Gene description for ZNF451
Gene name zinc finger protein 451
Gene symbol ZNF451
Other names/aliases COASTER
dJ417I1.1
Species Homo sapiens
 Database cross references - ZNF451
ExoCarta ExoCarta_26036
Entrez Gene 26036
HGNC 21091
MIM 615708
UniProt Q9Y4E5  
 ZNF451 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ZNF451
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified ZNF451 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ZNF451
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2I 7329
Two-hybrid Homo sapiens
2 RNF40 9810
Two-hybrid Homo sapiens
3 SNIP1  
Affinity Capture-MS Homo sapiens
4 RAP1GDS1 5910
Two-hybrid Homo sapiens
5 FXR2 9513
Two-hybrid Homo sapiens
6 NDP52  
Two-hybrid Homo sapiens
7 PRPF40A 55660
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF451 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here