Gene description for STAT3
Gene name signal transducer and activator of transcription 3 (acute-phase response factor)
Gene symbol STAT3
Other names/aliases ADMIO
APRF
HIES
Species Homo sapiens
 Database cross references - STAT3
ExoCarta ExoCarta_6774
Vesiclepedia VP_6774
Entrez Gene 6774
HGNC 11364
MIM 102582
UniProt P40763  
 STAT3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Pluripotent stem cells 34108659    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for STAT3
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IMP
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IGI
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP
    DNA binding GO:0003677 ISS
    DNA-binding transcription factor activity GO:0003700 IC
    DNA-binding transcription factor activity GO:0003700 IDA
    RNA binding GO:0003723 IPI
    nuclear receptor activity GO:0004879 IDA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 ISS
    protein phosphatase binding GO:0019903 IPI
    chromatin DNA binding GO:0031490 IDA
    signaling adaptor activity GO:0035591 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    protein homodimerization activity GO:0042803 ISS
    protein dimerization activity GO:0046983 ISS
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    primary miRNA binding GO:0070878 IPI
    lncRNA binding GO:0106222 IDA
    DNA-binding transcription factor binding GO:0140297 IPI
    RNA sequestering activity GO:0140610 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    temperature homeostasis GO:0001659 ISS
    eye photoreceptor cell differentiation GO:0001754 ISS
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 ISS
    protein import into nucleus GO:0006606 IDA
    defense response GO:0006952 IBA
    inflammatory response GO:0006954 ISS
    signal transduction GO:0007165 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IGI
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IBA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 NAS
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 TAS
    nervous system development GO:0007399 TAS
    cell population proliferation GO:0008283 IEA
    negative regulation of cell population proliferation GO:0008285 IEA
    negative regulation of autophagy GO:0010507 IDA
    positive regulation of vascular endothelial growth factor production GO:0010575 IMP
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of gene expression GO:0010629 IDA
    phosphorylation GO:0016310 ISS
    cytokine-mediated signaling pathway GO:0019221 NAS
    sexual reproduction GO:0019953 ISS
    cell differentiation GO:0030154 IDA
    positive regulation of cell migration GO:0030335 IMP
    intracellular receptor signaling pathway GO:0030522 IDA
    response to estradiol GO:0032355 IDA
    positive regulation of interleukin-1 beta production GO:0032731 IGI
    positive regulation of interleukin-10 production GO:0032733 IGI
    positive regulation of interleukin-6 production GO:0032755 ISS
    positive regulation of interleukin-8 production GO:0032757 IGI
    positive regulation of tumor necrosis factor production GO:0032760 IGI
    cellular response to hormone stimulus GO:0032870 IDA
    leptin-mediated signaling pathway GO:0033210 IBA
    leptin-mediated signaling pathway GO:0033210 IDA
    somatic stem cell population maintenance GO:0035019 IEA
    interleukin-15-mediated signaling pathway GO:0035723 IDA
    interleukin-2-mediated signaling pathway GO:0038110 IDA
    interleukin-9-mediated signaling pathway GO:0038113 IDA
    interleukin-11-mediated signaling pathway GO:0038154 IDA
    interleukin-23-mediated signaling pathway GO:0038155 IDA
    regulation of multicellular organism growth GO:0040014 IEA
    regulation of cell population proliferation GO:0042127 IBA
    glucose homeostasis GO:0042593 ISS
    eating behavior GO:0042755 ISS
    mRNA transcription by RNA polymerase II GO:0042789 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISS
    response to peptide hormone GO:0043434 IBA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA
    cellular response to leptin stimulus GO:0044320 IDA
    response to leptin GO:0044321 IDA
    positive regulation of erythrocyte differentiation GO:0045648 IMP
    positive regulation of Notch signaling pathway GO:0045747 ISS
    positive regulation of angiogenesis GO:0045766 IEA
    negative regulation of glycolytic process GO:0045820 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    astrocyte differentiation GO:0048708 ISS
    negative regulation of inflammatory response GO:0050728 ISS
    regulation of cell cycle GO:0051726 IDA
    radial glial cell differentiation GO:0060019 ISS
    retinal rod cell differentiation GO:0060221 IEA
    regulation of feeding behavior GO:0060259 ISS
    growth hormone receptor signaling pathway GO:0060396 IDA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IBA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IDA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 ISS
