Gene description for E2F1
Gene name	E2F transcription factor 1
Gene symbol	E2F1
Other names/aliases	E2F-1 RBAP1 RBBP3 RBP3
Species	Homo sapiens
Database cross references - E2F1
ExoCarta	ExoCarta_1869
Entrez Gene	1869
HGNC	3113
MIM	189971
UniProt	Q01094
E2F1 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for E2F1

Molecular Function     sequence-specific DNA binding GO:0043565 ISS     core promoter binding GO:0001047 IDA     DNA binding GO:0003677 IMP     transcription factor binding GO:0008134 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 TAS     protein binding GO:0005515 IPI Biological Process     negative regulation of DNA binding GO:0043392 IDA     cellular response to hypoxia GO:0071456 IEA     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA     Notch signaling pathway GO:0007219 TAS     negative regulation of transcription, DNA-templated GO:0045892 IMP     cellular response to fatty acid GO:0071398 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     transcription, DNA-templated GO:0006351 ISS     forebrain development GO:0030900 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 IMP     negative regulation of fat cell proliferation GO:0070345 ISS     G1/S transition of mitotic cell cycle GO:0000082 TAS     anoikis GO:0043276 IEA     positive regulation of gene expression GO:0010628 IDA     lens fiber cell apoptotic process GO:1990086 IEA     positive regulation of transcription, DNA-templated GO:0045893 IMP     regulation of G1/S transition of mitotic cell cycle GO:2000045 IMP     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP     intrinsic apoptotic signaling pathway GO:0097193 TAS     negative regulation of fat cell differentiation GO:0045599 ISS     DNA damage checkpoint GO:0000077 IMP     positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 TAS     positive regulation of fibroblast proliferation GO:0048146 IMP     mRNA stabilization GO:0048255 IDA     apoptotic process GO:0006915 TAS     mitotic cell cycle GO:0000278 TAS     regulation of transcription, DNA-templated GO:0006355 IDA     spermatogenesis GO:0007283 IEA     programmed cell death GO:0012501 TAS Subcellular Localization     cytoplasm GO:0005737 IEA     Rb-E2F complex GO:0035189 IDA     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA