Gene description for CTBP2
Gene name C-terminal binding protein 2
Gene symbol CTBP2
Other names/aliases -
Species Homo sapiens
 Database cross references - CTBP2
ExoCarta ExoCarta_1488
Entrez Gene 1488
HGNC 2495
MIM 602619
UniProt P56545  
 CTBP2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CTBP2
Molecular Function
    retinoic acid receptor binding GO:0042974 IEA
    NAD binding GO:0051287 IEA
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IEA
    transcription coactivator activity GO:0003713 IEA
    transcription corepressor activity GO:0003714 IEA
    chromatin binding GO:0003682 IEA
    protein binding GO:0005515 IPI
Biological Process
    viral genome replication GO:0019079 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of retinoic acid receptor signaling pathway GO:0048386 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    negative regulation of cell proliferation GO:0008285 TAS
    positive regulation of chromatin binding GO:0035563 IEA
    white fat cell differentiation GO:0050872 ISS
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    transcriptional repressor complex GO:0017053 ISS
    synapse GO:0045202 IEA
    cell junction GO:0030054 IEA
 Experiment description of studies that identified CTBP2 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTBP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMF1  
Two-hybrid Homo sapiens
2 CBX4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 RAI2  
Two-hybrid Homo sapiens
4 NRIP1 8204
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 ZFPM2  
Invitro Homo sapiens
Invivo Homo sapiens
6 TEAD3  
Two-hybrid Homo sapiens
7 FTS  
Two-hybrid Homo sapiens
8 KLF3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 FHL3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
10 NOL4  
Two-hybrid Homo sapiens
11 BAZ2B  
Two-hybrid Homo sapiens
12 Pc1  
Two-hybrid 8355
Reconstituted Complex 8355
13 ELAC2  
Affinity Capture-MS Homo sapiens
14 KLF8  
Invitro Homo sapiens
Two-hybrid Homo sapiens
15 MDM2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 CTBP1 1487
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
17 SOX6  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
18 TGIF  
Two-hybrid Homo sapiens
19 CTBP2 1488
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CTBP2 is involved
PathwayEvidenceSource
repression of WNT target genes TAS Reactome
TCF7L2 mutants don't bind CTBP TAS Reactome





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