    interleukin-6-mediated signaling pathway GO:0070102 IDA
    interleukin-6-mediated signaling pathway GO:0070102 IMP
    T-helper 17 type immune response GO:0072538 IDA
    T-helper 17 cell lineage commitment GO:0072540 ISS
    energy homeostasis GO:0097009 ISS
    cellular response to interleukin-17 GO:0097398 IEA
    cell surface receptor signaling pathway via STAT GO:0097696 IMP
    negative regulation of inflammatory response to wounding GO:0106015 IDA
    interleukin-10-mediated signaling pathway GO:0140105 IDA
    positive regulation of cytokine production involved in inflammatory response GO:1900017 IGI
    positive regulation of miRNA transcription GO:1902895 IDA
    positive regulation of metalloendopeptidase activity GO:1904685 IGI
    positive regulation of vascular endothelial cell proliferation GO:1905564 IEA
    negative regulation of primary miRNA processing GO:2000635 IMP
    negative regulation of stem cell differentiation GO:2000737 IEA
    negative regulation of neuron migration GO:2001223 IEA
Subcellular Localization
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 ISS
    RNA polymerase II transcription regulator complex GO:0090575 IBA
    RNA polymerase II transcription regulator complex GO:0090575 IC
    RNA polymerase II transcription regulator complex GO:0090575 IMP
    RNA polymerase II transcription regulator complex GO:0090575 IPI
    RNA polymerase II transcription regulator complex GO:0090575 NAS
 Experiment description of studies that identified STAT3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
10
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
22
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
25
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
28
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
36
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
37
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 TPGS1  
Proximity Label-MS Homo sapiens
4 CEP120  
Two-hybrid Homo sapiens
5 HDAC2 3066
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
6 BCKDK 10295
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
7 MBLAC2 153364
Affinity Capture-MS Homo sapiens
8 STAT5B 6777
Co-localization Homo sapiens
9 PRKCD 5580
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
10 ATG5 9474
Proximity Label-MS Homo sapiens
11 GADD45A  
Affinity Capture-Western Homo sapiens
12 RPA2 6118
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
13 NUP62 23636
Proximity Label-MS Homo sapiens
14 MORC4  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
15 RRAD 6236
Reconstituted Complex Homo sapiens
16 TMEM206 55248
Affinity Capture-MS Homo sapiens
17 ANKRD26P1  
Affinity Capture-MS Homo sapiens
18 SPSB4  
Affinity Capture-MS Homo sapiens
19 C9orf78 51759
Affinity Capture-MS Homo sapiens
20 TRIM59  
Affinity Capture-Western Homo sapiens
21 POM121  
Two-hybrid Homo sapiens
22 SYNE2 23224
Affinity Capture-MS Homo sapiens
23 VHL  
Affinity Capture-Western Homo sapiens
24 IL22RA2  
Negative Genetic Homo sapiens
25 RET 5979
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
26 PTPN1 5770
Biochemical Activity Homo sapiens
27 COPA 1314
Proximity Label-MS Homo sapiens
28 ASXL1  
Two-hybrid Homo sapiens
29 KIF27  
Affinity Capture-MS Homo sapiens
30 MYOD1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 HDAC1 3065
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 APEX1 328
Affinity Capture-Western Homo sapiens
33 NFKB1 4790
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
34 LMO2  
Two-hybrid Homo sapiens
35 IL6ST 3572
Affinity Capture-Western Homo sapiens
36 HDAC3 8841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
38 PGK1 5230
Co-localization Homo sapiens
39 ZFHX3  
Affinity Capture-Western Homo sapiens
40 LUC7L2 51631
Co-fractionation Homo sapiens
41 COPE 11316
Proximity Label-MS Homo sapiens
42 FES 2242
Affinity Capture-Western Homo sapiens
43 COPS5 10987
Affinity Capture-Western Homo sapiens
44 FBXW7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
45 IMPDH2 3615
Two-hybrid Homo sapiens
46 SRC 6714
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
47 STAT3 6774
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
48 TCEAL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KHDRBS1 10657
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 BHLHE40  
Affinity Capture-Western Homo sapiens
51 CAPN1 823
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
52 CA9 768
Co-localization Homo sapiens
53 HIVEP1 3096
Two-hybrid Homo sapiens
54 RPS9 6203
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
55 GSDMB  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
56 ALK 238
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
57 ETNK2  
Affinity Capture-MS Homo sapiens
58 SRI 6717
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
