Gene description for PDCD5
Gene name programmed cell death 5
Gene symbol PDCD5
Other names/aliases TFAR19
Species Homo sapiens
 Database cross references - PDCD5
ExoCarta ExoCarta_9141
Entrez Gene 9141
HGNC 8764
MIM 604583
UniProt O14737  
 PDCD5 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
Prostate cancer cells 25844599    
 Gene ontology annotations for PDCD5
Molecular Function
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
    beta-tubulin binding GO:0048487 IPI
    acetyltransferase activator activity GO:0010698 IDA
    heparin binding GO:0008201 IDA
Biological Process
    negative regulation of cell proliferation GO:0008285 IMP
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IMP
    positive regulation of protein import into mitochondrial outer membrane GO:1903638 IMP
    positive regulation of release of cytochrome c from mitochondria GO:0090200 IMP
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    positive regulation of gene expression GO:0010628 IDA
    negative regulation of chaperone-mediated protein folding GO:1903645 IMP
    positive regulation of apoptotic process GO:0043065 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified PDCD5 in exosomes
1
Experiment ID 79
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 81
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PDCD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HTATIP  
Two-hybrid Homo sapiens
2 UTP14A 10813
Two-hybrid Homo sapiens
3 ACP5  
Two-hybrid Homo sapiens
4 EEF1G 1937
Two-hybrid Homo sapiens
5 KIAA1377  
Two-hybrid Homo sapiens
6 RIF1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PDCD5 is involved
No pathways found





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