Gene description for DBF4B
Gene name DBF4 zinc finger B
Gene symbol DBF4B
Other names/aliases ASKL1
CHIFB
DRF1
ZDBF1B
Species Homo sapiens
 Database cross references - DBF4B
ExoCarta ExoCarta_80174
Entrez Gene 80174
HGNC 17883
MIM 611661
UniProt Q8NFT6  
 DBF4B identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for DBF4B
Molecular Function
    protein kinase activator activity GO:0030295 IDA
    zinc ion binding GO:0008270 IEA
    protein kinase binding GO:0019901 IPI
    nucleic acid binding GO:0003676 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of nuclear cell cycle DNA replication GO:0010571 IMP
    positive regulation of protein kinase activity GO:0045860 IDA
    positive regulation of cell proliferation GO:0008284 IMP
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IMP
    cell cycle GO:0007049 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    aggresome GO:0016235 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    nuclear chromatin GO:0000790 IDA
 Experiment description of studies that identified DBF4B in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for DBF4B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP4-12  
Two-hybrid Homo sapiens
2 CDC7  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DBF4B is involved
No pathways found





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