59 BRD4 23476
Affinity Capture-MS Homo sapiens
60 PHF11 51131
Affinity Capture-MS Homo sapiens
61 SYK 6850
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 FAM101B  
Proximity Label-MS Homo sapiens
63 PRTN3 5657
Affinity Capture-MS Homo sapiens
64 SNX27 81609
Affinity Capture-MS Homo sapiens
65 SIAH2 6478
Two-hybrid Homo sapiens
66 RAD50 10111
Proximity Label-MS Homo sapiens
67 ERBB2 2064
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
68 FGFR1 2260
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
69 C18orf21  
Affinity Capture-MS Homo sapiens
70 NIF3L1 60491
Two-hybrid Homo sapiens
71 HAUS4  
Proximity Label-MS Homo sapiens
72 ZFPM2  
Two-hybrid Homo sapiens
73 NCOA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
74 HOXC11  
Two-hybrid Homo sapiens
75 USP22 23326
Affinity Capture-Western Homo sapiens
76 GTF2I 2969
Reconstituted Complex Homo sapiens
77 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RB1 5925
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
79 TSHR 7253
Affinity Capture-Western Homo sapiens
80 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
81 SEMA4C 54910
Affinity Capture-MS Homo sapiens
82 HNF1A  
Affinity Capture-Western Homo sapiens
83 ATP2A2 488
Proximity Label-MS Homo sapiens
84 FOXC1  
Affinity Capture-MS Homo sapiens
85 SULT2A1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
86 IRAK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
87 DLK2  
Affinity Capture-MS Homo sapiens
88 CDKN1A  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
89 PARK2  
Affinity Capture-MS Homo sapiens
90 IGF1R 3480
Co-localization Homo sapiens
91 RPS6KA3 6197
Biochemical Activity Homo sapiens
92 TAB3 257397
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
93 HIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
94 SOCS7  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
95 HSP90B1 7184
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
96 IL6R  
Affinity Capture-Western Homo sapiens
97 STMN1 3925
Affinity Capture-Western Homo sapiens
98 MBNL1 4154
Affinity Capture-MS Homo sapiens
99 RNF115  
Affinity Capture-MS Homo sapiens
100 COPB1 1315
Proximity Label-MS Homo sapiens
101 SRRT 51593
Two-hybrid Homo sapiens
102 HIF1AN 55662
Affinity Capture-MS Homo sapiens
103 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
104 COMP 1311
Affinity Capture-MS Homo sapiens
105 CSF2RB  
Affinity Capture-Western Homo sapiens
106 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
107 RB1CC1 9821
Affinity Capture-MS Homo sapiens
108 MAP3K13 9175
Two-hybrid Homo sapiens
109 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 IL1RAP 3556
Affinity Capture-Western Homo sapiens
111 TBC1D15 64786
Co-fractionation Homo sapiens
112 CCR5 1234
Affinity Capture-Western Homo sapiens
113 NXPH2  
Affinity Capture-MS Homo sapiens
114 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 TRIP10 9322
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
117 SSUH2  
Affinity Capture-MS Homo sapiens
118 BICD2 23299
Proximity Label-MS Homo sapiens
119 SCAF11  
Two-hybrid Homo sapiens
120 CHMP4B 128866
Affinity Capture-MS Homo sapiens
121 PTPN11 5781
Affinity Capture-Western Homo sapiens
122 HECTD1 25831
Affinity Capture-MS Homo sapiens
123 CTR9 9646
Affinity Capture-Western Homo sapiens
124 BMX  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
125 NFKB2 4791
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
126 MAPK8 5599
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
127 TMUB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 SETD7 80854
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
129 DAXX  
Affinity Capture-Western Homo sapiens
130 TIRAP  
Affinity Capture-MS Homo sapiens
131 ARFGAP1 55738
Proximity Label-MS Homo sapiens
132 RPS6KA1 6195
Biochemical Activity Homo sapiens
133 RPL11 6135
Two-hybrid Homo sapiens
134 PHLPP1  
Proximity Label-MS Homo sapiens
135 ECH1 1891
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
136 TRIM45  
Affinity Capture-Western Homo sapiens
137 NTRK1 4914
Affinity Capture-MS Homo sapiens
138 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
139 TRPV5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 NR4A1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
141 PIGT 51604
Affinity Capture-MS Homo sapiens
142 AGPAT1 10554
Affinity Capture-MS Homo sapiens
143 MSH2 4436
Co-fractionation Homo sapiens
144 NDUFA13 51079
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
145 PLA2G4A 5321
Affinity Capture-MS Homo sapiens
146 NFYC 4802
Co-fractionation Homo sapiens
147 GYPA  
Affinity Capture-MS Homo sapiens
148 ERBB2IP 55914
Two-hybrid Homo sapiens
149 SMAD1 4086
Affinity Capture-Western Homo sapiens
150 PDGFRA 5156
Co-localization Homo sapiens
151 IL22RA1 58985
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
152 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
153 CUL3 8452
Affinity Capture-MS Homo sapiens
