ExoCarta: Gene summary

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Gene description for SMARCA2
Gene name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene symbol	SMARCA2
Other names/aliases	BAF190 BRM NCBRS SNF2 SNF2L2 SNF2LA SWI2 Sth1p hBRM hSNF2a
Species	Homo sapiens
Database cross references - SMARCA2
ExoCarta	ExoCarta_6595
Vesiclepedia	VP_6595
Entrez Gene	6595
HGNC	11098
MIM	600014
UniProt	P51531
SMARCA2 identified in sEVs derived from the following tissue/cell type
Chondrocytes	35931686
Chondrocytes	35931686

Gene ontology annotations for SMARCA2

Molecular Function
	transcription cis-regulatory region binding	GO:0000976	IDA
	DNA binding	GO:0003677	IBA
	chromatin binding	GO:0003682	IBA
	transcription coactivator activity	GO:0003713	IDA
	helicase activity	GO:0004386	IEA
	protein binding	GO:0005515	IPI
	ATP binding	GO:0005524	IEA
	ATP-dependent activity, acting on DNA	GO:0008094	TAS
	hydrolase activity	GO:0016787	IEA
	histone binding	GO:0042393	IEA
	nucleosome array spacer activity	GO:0140750	IBA
Biological Process
	negative regulation of transcription by RNA polymerase II	GO:0000122	TAS
	chromatin remodeling	GO:0006338	NAS
	chromatin remodeling	GO:0006338	TAS
	regulation of DNA-templated transcription	GO:0006355	TAS
	regulation of transcription by RNA polymerase II	GO:0006357	NAS
	spermatid development	GO:0007286	IEA
	nervous system development	GO:0007399	IEA
	positive regulation of cell population proliferation	GO:0008284	NAS
	negative regulation of cell population proliferation	GO:0008285	IDA
	regulation of mitotic metaphase/anaphase transition	GO:0030071	NAS
	negative regulation of cell growth	GO:0030308	IMP
	heterochromatin formation	GO:0031507	IBA
	positive regulation of T cell differentiation	GO:0045582	NAS
	negative regulation of cell differentiation	GO:0045596	NAS
	positive regulation of cell differentiation	GO:0045597	NAS
	positive regulation of myoblast differentiation	GO:0045663	NAS
	negative regulation of DNA-templated transcription	GO:0045892	IDA
	positive regulation of DNA-templated transcription	GO:0045893	IDA
	positive regulation of DNA-templated transcription	GO:0045893	IMP
	positive regulation of transcription by RNA polymerase II	GO:0045944	IBA
	positive regulation of transcription by RNA polymerase II	GO:0045944	IDA
	positive regulation of transcription by RNA polymerase II	GO:0045944	TAS
	regulation of G0 to G1 transition	GO:0070316	NAS
	positive regulation of stem cell population maintenance	GO:1902459	NAS
	regulation of G1/S transition of mitotic cell cycle	GO:2000045	NAS
	positive regulation of double-strand break repair	GO:2000781	NAS
	regulation of nucleotide-excision repair	GO:2000819	NAS
Subcellular Localization
	chromatin	GO:0000785	IBA
	chromatin	GO:0000785	IDA
	chromatin	GO:0000785	NAS
	nucleus	GO:0005634	IBA
	nucleus	GO:0005634	IDA
	nucleoplasm	GO:0005654	IDA
	nucleoplasm	GO:0005654	TAS
	SWI/SNF complex	GO:0016514	IDA
	brahma complex	GO:0035060	NAS
	intracellular membrane-bounded organelle	GO:0043231	IDA
	intermediate filament cytoskeleton	GO:0045111	IDA
	npBAF complex	GO:0071564	ISS
	npBAF complex	GO:0071564	NAS
	nBAF complex	GO:0071565	ISS
	nBAF complex	GO:0071565	NAS
	bBAF complex	GO:0140092	NAS
	GBAF complex	GO:0140288	NAS

Experiment description of studies that identified SMARCA2 in sEVs

Experiment ID

497

MISEV standards
✘	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

"Varela-EirÃn M, Carpintero-FernÃ¡ndez P, GuitiÃ¡n-CaamaÃ±o A, Varela-VÃ¡zquez A, GarcÃa-Yuste A, SÃ¡nchez-Temprano A, Bravo-LÃ³pez SB, YaÃ±ez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, MayÃ¡n MD."

