Gene description for SFMBT1
Gene name Scm-like with four mbt domains 1
Gene symbol SFMBT1
Other names/aliases RU1
SFMBT
hSFMBT
Species Homo sapiens
 Database cross references - SFMBT1
ExoCarta ExoCarta_51460
Vesiclepedia VP_51460
Entrez Gene 51460
HGNC 20255
MIM 607319
UniProt Q9UHJ3  
 SFMBT1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SFMBT1
Molecular Function
    chromatin binding GO:0003682 IBA
    transcription corepressor activity GO:0003714 TAS
    protein binding GO:0005515 IPI
    histone binding GO:0042393 IBA
    histone binding GO:0042393 IDA
Biological Process
    chromatin organization GO:0006325 IEA
    spermatogenesis GO:0007283 IEA
    cell differentiation GO:0030154 IEA
    negative regulation of DNA-templated transcription GO:0045892 IBA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    negative regulation of muscle organ development GO:0048635 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified SFMBT1 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SFMBT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CALML3 810
Affinity Capture-MS Homo sapiens
2 RPS27A 6233
Affinity Capture-MS Homo sapiens
3 ACP1 52
Two-hybrid Homo sapiens
4 SERPINB4 6318
Affinity Capture-MS Homo sapiens
5 SAMD13  
Affinity Capture-MS Homo sapiens
6 RCOR3  
Affinity Capture-MS Homo sapiens
7 HIST1H3A 8350
Affinity Capture-Western Homo sapiens
8 RBPJ 3516
Affinity Capture-MS Homo sapiens
9 PTEN 5728
Affinity Capture-MS Homo sapiens
10 PHC1  
Two-hybrid Homo sapiens
11 ANXA1 301
Affinity Capture-MS Homo sapiens
12 SOX1 6656
Affinity Capture-MS Homo sapiens
13 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
14 S100A7 6278
Affinity Capture-MS Homo sapiens
15 SAMD1  
Affinity Capture-MS Homo sapiens
16 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HOXB9  
Two-hybrid Homo sapiens
18 S100A9 6280
Affinity Capture-MS Homo sapiens
19 LGALS7 3963
Affinity Capture-MS Homo sapiens
20 PSMA1 5682
Two-hybrid Homo sapiens
21 RCOR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 WWP2 11060
Biochemical Activity Homo sapiens
23 KDM1A 23028
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
24 L3MBTL3  
Affinity Capture-MS Homo sapiens
25 TUBA1B 10376
Affinity Capture-MS Homo sapiens
26 CALML5 51806
Affinity Capture-MS Homo sapiens
27 KIF22  
Affinity Capture-MS Homo sapiens
28 ZCCHC10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 SERPINB3 6317
Affinity Capture-MS Homo sapiens
30 SPRR2D  
Affinity Capture-MS Homo sapiens
31 LCN2 3934
Affinity Capture-MS Homo sapiens
32 PHC2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 SPANXN2  
Two-hybrid Homo sapiens
34 HMG20A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ZMYM2  
Affinity Capture-MS Homo sapiens
36 SRPK1 6732
Biochemical Activity Homo sapiens
37 ZNF516 9658
Affinity Capture-MS Homo sapiens
38 Sept6  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which SFMBT1 is involved
No pathways found





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