Gene description for GDF9
Gene name growth differentiation factor 9
Gene symbol GDF9
Other names/aliases -
Species Homo sapiens
 Database cross references - GDF9
ExoCarta ExoCarta_2661
Vesiclepedia VP_2661
Entrez Gene 2661
HGNC 4224
MIM 601918
UniProt O60383  
 GDF9 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF9
Molecular Function
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    oocyte growth GO:0001555 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    female gamete generation GO:0007292 TAS
    positive regulation of cell population proliferation GO:0008284 IDA
    negative regulation of cell growth GO:0030308 IEA
    regulation of progesterone secretion GO:2000870 IDA
    regulation of progesterone secretion GO:2000870 IMP
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified GDF9 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
2 DLEU1  
Two-hybrid Homo sapiens
3 MYCBP 26292
Two-hybrid Homo sapiens
4 MPHOSPH6 10200
Two-hybrid Homo sapiens
5 PCDHGA6 56109
Affinity Capture-MS Homo sapiens
6 SNRPG 6637
Two-hybrid Homo sapiens
7 SMN1 6606
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 ILF3 3609
Two-hybrid Homo sapiens
9 TK1 7083
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 PAFAH1B3 5050
Two-hybrid Homo sapiens
11 SERPINB9 5272
Two-hybrid Homo sapiens
12 PSMD11 5717
Two-hybrid Homo sapiens
13 STRN4 29888
Two-hybrid Homo sapiens
14 ANXA7 310
Two-hybrid Homo sapiens
15 AP5B1 91056
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CRELD1 78987
Two-hybrid Homo sapiens
18 FOXG1  
Two-hybrid Homo sapiens
19 TUBB3 10381
Affinity Capture-MS Homo sapiens
20 FXYD6  
Two-hybrid Homo sapiens
21 MOB4 25843
Two-hybrid Homo sapiens
22 CDKN1A  
Two-hybrid Homo sapiens
23 MED20 9477
Affinity Capture-MS Homo sapiens
24 APBB1  
Affinity Capture-MS Homo sapiens
25 VWA1 64856
Affinity Capture-MS Homo sapiens
26 PMF1  
Two-hybrid Homo sapiens
27 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ZNF691  
Affinity Capture-MS Homo sapiens
29 BTBD2  
Two-hybrid Homo sapiens
30 NDUFB9 4715
Two-hybrid Homo sapiens
31 ORAI2  
Two-hybrid Homo sapiens
32 KDM1A 23028
Two-hybrid Homo sapiens
33 PRKRA 8575
Two-hybrid Homo sapiens
34 LSM3 27258
Two-hybrid Homo sapiens
35 KIF22  
Two-hybrid Homo sapiens
36 FBXO2 26232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 VWDE  
Affinity Capture-MS Homo sapiens
38 PCYT2 5833
Two-hybrid Homo sapiens
39 S100A8 6279
Two-hybrid Homo sapiens
40 TRIB3  
Two-hybrid Homo sapiens
41 PCDHA4 56144
Two-hybrid Homo sapiens
42 BMPR2 659
Reconstituted Complex Homo sapiens
43 APLP1 333
Two-hybrid Homo sapiens
44 TDGF1  
Two-hybrid Homo sapiens
45 CCDC53 51019
Two-hybrid Homo sapiens
46 DNM2 1785
Two-hybrid Homo sapiens
47 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SAT1  
Two-hybrid Homo sapiens
49 RSRC1  
Two-hybrid Homo sapiens
50 GADD45G  
Two-hybrid Homo sapiens
51 HSPG2 3339
Affinity Capture-MS Homo sapiens
52 RAB27A 5873
Two-hybrid Homo sapiens
53 CDKN2C  
Two-hybrid Homo sapiens
54 MYH11 4629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 GNB2 2783
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GDF9 is involved
No pathways found





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