Gene description for ZPR1
Gene name ZPR1 zinc finger
Gene symbol ZPR1
Other names/aliases ZNF259
Species Homo sapiens
 Database cross references - ZPR1
ExoCarta ExoCarta_8882
Vesiclepedia VP_8882
Entrez Gene 8882
HGNC 13051
MIM 603901
UniProt O75312  
 ZPR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZPR1
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    receptor tyrosine kinase binding GO:0030971 IEA
    translation initiation factor binding GO:0031369 IBA
    translation initiation factor binding GO:0031369 IPI
    protein folding chaperone GO:0044183 ISS
Biological Process
    microtubule cytoskeleton organization GO:0000226 ISS
    inner cell mass cell proliferation GO:0001833 IEA
    trophectodermal cell proliferation GO:0001834 ISS
    DNA replication GO:0006260 IMP
    mRNA processing GO:0006397 IEA
    protein folding GO:0006457 ISS
    signal transduction GO:0007165 TAS
    RNA splicing GO:0008380 IEA
    positive regulation of gene expression GO:0010628 IBA
    positive regulation of gene expression GO:0010628 IMP
    spinal cord development GO:0021510 ISS
    Cajal body organization GO:0030576 IBA
    Cajal body organization GO:0030576 ISS
    regulation of myelination GO:0031641 ISS
    positive regulation of RNA splicing GO:0033120 IMP
    DNA endoreduplication GO:0042023 ISS
    positive regulation of protein import into nucleus GO:0042307 IBA
    positive regulation of protein import into nucleus GO:0042307 IDA
    positive regulation of cell cycle GO:0045787 IMP
    positive regulation of growth GO:0045927 ISS
    axon development GO:0061564 IBA
    axon development GO:0061564 IMP
    axon development GO:0061564 ISS
    cellular response to epidermal growth factor stimulus GO:0071364 IDA
    apoptotic process involved in development GO:1902742 ISS
    pre-mRNA catabolic process GO:1990261 IMP
    negative regulation of motor neuron apoptotic process GO:2000672 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    Cajal body GO:0015030 IBA
    Cajal body GO:0015030 IDA
    axon GO:0030424 IBA
    axon GO:0030424 ISS
    growth cone GO:0030426 ISS
    neuronal cell body GO:0043025 ISS
    perikaryon GO:0043204 ISS
    perinuclear region of cytoplasm GO:0048471 IEA
    Gemini of coiled bodies GO:0097504 IDA
 Experiment description of studies that identified ZPR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZPR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 P3H1 64175
Co-fractionation Homo sapiens
2 YWHAE 7531
Co-fractionation Homo sapiens
3 ATP6V1B2 526
Co-fractionation Homo sapiens
4 ACTR2 10097
Co-fractionation Homo sapiens
5 SURF2  
Co-fractionation Homo sapiens
6 ALAD 210
Co-fractionation Homo sapiens
7 OGT 8473
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
8 RIT1 6016
Negative Genetic Homo sapiens
9 PSMA3 5684
Co-fractionation Homo sapiens
10 KLC2 64837
Co-fractionation Homo sapiens
11 UBQLN4 56893
Co-fractionation Homo sapiens
12 UBE2A  
Co-fractionation Homo sapiens
13 FKBP10 60681
Co-fractionation Homo sapiens
14 RPRD1B 58490
Co-fractionation Homo sapiens
15 LPP 4026
Co-fractionation Homo sapiens
16 UFC1 51506
Co-fractionation Homo sapiens
17 TES 26136
Co-fractionation Homo sapiens
18 AHCYL1 10768
Co-fractionation Homo sapiens
19 FAS 355
Proximity Label-MS Homo sapiens
20 SNUPN 10073
Reconstituted Complex Homo sapiens
21 SRXN1 140809
Co-fractionation Homo sapiens
22 UBXN7 26043
Co-fractionation Homo sapiens
23 SULT1A1 6817
Co-fractionation Homo sapiens
24 ARPC4 10093
Co-fractionation Homo sapiens
25 UBE2L3 7332
Co-fractionation Homo sapiens
26 SZRD1 26099
Co-fractionation Homo sapiens
27 PAICS 10606
Co-fractionation Homo sapiens
28 IKBKG 8517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 HYPK 25764
Co-fractionation Homo sapiens
30 TJP1 7082
Co-fractionation Homo sapiens
31 UBE4B 10277
Co-fractionation Homo sapiens
32 RPA3 6119
Proximity Label-MS Homo sapiens
33 AGFG1 3267
Co-fractionation Homo sapiens
34 THOC7 80145
Co-fractionation Homo sapiens
35 OSGEP 55644
Co-fractionation Homo sapiens
36 THOC5 8563
Co-fractionation Homo sapiens
37 ETF1 2107
Co-fractionation Homo sapiens
38 FKBP1A 2280
Co-fractionation Homo sapiens
39 MPP3  
Two-hybrid Homo sapiens
40 C17orf53  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TXNDC9 10190
Co-fractionation Homo sapiens
42 ATP6V1F 9296
Co-fractionation Homo sapiens
43 TOM1L1 10040
Co-fractionation Homo sapiens
44 CDK5RAP2 55755
Two-hybrid Homo sapiens
45 NUDCD2 134492
Co-fractionation Homo sapiens
46 VPS26A 9559
Co-fractionation Homo sapiens
47 UBE2D2 7322
Co-fractionation Homo sapiens
48 C5orf22  
Co-fractionation Homo sapiens
49 HSPBP1 23640
Co-fractionation Homo sapiens
50 PHPT1 29085
Co-fractionation Homo sapiens
51 ABHD5 51099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 YAP1 10413
Co-fractionation Homo sapiens
53 CDC123 8872
Co-fractionation Homo sapiens
54 ZYX 7791
Co-fractionation Homo sapiens
55 NTRK1 4914
Affinity Capture-MS Homo sapiens
56 HSF1  
Co-fractionation Homo sapiens
57 EGFR 1956
Negative Genetic Homo sapiens
58 ACTR3 10096
Co-fractionation Homo sapiens
59 SSSCA1 10534
Co-fractionation Homo sapiens
60 HNRNPF 3185
Co-fractionation Homo sapiens
61 SERBP1 26135
Affinity Capture-MS Homo sapiens
62 UBL7  
Co-fractionation Homo sapiens
63 UBA2 10054
Co-fractionation Homo sapiens
64 PPP1R7 5510
Co-fractionation Homo sapiens
65 UHRF1 29128
Co-fractionation Homo sapiens
66 KRAS 3845
Negative Genetic Homo sapiens
67 ZBTB42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 NEU4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 BAG1 573
Co-fractionation Homo sapiens
70 VPS4B 9525
Co-fractionation Homo sapiens
71 STAM 8027
Co-fractionation Homo sapiens
72 KIF4A 24137
Co-fractionation Homo sapiens
73 UBE2V2 7336
Co-fractionation Homo sapiens
74 UBXN1 51035
Co-fractionation Homo sapiens
75 UFM1 51569
Co-fractionation Homo sapiens
76 PPME1 51400
Co-fractionation Homo sapiens
77 ARIH1 25820
Co-fractionation Homo sapiens
78 UBE2D1 7321
Co-fractionation Homo sapiens
79 EEF1A1 1915
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which ZPR1 is involved
No pathways found





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