Gene description for NAV1
Gene name neuron navigator 1
Gene symbol NAV1
Other names/aliases POMFIL3
STEERIN1
UNC53H1
Species Homo sapiens
 Database cross references - NAV1
ExoCarta ExoCarta_89796
Vesiclepedia VP_89796
Entrez Gene 89796
HGNC 15989
MIM 611628
UniProt Q8NEY1  
 NAV1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for NAV1
Molecular Function
    protein binding GO:0005515 IPI
    ATP hydrolysis activity GO:0016887 IEA
Biological Process
    microtubule bundle formation GO:0001578 IBA
    neuron migration GO:0001764 IBA
    nervous system development GO:0007399 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    microtubule GO:0005874 IEA
    microtubule cytoskeleton GO:0015630 IBA
    axon initial segment GO:0043194 IBA
 Experiment description of studies that identified NAV1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NAV1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC4  
Affinity Capture-MS Homo sapiens
2 AP2B1 163
Proximity Label-MS Homo sapiens
3 Kif1b  
Affinity Capture-MS Mus musculus
4 GPR45  
Affinity Capture-MS Homo sapiens
5 BLOC1S6  
Affinity Capture-MS Homo sapiens
6 KSR1  
Affinity Capture-MS Homo sapiens
7 GIGYF2 26058
Affinity Capture-MS Homo sapiens
8 PDCD1  
Affinity Capture-MS Homo sapiens
9 APC  
Two-hybrid Homo sapiens
10 DISC1 27185
Affinity Capture-MS Homo sapiens
11 FPR1  
Affinity Capture-MS Homo sapiens
12 CDC25B 994
Affinity Capture-MS Homo sapiens
13 SRGAP2 23380
Affinity Capture-MS Homo sapiens
14 CBY1  
Affinity Capture-MS Homo sapiens
15 STX4 6810
Proximity Label-MS Homo sapiens
16 EIF4E2  
Affinity Capture-MS Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 KIF13B 23303
Affinity Capture-MS Homo sapiens
19 ZBTB21  
Affinity Capture-MS Homo sapiens
20 ZNF638 27332
Affinity Capture-MS Homo sapiens
21 DDIT4L  
Two-hybrid Homo sapiens
22 CCDC53 51019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 Cenpe  
Affinity Capture-MS Mus musculus
25 KRT31 3881
Two-hybrid Homo sapiens
26 VAPB 9217
Affinity Capture-MS Homo sapiens
27 RCC1 1104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 LRFN1  
Affinity Capture-MS Homo sapiens
30 AMOT  
Proximity Label-MS Homo sapiens
31 GPR17 2840
Affinity Capture-MS Homo sapiens
32 KIF14 9928
Affinity Capture-MS Homo sapiens
33 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MAPK1 5594
Affinity Capture-MS Homo sapiens
35 PFN1 5216
Proximity Label-MS Homo sapiens
36 KRT8 3856
Proximity Label-MS Homo sapiens
37 RNF41  
Affinity Capture-MS Homo sapiens
38 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
39 TESK2  
Affinity Capture-MS Homo sapiens
40 MAPRE1 22919
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 RSRC2  
Two-hybrid Homo sapiens
43 TBC1D32 221322
Proximity Label-MS Homo sapiens
44 CCNB1 891
Negative Genetic Homo sapiens
45 GCC1 79571
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 BACE2 25825
Affinity Capture-MS Homo sapiens
47 GPR182  
Affinity Capture-MS Homo sapiens
48 DCTN1 1639
Proximity Label-MS Homo sapiens
49 PEX14 5195
Proximity Label-MS Homo sapiens
50 PPA2 27068
Co-fractionation Homo sapiens
51 MEX3A  
Affinity Capture-RNA Homo sapiens
52 KCTD3  
Affinity Capture-MS Homo sapiens
53 RHOT2 89941
Proximity Label-MS Homo sapiens
54 UBXN6 80700
Affinity Capture-MS Homo sapiens
55 LIMA1 51474
Affinity Capture-MS Homo sapiens
56 APLNR  
Affinity Capture-MS Homo sapiens
57 DCLK1 9201
Affinity Capture-MS Homo sapiens
58 CANX 821
Cross-Linking-MS (XL-MS) Homo sapiens
59 NUP62CL  
Affinity Capture-MS Homo sapiens
60 PPA1 5464
Co-fractionation Homo sapiens
61 PTH2R  
Affinity Capture-MS Homo sapiens
62 INPP5E 56623
Affinity Capture-MS Homo sapiens
63 TRIO 7204
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
64 FKBP8 23770
Proximity Label-MS Homo sapiens
65 NADK 65220
Affinity Capture-MS Homo sapiens
66 METTL21B  
Affinity Capture-MS Homo sapiens
67 OPRL1 4987
Affinity Capture-MS Homo sapiens
68 DUSP16  
Affinity Capture-MS Homo sapiens
69 KRT27 342574
Affinity Capture-MS Homo sapiens
70 MAPRE3  
Proximity Label-MS Homo sapiens
71 COG6 57511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 C12orf74  
Affinity Capture-MS Homo sapiens
73 RPA3 6119
Proximity Label-MS Homo sapiens
74 GIGYF1  
Affinity Capture-MS Homo sapiens
75 GOLGA1  
Proximity Label-MS Homo sapiens
76 NDC80 10403
Proximity Label-MS Homo sapiens
77 CGN  
Affinity Capture-MS Homo sapiens
78 P2RY10  
Affinity Capture-MS Homo sapiens
79 PCM1 5108
Proximity Label-MS Homo sapiens
80 MAGEA8  
Affinity Capture-MS Homo sapiens
81 DENND4C 55667
Affinity Capture-MS Homo sapiens
82 MAP3K14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 FBXW11  
Affinity Capture-MS Homo sapiens
84 SYDE1 85360
Affinity Capture-MS Homo sapiens
85 COPZ1 22818
Affinity Capture-MS Homo sapiens
86 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
87 PRKY  
Affinity Capture-MS Homo sapiens
88 RTKN 6242
Affinity Capture-MS Homo sapiens
89 DENND1A 57706
Affinity Capture-MS Homo sapiens
90 MFSD4  
Affinity Capture-MS Homo sapiens
91 PPM1H  
Affinity Capture-MS Homo sapiens
92 SRSF12  
Affinity Capture-MS Homo sapiens
93 LCK 3932
Proximity Label-MS Homo sapiens
94 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
95 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
96 CDC25C  
Affinity Capture-MS Homo sapiens
97 PRIMPOL  
Two-hybrid Homo sapiens
98 KIFAP3 22920
Two-hybrid Homo sapiens
99 AGAP1  
Affinity Capture-MS Homo sapiens
100 BRK1 55845
Affinity Capture-MS Homo sapiens
101 CD80 941
Affinity Capture-MS Homo sapiens
102 NF1 4763
Affinity Capture-MS Homo sapiens
103 TRIM37  
Proximity Label-MS Homo sapiens
104 KDM1A 23028
Proximity Label-MS Homo sapiens
105 EEF1A1P5 158078
Cross-Linking-MS (XL-MS) Homo sapiens
106 KRT38 8687
Affinity Capture-MS Homo sapiens
107 CEP135  
Proximity Label-MS Homo sapiens
108 MAST3  
Affinity Capture-MS Homo sapiens
109 CCT8L2  
Affinity Capture-MS Homo sapiens
110 MAGI1  
Affinity Capture-MS Homo sapiens
111 C17orf59 54785
Proximity Label-MS Homo sapiens
112 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NAV1 is involved
No pathways found





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