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

498

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for SMARCA2

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

SEC22B

9554

Co-fractionation

Homo sapiens

GATA1

Proximity Label-MS

Homo sapiens

KIF9

64147

Cross-Linking-MS (XL-MS)

Homo sapiens

SLFN11

91607

Affinity Capture-MS

Homo sapiens

GTF2F1

2962

Co-fractionation

Homo sapiens

SMC3

9126

Co-fractionation

Homo sapiens

MCM8

84515

Affinity Capture-MS

Homo sapiens

CBX1

10951

Affinity Capture-MS

Homo sapiens

GMNN

Affinity Capture-Western

Homo sapiens

TAF1

Affinity Capture-Western

Homo sapiens

HDAC2

3066

Co-purification		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

ELF1

1997

Proximity Label-MS

Homo sapiens

IRF4

Proximity Label-MS

Homo sapiens

GLTSCR1L

Affinity Capture-MS

Homo sapiens

ADCK3

Affinity Capture-MS

Homo sapiens

KPNA1

3836

Affinity Capture-MS

Homo sapiens

MYL6

4637

Affinity Capture-MS

Homo sapiens

TOP2B

7155

Co-fractionation

Homo sapiens

Bcl7b

Affinity Capture-MS

Mus musculus

LHX2

Proximity Label-MS

Homo sapiens

GATA2

Proximity Label-MS

Homo sapiens

ACTC1

Affinity Capture-MS

Homo sapiens

NOP56

10528

Co-fractionation

Homo sapiens

TEKT1

Affinity Capture-MS

Homo sapiens

SMARCE1

6605

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KIF20A

10112

Affinity Capture-MS

Homo sapiens

BRD2

Affinity Capture-MS

Homo sapiens

PPIA

5478

Affinity Capture-MS

Homo sapiens

KPNA2

3838

Affinity Capture-MS

Homo sapiens

SAP30

8819

Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens

SMARCD2

6603

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

SOX10

Proximity Label-MS

Homo sapiens

ELF4

2000

Proximity Label-MS

Homo sapiens

CMBL

134147

Affinity Capture-MS

Homo sapiens

CENPA

Proximity Label-MS

Homo sapiens

IL21R

Affinity Capture-MS

Homo sapiens

DPF1

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HSPA4

3308

Cross-Linking-MS (XL-MS)

Homo sapiens

RUVBL1

8607

Co-fractionation

Homo sapiens

NCOR1

Co-fractionation

Homo sapiens

TAF9

6880

Affinity Capture-Western

Homo sapiens

BCL7B

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

Actl6a

Affinity Capture-Western

Mus musculus

NONO

4841

Affinity Capture-Western

Homo sapiens

ACTR3

10096

Proximity Label-MS

Homo sapiens

ACTL6B

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

NUP35

129401

Proximity Label-MS

Homo sapiens

CHMP2A

27243

Affinity Capture-MS

Homo sapiens

KHDRBS1

10657

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

REV3L

Affinity Capture-MS

Homo sapiens

GCM1

Proximity Label-MS

Homo sapiens

KHSRP

8570

Co-fractionation

Homo sapiens

TEAD1

Proximity Label-MS

Homo sapiens

BMI1

Affinity Capture-MS

Homo sapiens

SCN5A

6331

Affinity Capture-MS

Homo sapiens

EED

Affinity Capture-MS

Homo sapiens

KLF4

Proximity Label-MS

Homo sapiens

TPRN

286262

Affinity Capture-MS

Homo sapiens

PHB

5245

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

SLC35G1

Affinity Capture-MS

Homo sapiens

LHX4

Proximity Label-MS

Homo sapiens

MECP2

4204

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

TLX3

Proximity Label-MS

Homo sapiens

UBE2H

7328

Affinity Capture-MS

Homo sapiens

MYCN

Affinity Capture-MS

Homo sapiens

SDCBP

6386

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

CHD3

1107

Affinity Capture-Western

Homo sapiens

SMARCB1

6598

Co-purification		Homo sapiens
Co-purification		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Cross-Linking-MS (XL-MS)		Homo sapiens

