Gene description for LOXL4
Gene name lysyl oxidase-like 4
Gene symbol LOXL4
Other names/aliases LOXC
Species Homo sapiens
 Database cross references - LOXL4
ExoCarta ExoCarta_84171
Entrez Gene 84171
HGNC 17171
MIM 607318
UniProt Q96JB6  
 LOXL4 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for LOXL4
Molecular Function
    protein-lysine 6-oxidase activity GO:0004720 IEA
    copper ion binding GO:0005507 IEA
    scavenger receptor activity GO:0005044 IEA
    protein binding GO:0005515 IPI
Biological Process
    receptor-mediated endocytosis GO:0006898 IEA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    receptor complex GO:0043235 IDA
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified LOXL4 in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for LOXL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP13 9319
Two-hybrid Homo sapiens
2 COL2A1 1280
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LOXL4 is involved
PathwayEvidenceSource
Crosslinking of collagen fibrils TAS Reactome
Elastic fibre formation TAS Reactome





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