Gene description for HIST1H2AE
Gene name histone cluster 1, H2ae
Gene symbol HIST1H2AE
Other names/aliases H2A.1
H2A.2
H2A/a
H2AFA
Species Homo sapiens
 Database cross references - HIST1H2AE
ExoCarta ExoCarta_3012
Vesiclepedia VP_3012
Entrez Gene 3012
HGNC 4724
MIM 602786
UniProt P04908  
 HIST1H2AE identified in sEVs derived from the following tissue/cell type
Bladder cancer cells 20224111    
Colorectal cancer cells 19837982    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Endothelial cells 26027894    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Mesenchymal stem cells Unpublished / Not applicable
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Saliva 19199708    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for HIST1H2AE
Molecular Function
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IBA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    chromatin organization GO:0006325 NAS
    negative regulation of cell population proliferation GO:0008285 IMP
    heterochromatin formation GO:0031507 IBA
    protein localization to CENP-A containing chromatin GO:0061644 NAS
Subcellular Localization
    nucleosome GO:0000786 IBA
    nucleosome GO:0000786 IPI
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    CENP-A containing nucleosome GO:0043505 IPI
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST1H2AE in sEVs
1
Experiment ID 76
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
7
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
8
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
9
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
10
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
11
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
12
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
13
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
16
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
17
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
18
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
19
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
20
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
21
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
22
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
23
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HIST1H2AE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HLTF  
Affinity Capture-MS Homo sapiens
2 XPC  
Affinity Capture-MS Homo sapiens
3 RPL26L1 51121
Affinity Capture-MS Homo sapiens
4 MRPL48  
Affinity Capture-MS Homo sapiens
5 HMCES  
Affinity Capture-MS Homo sapiens
6 MRPL17  
Affinity Capture-MS Homo sapiens
7 RPS17 6218
Affinity Capture-MS Homo sapiens
8 ANAPC5 51433
Affinity Capture-MS Homo sapiens
9 EPB41L5 57669
Affinity Capture-MS Homo sapiens
10 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
11 RPS19 6223
Affinity Capture-MS Homo sapiens
12 MRPL10 124995
Affinity Capture-MS Homo sapiens
13 HNRNPD 3184
Affinity Capture-MS Homo sapiens
14 CAND1 55832
Affinity Capture-MS Homo sapiens
15 PARK7 11315
Affinity Capture-MS Homo sapiens
16 MSH3 4437
Affinity Capture-MS Homo sapiens
17 UTP3 57050
Affinity Capture-MS Homo sapiens
18 RPS3 6188
Affinity Capture-MS Homo sapiens
19 USP36  
Affinity Capture-MS Homo sapiens
20 COPS5 10987
Affinity Capture-MS Homo sapiens
21 XRCC1 7515
Affinity Capture-MS Homo sapiens
22 WDR76  
Affinity Capture-MS Homo sapiens
23 MCM2 4171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MPHOSPH10 10199