NFIB

Proximity Label-MS

Homo sapiens

MTA2

9219

Co-fractionation

Homo sapiens

KIF14

9928

Affinity Capture-MS

Homo sapiens

Cebpb

Affinity Capture-Western

Rattus norvegicus

FOXP1

27086

Protein-RNA

Homo sapiens

Actl6b

Affinity Capture-Western

Mus musculus

RAN

5901

Affinity Capture-Western

Homo sapiens

PRPF6

24148

Affinity Capture-Western

Homo sapiens

PHF10

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZIC2

Affinity Capture-MS

Homo sapiens

RBBP7

5931

Affinity Capture-Western

Homo sapiens

FOXC1

Affinity Capture-MS

Homo sapiens

SPTA1

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

SOX17

Proximity Label-MS

Homo sapiens

RAD51AP1

Affinity Capture-MS

Homo sapiens

PARK2

Affinity Capture-MS

Homo sapiens

IRF1

Proximity Label-MS

Homo sapiens

TMEM59L

Affinity Capture-MS

Homo sapiens

TBR1

Proximity Label-MS

Homo sapiens

XYLB

9942

Affinity Capture-MS

Homo sapiens

SIRT7

Affinity Capture-MS

Homo sapiens

SYT7

Affinity Capture-MS

Homo sapiens

NFIX

4784

Proximity Label-MS

Homo sapiens

SSX2

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

GLTSCR1

29998

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

Smarcc1

Affinity Capture-MS

Mus musculus

SMARCA4

6597

Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Negative Genetic		Homo sapiens
Cross-Linking-MS (XL-MS)		Homo sapiens

LHX1

Proximity Label-MS

Homo sapiens

SP7

Proximity Label-MS

Homo sapiens

NFIA

4774

Proximity Label-MS

Homo sapiens

YAP1

10413

Affinity Capture-MS

Homo sapiens

100

WDR72

Affinity Capture-MS

Homo sapiens

101

BCL7C

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

102

GJD4

Affinity Capture-MS

Homo sapiens

103

DPF2

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

104

ACTL6A

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Cross-Linking-MS (XL-MS)		Homo sapiens
Co-purification		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

105

CBX5

23468

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens

106

LHX3

Proximity Label-MS

Homo sapiens

107

LHX8

Proximity Label-MS

Homo sapiens

108

RAP1A

5906

Reconstituted Complex

Homo sapiens

109

BEND7

222389

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

110

SIN3A

Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

111

CLSTN2

64084

Affinity Capture-MS

Homo sapiens

112

PAX8

Proximity Label-MS

Homo sapiens

113

BANF1

8815

Affinity Capture-MS

Homo sapiens

114

RCN2

5955

Affinity Capture-MS

Homo sapiens

115

OSMR

9180

Affinity Capture-MS

Homo sapiens

116

WHSC1L1

Affinity Capture-MS

Homo sapiens

117

NOL4

Affinity Capture-MS

Homo sapiens

118

BARD1

580

Affinity Capture-Western

Homo sapiens

119

CREBBP

Affinity Capture-Western

Homo sapiens

120

Proximity Label-MS

Homo sapiens

121

MBD3

53615

Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens

122

SS18L1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

FUBP1

8880

Co-fractionation

Homo sapiens

124

ZMYND11

10771

Affinity Capture-Western

Homo sapiens

125

DNTTIP2

Affinity Capture-MS

Homo sapiens

126

CEBPA

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Proximity Label-MS		Homo sapiens

127

BRCA1

672

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

128

SMARCC2

6601

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

129

IYD

Affinity Capture-MS

Homo sapiens

130

SQRDL

58472

Affinity Capture-MS

Homo sapiens

131

SOX7

Proximity Label-MS

Homo sapiens

132

BRD7

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

133

XIAP

Affinity Capture-MS

Homo sapiens

134

PAX6

Proximity Label-MS

Homo sapiens

135

HIST1H3A

8350

Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

136

NR4A1

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens

137

ASS1

445

Affinity Capture-MS

Homo sapiens

138

LBX1

Affinity Capture-MS

Homo sapiens

139

SLC9A3R2

9351

Co-fractionation

Homo sapiens

140

SMARCD1

6602

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

141

SMARCA5

8467

Co-fractionation

Homo sapiens

142

NR0B2

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

143

EPAS1

Affinity Capture-MS

Homo sapiens

144

PPARG

5468

Proximity Label-MS

Homo sapiens

145

AOX1

316

Affinity Capture-MS

Homo sapiens

146

CPEB4

Affinity Capture-MS

Homo sapiens

147

SREBF1

6720

Affinity Capture-Western

Homo sapiens

148

DPF3

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

149

FOXI1

Proximity Label-MS

Homo sapiens

150

ACTBL2

345651

Affinity Capture-MS

Homo sapiens

151

NR3C1

2908

Affinity Capture-Western		Homo sapiens
Proximity Label-MS		Homo sapiens

152

CCNE1

Affinity Capture-Western

Homo sapiens

153

GATA3

Proximity Label-MS

Homo sapiens

154

SEPT11

55752

Co-fractionation

Homo sapiens

155

CCNB3

Affinity Capture-MS

Homo sapiens

156

MDM4

Reconstituted Complex

Homo sapiens

157

POLR2A

5430

Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Co-purification		Homo sapiens
Co-purification		Homo sapiens
Co-localization		Homo sapiens

158

SIN3B

Reconstituted Complex

Homo sapiens

159

SS18

Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

160

ZNF212

Affinity Capture-MS

Homo sapiens

161

ARID1B

57492

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

162

HNF4A

Proximity Label-MS

Homo sapiens

163

PRMT5

10419

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

164

STAT1

6772

Affinity Capture-Western

Homo sapiens

165

MYC

Reconstituted Complex		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

166

ERG

Proximity Label-MS

Homo sapiens

167

ARHGAP4

393

Affinity Capture-MS

Homo sapiens

168

MAPK4

Affinity Capture-MS

Homo sapiens

169

OR8H2

Affinity Capture-MS

Homo sapiens

170

TMOD3

29766

Affinity Capture-MS

Homo sapiens

171

ARHGAP33

115703

Affinity Capture-MS

Homo sapiens

172

ETS1

Proximity Label-MS

Homo sapiens

173

ETV4

Proximity Label-MS

Homo sapiens

174

BAZ1A

11177

Affinity Capture-Western

Homo sapiens

175

HNF1B

Proximity Label-MS

Homo sapiens

176

ARID1A

8289

Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

177

HAX1

Affinity Capture-MS

Homo sapiens

178

JOSD2

Affinity Capture-MS

Homo sapiens

179

SOX9

Proximity Label-MS

Homo sapiens

180

MYB

Reconstituted Complex

Homo sapiens

181

BRD9

65980

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

182

BRD3

8019

Affinity Capture-MS

Homo sapiens

183

GNB2L1

10399

Affinity Capture-MS

Homo sapiens

184

MDM2

Reconstituted Complex

Homo sapiens

185

SOX2

Proximity Label-MS

Homo sapiens

186

TPM3

7170

Affinity Capture-MS

Homo sapiens

187

H2AFX

3014

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

188

HIF1A

3091

Co-localization

Homo sapiens

189

ANKRD54

Affinity Capture-MS

Homo sapiens

190

PSMB2

5690

Co-fractionation

Homo sapiens

191

TLX1

Proximity Label-MS

Homo sapiens

192

RELA

5970

Co-localization

Homo sapiens

193

TAF6

6878

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

194

MYO1C

4641

Affinity Capture-MS

Homo sapiens

195

SFPQ

6421

Affinity Capture-Western

Homo sapiens

196

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

197

SMARCD3

Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

198

SIRT6

Affinity Capture-MS

Homo sapiens

199

PARP1

142

Proximity Label-MS

Homo sapiens

200

ARID2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

201

ELF5

Proximity Label-MS

Homo sapiens

202

STK11IP

114790

Affinity Capture-MS

Homo sapiens

203

NR4A2

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

204

HMGB1

3146

Co-fractionation

Homo sapiens

205

CDK8

1024

Co-fractionation

Homo sapiens

206

ALL1

Affinity Capture-Western

Homo sapiens

207

CDA

978

Affinity Capture-MS

Homo sapiens

208

TBP

Affinity Capture-Western

Homo sapiens

209

SH3TC1

54436

Affinity Capture-MS

Homo sapiens

210

CALU

813

Affinity Capture-MS

Homo sapiens

211

POLR1C

9533

Co-fractionation

Homo sapiens

212

SMARCC1

6599

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-purification		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

213

KAT2B

Affinity Capture-Western

Homo sapiens

214

SAP18

10284

Co-fractionation

Homo sapiens

215

KLF3

Proximity Label-MS

Homo sapiens

216

HIST1H2BC

8347

Cross-Linking-MS (XL-MS)