154 NR3C1 2908
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
155 PDIA3 2923
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
156 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
157 BCL3  
Affinity Capture-Western Homo sapiens
158 PIAS3  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
159 METTL21B  
Affinity Capture-MS Homo sapiens
160 LRRC32 2615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
162 ELP2 55250
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
163 TBCD 6904
Co-fractionation Homo sapiens
164 VEGFA 7422
Co-localization Homo sapiens
165 ARFIP1 27236
Co-fractionation Homo sapiens
166 NXF1 10482
Affinity Capture-RNA Homo sapiens
167 MAGEC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
168 BLK 640
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
169 JUN 3725
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
170 GLUD1 2746
Affinity Capture-MS Homo sapiens
171 FGFR2 2263
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
172 RELB  
Co-localization Homo sapiens
173 TRIM32 22954
Affinity Capture-Western Homo sapiens
174 STAT1 6772
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
175 PTK2 5747
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
176 IFNAR1  
Affinity Capture-Western Homo sapiens
177 RPA3 6119
Proximity Label-MS Homo sapiens
178 JAK1 3716
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
179 GNB2 2783
Affinity Capture-Western Homo sapiens
180 GPR45  
Affinity Capture-MS Homo sapiens
181 AZU1 566
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 MTOR 2475
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
183 SPRY1 10252
Two-hybrid Homo sapiens
184 RUNX2  
Affinity Capture-Western Homo sapiens
185 SLC25A36  
Affinity Capture-MS Homo sapiens
186 SARAF  
Affinity Capture-MS Homo sapiens
187 KAT5  
Affinity Capture-Western Homo sapiens
188 MET 4233
Affinity Capture-Western Homo sapiens
189 COPB2 9276
Proximity Label-MS Homo sapiens
190 CORO1A 11151
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
191 BICD1 636
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
192 IL2RB  
Reconstituted Complex Homo sapiens
193 PVR 5817
Affinity Capture-MS Homo sapiens
194 STAT6 6778
Two-hybrid Homo sapiens
195 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
196 AMBP 259
Two-hybrid Homo sapiens
197 PML 5371
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
198 NFYA 4800
Co-fractionation Homo sapiens
199 CCND1 595
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
200 HLA-A 3105
Two-hybrid Homo sapiens
201 FHL2 2274
Two-hybrid Homo sapiens
202 STX17 55014
Affinity Capture-MS Homo sapiens
203 SH3KBP1 30011
Proximity Label-MS Homo sapiens
204 ARFIP2 23647
Two-hybrid Homo sapiens
205 GNL3 26354
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
206 OR2A4 79541
Affinity Capture-MS Homo sapiens
207 HIF1A 3091
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
208 LARS 51520
Proximity Label-MS Homo sapiens
209 LRRC49  
Proximity Label-MS Homo sapiens
210 RELA 5970
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
211 FGR 2268
Two-hybrid Homo sapiens
212 EIF3F 8665
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
213 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
214 PUS7 54517
Co-fractionation Homo sapiens
215 PCBD2 84105
Two-hybrid Homo sapiens
216 BANF1 8815
Affinity Capture-MS Homo sapiens
217 KAT2A  
Affinity Capture-Western Homo sapiens
218 SUPT20H 55578
Two-hybrid Homo sapiens
219 TP53 7157
Affinity Capture-MS Homo sapiens
220 SIN3A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
221 NFKBIZ  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
222 SRP72 6731
Proximity Label-MS Homo sapiens
223 C3AR1  
Affinity Capture-MS Homo sapiens
224 NMI  
Reconstituted Complex Homo sapiens
225 RFWD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
226 PELP1 27043
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
227 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
228 MRPS31  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
229 RP2 6102
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
230 SS18L1  
Two-hybrid Homo sapiens
231 KIAA1429 25962
Affinity Capture-MS Homo sapiens
232 CCR1  
Affinity Capture-MS Homo sapiens
233 HNRNPM 4670
Two-hybrid Homo sapiens
234 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
235 C1orf35  
Affinity Capture-MS Homo sapiens
236 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
237 PTPN2 5771
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
238 CREBBP  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
239 CAPNS1 826
Two-hybrid Homo sapiens
240 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
241 SHMT2 6472
Affinity Capture-RNA Homo sapiens
242 SSBP2  
Affinity Capture-MS Homo sapiens
243 CREB1  
Affinity Capture-Western Homo sapiens
244 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
245 RGPD1  
Proximity Label-MS Homo sapiens