Affinity Capture-MS Homo sapiens
25 PLK4  
Affinity Capture-MS Homo sapiens
26 IMPDH2 3615
Proximity Label-MS Homo sapiens
27 NPM1 4869
Proximity Label-MS Homo sapiens
28 PHF14 9678
Affinity Capture-MS Homo sapiens
29 H2AFY2 55506
Affinity Capture-MS Homo sapiens
30 KRI1  
Affinity Capture-MS Homo sapiens
31 MCM6 4175
Affinity Capture-MS Homo sapiens
32 MRPL57  
Affinity Capture-MS Homo sapiens
33 SPTY2D1  
Affinity Capture-MS Homo sapiens
34 GINS4  
Affinity Capture-MS Homo sapiens
35 ITGA4 3676
Affinity Capture-MS Homo sapiens
36 DDX18 8886
Affinity Capture-MS Homo sapiens
37 NAP1L4 4676
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
38 FAM111A 63901
Affinity Capture-MS Homo sapiens
39 CUL1 8454
Affinity Capture-MS Homo sapiens
40 SOD1 6647
Affinity Capture-MS Homo sapiens
41 HIST2H4A 8370
Affinity Capture-MS Homo sapiens
42 CTCF  
Affinity Capture-MS Homo sapiens
43 CCDC86  
Affinity Capture-MS Homo sapiens
44 ZCRB1  
Affinity Capture-MS Homo sapiens
45 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
46 PPM1B 5495
Affinity Capture-MS Homo sapiens
47 H2AFZ 3015
Affinity Capture-MS Homo sapiens
48 TRIM41 90933
Affinity Capture-MS Homo sapiens
49 DLD 1738
Affinity Capture-MS Homo sapiens
50 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
51 COX15 1355
Affinity Capture-MS Homo sapiens
52 CDC23 8697
Affinity Capture-MS Homo sapiens
53 CUL4B 8450
Affinity Capture-MS Homo sapiens
54 RPS10 6204
Affinity Capture-MS Homo sapiens
55 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
56 LARP7 51574
Affinity Capture-MS Homo sapiens
57 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
58 POLR3F  
Affinity Capture-MS Homo sapiens
59 CFDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 RPL31 6160
Affinity Capture-MS Homo sapiens
61 RAD18  
Affinity Capture-MS Homo sapiens
62 GINS1  
Affinity Capture-MS Homo sapiens
63 DHFRL1  
Proximity Label-MS Homo sapiens
64 ANAPC4 29945
Affinity Capture-MS Homo sapiens
65 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
66 PELP1 27043
Affinity Capture-MS Homo sapiens
67 H2AFY 9555
Affinity Capture-MS Homo sapiens
68 PPM1G 5496
Affinity Capture-MS Homo sapiens
69 DNM1L 10059
Affinity Capture-MS Homo sapiens
70 PRKACB 5567
Affinity Capture-MS Homo sapiens
71 NFX1  
Affinity Capture-MS Homo sapiens
72 PURB 5814
Affinity Capture-MS Homo sapiens
73 IPO9 55705
Affinity Capture-MS Homo sapiens
74 TONSL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 MIER3 166968
Affinity Capture-MS Homo sapiens
76 MIER1  
Affinity Capture-MS Homo sapiens
77 HIST1H3F 8968
Affinity Capture-MS Homo sapiens
78 SPATS2L 26010
Affinity Capture-MS Homo sapiens
79 DAP3 7818
Affinity Capture-MS Homo sapiens
80 DHX36 170506
Affinity Capture-MS Homo sapiens
81 SDHA 6389
Affinity Capture-MS Homo sapiens
82 YTHDC2 64848
Affinity Capture-MS Homo sapiens
83 EPAS1  
Affinity Capture-MS Homo sapiens
84 RLIM 51132
Affinity Capture-MS Homo sapiens
85 MRPL27 51264
Affinity Capture-MS Homo sapiens
86 MRPL16  
Affinity Capture-MS Homo sapiens
87 HYPK 25764
Affinity Capture-MS Homo sapiens
88 RPL3 6122
Affinity Capture-MS Homo sapiens
89 ZC3H8  
Affinity Capture-MS Homo sapiens
90 HSD17B10 3028
Affinity Capture-MS Homo sapiens
91 GADD45GIP1  
Affinity Capture-MS Homo sapiens
92 MCM4 4173
Affinity Capture-MS Homo sapiens
93 NAP1L1 4673
Affinity Capture-MS Homo sapiens
94 SUZ12  
Affinity Capture-MS Homo sapiens