Homo sapiens

217

TANC2

Affinity Capture-MS

Homo sapiens

218

PITX1

Reconstituted Complex

Homo sapiens

219

ZKSCAN2

Affinity Capture-MS

Homo sapiens

220

PBRM1

55193

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

221

HSPB1

3315

Two-hybrid

Homo sapiens

222

HDAC1

3065

Affinity Capture-MS		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-Western		Homo sapiens

223

CHD4

1108

Affinity Capture-MS

Homo sapiens

224

PAX9

Proximity Label-MS

Homo sapiens

225

DDX58

23586

Affinity Capture-RNA

Homo sapiens

226

MKI67

Affinity Capture-MS

Homo sapiens

227

MYOD1

Proximity Label-MS

Homo sapiens

228

ESR1

Two-hybrid

Homo sapiens

229

KLF5

Proximity Label-MS

Homo sapiens

230

WWP2

11060

Affinity Capture-MS

Homo sapiens

231

MCPH1

Affinity Capture-Western

Homo sapiens

232

PAX7

Proximity Label-MS

Homo sapiens

233

HDGFRP2

84717

Affinity Capture-MS

Homo sapiens

234

KDM1A

23028

Co-fractionation

Homo sapiens

235

H3F3A

326601

Reconstituted Complex

Bos taurus

236

EZH2

Affinity Capture-Western

Homo sapiens

237

RNASEH2A

10535

Affinity Capture-MS

Homo sapiens

238

TTC7A

57217

Affinity Capture-MS

Homo sapiens

239

ZCCHC10

Affinity Capture-MS

Homo sapiens

240

RELB

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

241

ZMAT3

Affinity Capture-MS

Homo sapiens

242

GTF2E1

2960

Co-fractionation

Homo sapiens

243

FOS

2353

Proximity Label-MS

Homo sapiens

244

CEBPB

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

245

IL16

Affinity Capture-MS

Homo sapiens

246

HIRA

Affinity Capture-Western

Homo sapiens

247

CDX2

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

248

NFIC

4782

Proximity Label-MS

Homo sapiens

249

367

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

250

SMURF2

64750

Affinity Capture-MS

Homo sapiens

251

SS18L2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

252

HMGB2

3148

Cross-Linking-MS (XL-MS)

Homo sapiens

253

VAX2

Affinity Capture-MS

Homo sapiens

254

RBBP4

5928

Co-purification		Homo sapiens
Affinity Capture-Western		Homo sapiens

255

Bcl7c

Affinity Capture-MS

Mus musculus

256

IL12RB2

Affinity Capture-MS

Homo sapiens

257

BCL7A

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

258

BCKDHA

593

Affinity Capture-MS

Homo sapiens

259

CUL4A

8451

Affinity Capture-MS

Homo sapiens

260

EP300

2033

Affinity Capture-Western

Homo sapiens

261

CDC5L

988

Affinity Capture-MS

Homo sapiens

262

NHLH1

Proximity Label-MS

Homo sapiens

263

HIST1H2BA

255626

Cross-Linking-MS (XL-MS)

Homo sapiens

View the network

Pathways in which SMARCA2 is involved

Pathway	Evidence	Source
Chromatin modifying enzymes	TAS	Reactome
Chromatin organization	TAS	Reactome
Developmental Biology	IEA	Reactome
Developmental Biology	TAS	Reactome
Epigenetic regulation of gene expression	IEA	Reactome
Gene expression (Transcription)	TAS	Reactome
Gene expression (Transcription)	IEA	Reactome
Generic Transcription Pathway	TAS	Reactome
MITF-M-dependent gene expression	IEA	Reactome
MITF-M-dependent gene expression	TAS	Reactome
MITF-M-regulated melanocyte development	IEA	Reactome
MITF-M-regulated melanocyte development	TAS	Reactome
Regulation of endogenous retroelements	IEA	Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	IEA	Reactome
Regulation of MITF-M-dependent genes involved in pigmentation	IEA	Reactome
Regulation of MITF-M-dependent genes involved in pigmentation	TAS	Reactome
RMTs methylate histone arginines	TAS	Reactome
RNA Polymerase II Transcription	TAS	Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	TAS	Reactome
Transcriptional regulation by RUNX1	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here