAPK targets TAS Reactome
ERKs are inactivated TAS Reactome
G alpha (i) signalling events TAS Reactome
G1 Phase TAS Reactome
G1/S Transition TAS Reactome
G2/M Transition TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Glucose metabolism IEA Reactome
Glycolysis IEA Reactome
GPCR downstream signalling TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Inhibition of replication initiation of damaged DNA by RB1/E2F1 TAS Reactome
Innate Immune System TAS Reactome
Integration of energy metabolism IEA Reactome
Interferon Signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
M Phase TAS Reactome
M Phase IEA Reactome
MAP kinase activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MASTL Facilitates Mitotic Progression IEA Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome
Mitotic Anaphase TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Mitotic G2-G2/M phases TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Prometaphase TAS Reactome
Mitotic Prophase IEA Reactome
Mitotic Spindle Checkpoint TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Negative regulation of FGFR1 signaling TAS Reactome
Negative regulation of FGFR2 signaling TAS Reactome
Negative regulation of FGFR3 signaling TAS Reactome
Negative regulation of FGFR4 signaling TAS Reactome
Negative regulation of MAPK pathway TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nuclear Events (kinase and transcription factor activation) TAS Reactome
Opioid Signalling TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
PKR-mediated signaling TAS Reactome
Platelet homeostasis TAS Reactome
Platelet sensitization by LDL TAS Reactome
PP2A-mediated dephosphorylation of key metabolic factors IEA Reactome
RAF activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism IEA Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Degradation TAS Reactome
Regulation of TP53 Expression and Degradation TAS Reactome
Resolution of Sister Chromatid Cohesion TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate Formins TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by AMER1 mutants TAS Reactome
Signaling by APC mutants TAS Reactome
Signaling by AXIN mutants TAS Reactome
Signaling by CTNNB1 phospho-site mutants TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by GSK3beta mutants TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRKs TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT in cancer TAS Reactome
Spry regulation of FGF signaling TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Truncations of AMER1 destabilize the destruction complex TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here