95 CLSPN  
Affinity Capture-MS Homo sapiens
96 NXF1 10482
Affinity Capture-RNA Homo sapiens
97 GINS3  
Affinity Capture-MS Homo sapiens
98 ZNF512  
Affinity Capture-MS Homo sapiens
99 CDYL 9425
Affinity Capture-MS Homo sapiens
100 SS18L2  
Affinity Capture-MS Homo sapiens
101 LTV1  
Affinity Capture-MS Homo sapiens
102 DLST 1743
Affinity Capture-MS Homo sapiens
103 PRDM13 59336
Affinity Capture-MS Homo sapiens
104 ZFP91 80829
Affinity Capture-MS Homo sapiens
105 MMS22L  
Affinity Capture-MS Homo sapiens
106 CDY2A  
Affinity Capture-MS Homo sapiens
107 VDAC1 7416
Affinity Capture-MS Homo sapiens
108 NOP16 51491
Affinity Capture-MS Homo sapiens
109 CETN2 1069
Affinity Capture-MS Homo sapiens
110 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
111 RPL26 6154
Affinity Capture-MS Homo sapiens
112 APLF  
Affinity Capture-MS Homo sapiens
113 SUPT16H 11198
Affinity Capture-MS Homo sapiens
114 MRPL18 29074
Affinity Capture-MS Homo sapiens
115 HUWE1 10075
Affinity Capture-MS Homo sapiens
116 RPS16 6217
Affinity Capture-MS Homo sapiens
117 U2SURP 23350
Affinity Capture-MS Homo sapiens
118 YBX1 4904
Affinity Capture-MS Homo sapiens
119 DDX50 79009
Affinity Capture-MS Homo sapiens
120 SURF6  
Affinity Capture-MS Homo sapiens
121 BCAS2 10286
Affinity Capture-MS Homo sapiens
122 PARP1 142
Affinity Capture-MS Homo sapiens
123 LIG3 3980
Affinity Capture-MS Homo sapiens
124 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
125 CUL5 8065
Affinity Capture-MS Homo sapiens
126 PDHA1 5160
Affinity Capture-MS Homo sapiens
127 KNOP1 400506
Affinity Capture-MS Homo sapiens
128 HIST1H2BN 8341
Two-hybrid Homo sapiens
129 RPS15 6209
Affinity Capture-MS Homo sapiens
130 ANAPC1 64682
Affinity Capture-MS Homo sapiens
131 GON4L  
Affinity Capture-MS Homo sapiens
132 LUC7L 55692
Affinity Capture-MS Homo sapiens
133 SHMT2 6472
Affinity Capture-RNA Homo sapiens
134 TIMELESS  
Affinity Capture-MS Homo sapiens
135 PARP2  
Affinity Capture-MS Homo sapiens
136 KRR1 11103
Affinity Capture-MS Homo sapiens
137 COQ2  
Affinity Capture-MS Homo sapiens
138 KDM1A 23028
Proximity Label-MS Homo sapiens
139 RPS24 6229
Affinity Capture-MS Homo sapiens
140 MOV10 4343
Affinity Capture-RNA Homo sapiens
141 EZH2  
Affinity Capture-MS Homo sapiens
142 YBX3 8531
Affinity Capture-MS Homo sapiens
143 NEDD8 4738
Affinity Capture-MS Homo sapiens
144 XRCC6 2547
Affinity Capture-MS Homo sapiens
145 HIRA  
Affinity Capture-MS Homo sapiens
146 EID1  
Reconstituted Complex Homo sapiens
147 RPL36AL 6166
Affinity Capture-MS Homo sapiens
148 RSF1  
Affinity Capture-MS Homo sapiens
149 CKAP4 10970
Proximity Label-MS Homo sapiens
150 CUEDC1 404093
Affinity Capture-MS Homo sapiens
151 SSRP1 6749
Affinity Capture-MS Homo sapiens
152 TEX10 54881
Affinity Capture-MS Homo sapiens
153 C16orf87 388272
Affinity Capture-MS Homo sapiens
154 PRKRIR  
Affinity Capture-MS Homo sapiens
155 CUL4A 8451
Affinity Capture-MS Homo sapiens
156 TIPIN  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HIST1H2AE is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones IEA Reactome
HATs acetylate histones TAS Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Metalloprotease DUBs TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RMTs methylate histone arginines TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
UCH proteinases TAS Reactome
Viral Infection Pathways TAS Reactome





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