246 OGDHL  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
247 MAPK1 5594
Affinity Capture-Western Homo sapiens
248 POU2F1 5451
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
249 ESR1  
Affinity Capture-Western Homo sapiens
250 IDE 3416
Co-fractionation Homo sapiens
251 EPHA5 2044
Affinity Capture-Western Homo sapiens
252 WWP2 11060
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
253 ADRB2  
PCA Homo sapiens
254 KDM1A 23028
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
255 NFYB  
Co-fractionation Homo sapiens
256 MOV10 4343
Affinity Capture-RNA Homo sapiens
257 PSMG3 84262
Co-fractionation Homo sapiens
258 RXRA 6256
Co-fractionation Homo sapiens
259 CDK9 1025
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
260 PINK1  
Affinity Capture-MS Homo sapiens
261 LAMB2 3913
Two-hybrid Homo sapiens
262 SSSCA1 10534
Two-hybrid Homo sapiens
263 CUL4A 8451
Affinity Capture-MS Homo sapiens
264 MEG3  
Affinity Capture-RNA Homo sapiens
265 RPRD1B 58490
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
266 CEBPB  
Affinity Capture-Western Homo sapiens
267 GHR  
Reconstituted Complex Homo sapiens
268 CACNG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
269 CD44 960
Affinity Capture-Western Homo sapiens
270 AR 367
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
271 PGR  
Affinity Capture-Western Homo sapiens
272 RAC1 5879
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
273 MYC  
Negative Genetic Homo sapiens
274 VASN 114990
Affinity Capture-MS Homo sapiens
275 IVNS1ABP  
Co-fractionation Homo sapiens
276 DNMT1 1786
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
277 JAK2 3717
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
278 UBE2I 7329
Proximity Label-MS Homo sapiens
279 SIK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
280 PDGFRB 5159
Co-localization Homo sapiens
281 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which STAT3 is involved
PathwayEvidenceSource
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Apoptosis TAS Reactome
Association of TriC/CCT with target proteins during biosynthesis IEA Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members TAS Reactome
Cellular response to chemical stress IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress TAS Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence TAS Reactome
Chaperonin-mediated protein folding IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytoprotection by HMOX1 IEA Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signal transduction TAS Reactome
FGFR1 mutant receptor activation TAS Reactome
Growth hormone receptor signaling IEA Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling IEA Reactome
Interferon Signaling TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-10 signaling TAS Reactome
Interleukin-12 family signaling TAS Reactome
Interleukin-12 family signaling IEA Reactome
Interleukin-15 signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-20 family signaling TAS Reactome
Interleukin-21 signaling TAS Reactome
Interleukin-23 signaling TAS Reactome
Interleukin-23 signaling IEA Reactome
Interleukin-27 signaling TAS Reactome
Interleukin-35 Signalling TAS Reactome
Interleukin-37 signaling TAS Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
Interleukin-6 family signaling TAS Reactome
Interleukin-6 signaling TAS Reactome
Interleukin-7 signaling IEA Reactome
Interleukin-7 signaling TAS Reactome
Interleukin-9 signaling TAS Reactome
Intrinsic Pathway for Apoptosis TAS Reactome
MET activates STAT3 IEA Reactome
MET activates STAT3 TAS Reactome
Metabolism of proteins IEA Reactome
Nuclear events stimulated by ALK signaling in cancer TAS Reactome
PKR-mediated signaling TAS Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation TAS Reactome
Programmed Cell Death TAS Reactome
Protein folding IEA Reactome
PTK6 Activates STAT3 TAS Reactome
PTK6 Activates STAT3 IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by cytosolic FGFR1 fusion mutants TAS Reactome
Signaling by FGFR in disease TAS Reactome
Signaling by FGFR1 in disease TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by Leptin IEA Reactome
Signaling by MET IEA Reactome
Signaling by MET TAS Reactome
Signaling by Non-Receptor Tyrosine Kinases TAS Reactome
Signaling by Non-Receptor Tyrosine Kinases IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by PDGF TAS Reactome
Signaling by PDGFR in disease TAS Reactome
Signaling by PDGFRA extracellular domain mutants TAS Reactome
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by PTK6 TAS Reactome
Signaling by PTK6 IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signalling to STAT3 IEA Reactome
STAT3 nuclear events downstream of ALK signaling TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Transcriptional regulation of pluripotent stem cells TAS Reactome





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